Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis -evoked oxidative stress as indicated by lipid peroxidation, hemolysis, and overexpression of proinflammatory cytokines in hemodialysis patients:
We explored whether alkaline ionized water/electrolyte-reduced water (ERW) could palliate chronic hemodialysis HD-evoked erythrocyte impairment and anemia.(Chronic hemodialysis (HD) patients increase erythrocyte susceptibility to hemolysis and impair cell survival).
43 patients undergoing chronic hemodialysis were enrolled and received alkaline ionized water/electrolyte-reduced water ERW administration for 6 month. We evaluated oxidative stress in blood and plasma, erythrocyte methemoglobin (metHb)/ferricyanide reductase activity, plasma metHb, and proinflammatory cytokines in the chronic hemodialysis patients without treatment (n=15) or with vitamin C (VC)- (n=15), vitamin E (VE)-coated dialyzer (n=15), or alkaline ionized water/electrolyte-reduced water ERW treatment (n=15) during an hemodialysis HD course.
The patients showed marked increases (15-fold) in blood reactive oxygen species, mostly H(2)O(2), after hemodialysis without any treatment. hemodialysis resulted in decreased plasma Vitamin C, total antioxidant status, and erythrocyte metHb/ferricyanide reductase activity and increased erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and plasma metHb.
Antioxidants treatment significantly palliated single hemodialysis course-induced oxidative stress, plasma and RBC PCOOH, and plasma metHb levels, and preserved erythrocyte metHb /ferricyanide reductase activity in an order Vitamin C>Electrolyte Reduced Water>Vitamin E-coated dialyzer.
However, Electrolyte Reduced Water had no side effects of oxalate accumulation easily induced by Vitamin C.
Six-month Electrolyte Reduced Water treatment increased hematocrit and attenuated proinflammatory cytokines profile in the hemodialysis patients.
In conclusion, Electrolyte Reduced Water treatment administration is effective in palliating hemodialysis-evoked oxidative stress, as indicated by lipid peroxidation, hemolysis, and overexpression of proinflammatory cytokines in hemodialysis patients.