Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)-6, and IL-17. Effective treatments, including pathogenesis-based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been investigated, it remains to be fully elucidated; ROS-targeted therapeutic strategies are also lacking at present. Therefore, the objective of the present study was to assess whether molecular hydrogen H2, a ROS scavenger, has a therapeutic effect on psoriasis-associated inflammation by reducing hydroxyl radicals or peroxynitrite in the immunogenic psoriasis cascade.
Three methods were used to administer molecular hydrogen H2: Drop infusion of saline containing 1 ppm H2 ( molecular hydrogen H2-saline), inhalation of 3% molecular hydrogen H2 gas, and drinking of water containing a high concentration (5-7-ppm) of H2 (high-H2 molecular hydrogen water).
Treatment efficacy was estimated using the disease activity score 28 (DAS28) system, based on C-reactive protein levels, and the psoriasis area and severity index (PASI) score, determined at baseline and following each molecular hydrogen H2 treatment.
Furthermore, levels of TNFα, IL-6, and IL-17 were analyzed. The DAS28 and PASI score of the three patients decreased during molecular hydrogen H2 treatment, regardless of the administration method. The psoriatic skin lesions almost disappeared at the end of the treatment.
IL-6 levels decreased during molecular hydrogen H2 treatment in Case 1 and 2.
IL-17, whose concentration was high in Case 1, was reduced following molecular hydrogen H2 treatment, and TNFα also decreased in Case 1.
In conclusion, molecular hydrogen H2 administration reduced inflammation associated with psoriasis in the three cases examined and it may therefore be considered as a treatment strategy for psoriasis-associated skin lesions and arthritis.
.Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
- 1Department of Rheumatology and Orthopaedic Surgery, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan.
- 2Department of Dermatology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan.
- 3MiZ Company, Fujisawa, Kanagawa 251‑0871, Japan.
- 4Department of Radiology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan.
- 5Department of Internal Medicine, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan.
- 6Department of Orthopaedic Surgery, Kyushu University, Higashi‑Ku, Fukuoka 812‑8582, Japan.
- 7Department of Cardiology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan.
- 8Midorino Clinic, Higashi‑ku, Fukuoka 813‑0025, Japan