Molecular  Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

We have found that molecular hydrogen (dihydrogen; H2) water has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters.

The objective of this study was to characterize the effects of molecular hydrogen H2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome.

Serum analysis showed that consumption of molecular hydrogen H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.

Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum.

In addition, we found molecular hydrogen water H2 significantly improved HDL functionality assessed in four independent ways, namely:

i) protection against LDL oxidation,

ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells,

iii) stimulation of cholesterol efflux from macrophage foam cells, and

iv) protection of endothelial cells from TNF-α-induced apoptosis.

Further, we found consumption of molecular hydrogen H2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL.

In conclusion, supplementation with molecular hydrogeb H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525017/