Molecular Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
We have found that molecular hydrogen (dihydrogen; H2) water has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters.
The objective of this study was to characterize the effects of molecular hydrogen H2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome.
Serum analysis showed that consumption of molecular hydrogen H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.
Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum.
In addition, we found molecular hydrogen water H2 significantly improved HDL functionality assessed in four independent ways, namely:
i) protection against LDL oxidation,
ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells,
iii) stimulation of cholesterol efflux from macrophage foam cells, and
iv) protection of endothelial cells from TNF-α-induced apoptosis.
Further, we found consumption of molecular hydrogen H2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL.
In conclusion, supplementation with molecular hydrogeb H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome
- Song G1, Li M, Sang H, Zhang L, Li X, Yao S, Yu Y, Zong C, Xue Y, Qin S. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.
- 1, Key Laboratory of Atherosclerosis in Universities of Shandong, Shandong, China.
- PMID: 23610159
- PMCID: PMC3679390
- DOI: 10.1194/jlr.M036640
- [Indexed for MEDLINE]