Alkaline Ionized Water/ Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis 

Alkaline Ionized Water/ Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis

Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis -evoked oxidative stress as indicated by lipid peroxidation, hemolysis, and overexpression of proinflammatory cytokines in hemodialysis patients:

We explored whether alkaline ionized water/electrolyte-reduced water (ERW) could palliate chronic hemodialysis HD-evoked erythrocyte impairment and anemia.(Chronic hemodialysis (HD) patients increase erythrocyte susceptibility to hemolysis and impair cell survival).

43 patients undergoing chronic hemodialysis were enrolled and received alkaline ionized water/electrolyte-reduced water ERW administration for 6 month. We evaluated oxidative stress in blood and plasma, erythrocyte methemoglobin (metHb)/ferricyanide reductase activity, plasma metHb, and proinflammatory cytokines in the chronic hemodialysis  patients without treatment (n=15) or with vitamin C (VC)- (n=15), vitamin E (VE)-coated dialyzer (n=15), or alkaline ionized water/electrolyte-reduced water ERW treatment (n=15) during an  hemodialysis HD course.

The patients showed marked increases (15-fold) in blood reactive oxygen species, mostly H(2)O(2), after  hemodialysis without any treatment.  hemodialysis  resulted in decreased plasma Vitamin C, total antioxidant status, and erythrocyte metHb/ferricyanide reductase activity and increased erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and plasma metHb.

Antioxidants treatment significantly palliated single  hemodialysis course-induced oxidative stress, plasma and RBC PCOOH, and plasma metHb levels, and preserved erythrocyte metHb /ferricyanide reductase activity in an order Vitamin C>Electrolyte Reduced Water>Vitamin E-coated dialyzer.

However, Electrolyte Reduced Water had no side effects of oxalate accumulation easily induced by Vitamin C.

Six-month Electrolyte Reduced Water treatment increased hematocrit and attenuated proinflammatory cytokines profile in the hemodialysis patients.

In conclusion, Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis-evoked oxidative stress, as indicated by lipid peroxidation, hemolysis, and overexpression of proinflammatory cytokines in hemodialysis patients.

PMID:16760903
DOI:10.1038/sj.ki.5001576
 2006 Jul;70(2):391-8. Epub 2006 Jun 7.

Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.

Author information

1
Department of Family Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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