antioxidant foods VS molecular hydrogen

 Plant-based antioxidants compared to molecular hydrogen antioxidant


Plant-based antioxidants compared to molecular hydrogen antioxidant


Due to the fact that molecular hydrogen and plant based antioxidants are different things yet they are both antioxidants we could start by saing molecular hydrogen and plant based antioxidants are complementary – dont ever think that consuming an amount of molecular hydrogen is equivalent to consuming a certain amount of antioxidants from natural foods like fruits and vegetables and nuts and other antioxidant rich foods.


Antioxidants in foods are essential nutrients,1 like vitamin C.2 This antioxidant does more than just neutralize free radicals3, but also plays an important role in areas like collagen synthesis4  , cell respiration/ oxygenation(aka respiratory vitamin), fighting viruses ad other important roles .

an example of oxidation neutralization : compare Vitamin’s C antioxidative power with the antioxidative power of molecular hydrogen ?

Drinking 1 liter of hydrogen-rich water at a concentration of 1.4 ppm(you will need a great  machine to do that like AlkaViva Vesta H2 water – ionizer or a Ionpia H2 molecular hydrogen water generator), would provide you about the same number of “antioxidant molecules” (hydrogen gas), as ingesting 100 mg of “antioxidant molecules” (vitamin C).

Based on stoichiometry, one molecule of vitamin C can theoretically neutralize two free radicals, which is the same for molecular hydrogen.5

However, some of the used vitamin C molecules can be rejuvenated by the body and can be used again6, which is not the case with molecular hydrogen wich is a gaz. On the other hand, molecular hydrogen can upregulate powerful antioxidant enzymes in the body,7 thus providing further protection,8 which vitamin C cannot do. Interestingly, vitamin C intake at high levels may actually prevent this upregulation from occurring.9

Similarities between plant based antioxidants  and molecular hydrogen?

  • plant based antioxidants  and molecular hydrogenare both natural to the body.10  (neither artificial nor synthetic)
  • plant based antioxidants  and molecular hydrogen are both potential keys to longevity.11   and promote health and wellness.

Differences between plant based antioxidants  and molecular hydrogen?

  • Molecular hydrogen only scavenges the bad free radicals.12
  • Molecular hydrogen leaves no waste product after neutralizing a free radical.
  • Molecular hydrogen also increases our body’s own antioxidant systems.7
  • Molecular hydrogen also acts as a signaling molecule, thus having many other benefits.13
  • Molecular hydrogen is the smallest molecule, and can easily enter the cells.14  (Note: H2 only weighs 2 g/mole vs. vitamin C at 176.2 g/mol).5
  • Molecular hydrogen has no known toxic effects, even at high intakes.15
  • Molecular hydrogen is easily consumed with no additional calories.


Molecular hydrogen doesn’t replace antioxidants contained in natural foods, but truly works in conjunction with them as well as offers additional benefits.



1. Matarese, L. E., & Gottschlich, M. M. (1998). Contemporary nutrition support practice: a clinical guide. WB Saunders.

2. Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., & Levine, M. (2008). Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proceedings of the National Academy of Sciences, 105(32), 11105-11109.

3. Arrigoni, Oreste, and Mario C. De Tullio. “Ascorbic acid: much more than just an antioxidant.” Biochimica et Biophysica Acta (BBA)-General Subjects 1569, no. 1 (2002): 1-9.

4. Murad, S., D. Grove, K. A. Lindberg, G. Reynolds, A. Sivarajah, and S. R. Pinnell. “Regulation of collagen synthesis by ascorbic acid.” Proceedings of the National Academy of Sciences 78, no. 5 (1981): 2879-2882.

5. Harris, D. C. (2010). Quantitative chemical analysis. Macmillan.

6. Washko, P. W., Wang, Y. A. O. H. U. I., & Levine, M. (1993). Ascorbic acid recycling in human neutrophils. Journal of Biological Chemistry, 268(21), 15531-15535.

7. KAWAMURA, T., WAKABAYASHI, N., SHIGEMURA, N., HUANG, C. S., MASUTANI, K., TANAKA, Y., NODA, K., PENG, X., TAKAHASHI, T., BILLIAR, T. R., OKUMURA, M., TOYODA, Y., KENSLER, T. W. & NAKAO, A. (2013). Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol304, L646-56.

8. XIE, K., YU, Y., HOU, L., CHEN, H., HAN, H., XIONG, L. & WANG, G. (2012). Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia108, 538-539.

9. Gomez-Cabrera, M. C., Domenech, E., & Viña, J. (2008). Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine, 44(2), 126-131.

10. CHRISTL, S. U., MURGATROYD, P. R., GIBSON, G. R. & CUMMINGS, J. H. (1992). Production, metabolism, and excretion of hydrogen in the large intestine. Gastroenterology102, 1269-77.

11. ZHANG, J. Y., LIU, C., ZHOU, L., QU, K., WANG, R. T., TAI, M. H., LEI, J. C. W. L., WU, Q. F. & WANG, Z. X. (2012). A Review of Hydrogen as a New Medical Therapy. Hepato-Gastroenterology59, 1026-1032.

12. OHSAWA, I., ISHIKAWA, M., TAKAHASHI, K., WATANABE, M., NISHIMAKI, K., YAMAGATA, K., KATSURA, K., KATAYAMA, Y., ASOH, S. & OHTA, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med13, 688-694.

13. DIXON, B. J., TANG, J. & ZHANG, J. H. (2013). The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Med Gas Res3, 10.

14. OHTA, S. (2011). Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des17, 2241-52.

15. OHNO, K., ITO, M. & ICHIHARA, M. (2012). Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxidative Medicine and Cellular Longevity2012, 353152.

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