Molecular hydrogen water overview-definiton, benefits, research , studies ,safety

Molecular hydrogen water overview-definiton, benefits, research , studies  ,safety

molecular hydrogen water might sound new but it is not .

What is molecular hydrogen rich water ?molecular hydrogen  water or molecular hydrogen -rich water is water enriched or infused with dissolved  molecular hydrogen gas (molecular hydrogen  H2 NOT the H2 linked to O), also known as molecular hydrogen. 2 This means that hydrogen molecules or nano bubbles of molecular hydrogen are dissolved in the water, but do not actually bond with any of the H20 water molecules . another example are carbonated drinks  are enriched with CO2 (carbon dioxide gas) which gives these drinks their fizzy characteristic. 

So we have a gas made of 2 molecules of hydrogen in the water. Please note that alkaline ionize water also has more or less molecular hydrogen  H2 gas in it so Alkaline Ionized Water or Electrolysis Reduced Water is also Molecular Hydrogen Water

What is hydrogen gas?

Hydrogen gas is made up of two hydrogen atoms that are covalently bonded (2 atoms of hydrogen that share common electrons). This gas has a neutral charge and is the smallest and lightest gas in the universe. 6 These qualities make hydrogen gas extremely unique because it means molecular hydrogen  H2 can get anywhere it wants to in your body, including passing the blood-brain barrier, and into subcellular compartments such as the mitochondria of your cells. Molecular hydrogen is also known as a therapeutic medical gas with amazing medical potential in the scientific literature. 7

Is molecular hydrogen-rich water beneficial?

OF COURSE!!! Molecular hydrogen(water) has been demonstrated to be therapeutic in more than 600 scientific studies for more than 170 human disease models. 8 This means molecular hydrogen (water) has the therapeutic potential to help the vast majority of individuals today. Molecular hydrogen(water) has the potential to help the person dealing with seasonal allergies and to the person facing cancer. 9 Molecular hydrogen is one of the newest and simplest ways an individual can take preventative measures in their health.

Here are some examples of scientific studies refferring to molecular hydrogen) : In 1975, an impressive study demonstrated that hyperbaric molecular hydrogen therapy could be a possible treatment for cancer. In this study, the researchers showed that exposing mice with skin cancer (tumors) to 2.5 percent oxygen (O2) and 97.5 molecular hydrogen (H2) for two weeks produced a dramatic and significant regression of the mice tumors. Here is a quote from the study:

 “After a first 10-day period of exposure of the mice to the hydrogen-oxygen therapy it was found qualitatively (i) that the tumors had turned black, (ii) that some had dropped off, (iii) that some seemed to have shrunk at their base and to be in the process of being ‘pinched off,’ and (iv) that the mice appeared to suffer no deleterious consequences.” 5

In 2007 when a groundbreaking study demonstrated that molecular hydrogen is a selective antioxidant that neutralizes only the cytotoxic free radicals. The study was published in the prestigious Journal of Nature Medicine. 6 The study showed that molecular hydrogen neutralizes the hydroxyl radical (OH*), the most cytotoxic free radical in existence, one that the human body has no natural defenses against, and converts it into water.

Since 2007, medical research on molecular hydrogen has exploded proving this gas has remarkable medical potential.

Research studies and reviews about molecular hydrogen water

The evolution of molecular hydrogen (water): a noteworthy potential therapy with clinical significance

“Hydrogen has marked therapeutic potential to help with the top 8 fatality-causing diseases listed by the CDC.” 7

Molecular hydrogen: a therapeutic antioxidant and beyond

“Overall, the impact of molecular hydrogen in medicine is extraordinary. The non-toxic and rapid intracellular diffusion features of this biological gas ensure the feasibility and readiness for its clinical translation.” 8

Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications

“Recent publications revealed that, in addition to the direct neutralization of highly reactive oxidants, molecular hydrogen  H2 indirectly reduces oxidative stress by regulating the expression of various genes. Moreover, by regulating gene expression, molecular hydrogen H2 functions as an anti-inflammatory, antiallergic, and antiapoptotic molecule, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under way. Since most drugs act on their specific targets,molecular hydrogen H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, molecular hydrogen  H2 has potential for clinical applications for many diseases.” 9

Understanding the basic effects

Molecular hydrogen is a selective antioxidant 10

Molecular hydrogen appears to be a selective antioxidant. Molecular hydrogen appears to also reduce a powerful oxidant, Peroxynitrite (ONOO-). This would mean that Molecular Hydrogen has the potential to protect our DNA/RNA and proteins from damage (oxidative stress). Importantly, it does this while not perturbing cellular homeostasis;molecular hydrogen H2 does not neutralize beneficial free radicals (NO, H2O2, etc) necessary for the body to function properly.

Molecular hydrogen is a Nrf2 activator 11

Molecular hydrogen appears to stimulate the production of endogenous antioxidants via the Nrf2 Pathway, meaning it up-regulates the body’s own antioxidant system. This results in the production of more protective enzymes (antioxidants) such as glutathione, catalase, and superoxide dismutase. These antioxidants are powerful and aid in the reduction of excessive ROS and oxidative-stress within the body, which have been linked to nearly all human diseases.11.5

Molecular hydrogen is a signaling molecule/gene regulator 12

Molecular hydrogen appears to be a novel signaling molecule that participates in gene expression, cell modulation, and protein regulation. This means molecular hydrogen  H2 can alter cellular signaling pathways resulting in benefits far beyond its antioxidant function. Research has demonstrated that molecular hydrogen can regulate inflammatory cytokines, hormones, proteins, and much more.  Because of these properties, molecular hydrogen has the potential to give anti-inflammatory, anti-allergic, anti-cell death effects.

This is a short list of the potential therapeutic benefits for the human body that have been associated with molecular hydrogen  H2 research:

  • Selective antioxidant 10
  • Anti-Inflammatory Effects 11
  • Smallest, most bioavailable molecule 12
  • Aids in Gene Expression and regulation of proteins 13
  • Anti-Allergic Effects 14
  • Anti-Cellular Death (anti-apoptotic) 15
  • Increases Endogenous Antioxidants 16
  • Anti-Diabetic Effects 17
  • Anti-Cancer Effects 18
  • Improve Cognitive Function 19
  • Protects DNA & RNA 20
  • Anti-Tumor Effect 21

Based on scientific studies/evidence, molecular hydrogen gas ( water )therapy has the potential to benefit:

Alzheimer’s 37, arthritis 38, rheumatoid arthritis 39, Type 1 diabetes 40, Type 2 diabetes 41, Parkinson’s 42, COPD 43, asthma 44, heart disease 45, kidney disease 46, stroke 47, cancer 48, tumors 49, ALS 50, dementia 51, psoriasis 52, dermatitis 53, IBS 54, hemorrhagic shock 55, Crohn’s 56, fatty liver disease 57, liver cirrhosis 58, pancreatitis 59, cardiac arrest 60, neuropathy 61, Multiple Sclerosis 62, Hepatitis B 63, atherosclerosis 64, cataracts 65, hypertension 66, gum disease 67, traumatic brain injury 68, sepsis 69, subarachnoid hemorrhage (aneurysms) 70, infant lung disease 71, metabolic syndrome 72, lymphoma 73, retinitis 74, painful bladder syndrome 75, osteosclerosis 76, osteoarthritis 77, osteoporosis 78, glaucoma 79, pulmonary hypertension 80, pulmonary fibrosis 81, autism 82, depression 83, bipolar disorder 84, anxiety 85, schizophrenia 86, inflammation 87, muscle fatigue 88, increased ATP production 89, soft tissue injuries 90, pain 91, wounds 92, burns 93, seasonal allergies 94, autoimmune disorders 95, insulin resistance 96, hearing loss 97, ulcers 98, radiation damage 99, sleep apnea 100to name just a few as there are studies on over 170 human disease models

Who can drink molecular hydrogen water?

One of the best parts about molecular hydrogen water is that it has been shown to have a tremendous safety profile. This has been demonstrated in a few ways:

  • Out of 600-plus scientific studies, molecular hydrogen  H2 has shown no cytotoxic effects or cytotoxic by-products in the human body. 22
  • We have a basal level of molecular hydrogen  H2 in our blood stream at all times, around 1~5 micromolar or less. 23
  • Humans can produce up to 10 liters of molecular hydrogen  H2 a day with a good diet containing fruits, vegetables, and fiber-rich foods. This is due to the production of molecular hydrogen  H2 by our gut flora (gut bacteria). 24
  • Another reason we know molecular hydrogen H2 is safe is because it has been used to ameliorate decompression sickness in deep sea diving since 1945. 25 The molecular hydrogen H2 concentration has been as high 98.87 percent molecular hydrogen  H2 and 1.26 percent of O2, at 19.1 atm with minimal to no adverse or cytotoxic effects. 26 The United States military also has been using molecular hydrogen H2 for deep sea diving since the 60s. 27 Molecular hydrogen has been demonstrated to be extremely safe for the human body. 28


This information tells us that molecular hydrogen-rich water is safe for consumption in all age groups, from children to adults, as a preventive beverage that has the potential to reduce oxidative stress and so much more. Everyone, including children, is exposed to oxidative stress, which has been linked to the pathogenesis of nearly all disease conditions, including cancer. 29 Consuming water infused with molecular hydrogen is exactly what our society needs to aid in the battle against degenerative diseases.

Please note that most studies and research with molecular hydrogen gas were performed using molecular hydrogen rich water


To learn more about molecular hydrogen or hydrogen water’s potential health benefits and to see supporting scientific research visit:

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