Clinical trial (on humans) – Molecular hydrogen on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated MYOCARDIAL INFARCTION

Abstract

BACKGROUND:

Hydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI).

We designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI).

Methods and Results:The 20 patients with an initial diagnosis of STEMI were assigned to either an HI group (1.3% H2with 26% oxygen) or a control group (26% oxygen).

There were no HI-related severe adverse events.

In the full analysis set, the cardiac salvage index as evaluated using cardiac magnetic resonance imaging at 7 days after primary percutaneous coronary intervention (PCI), showed no significant between-group difference (HI: 50.0±24.3%; control: 60.1±20.1%; P=0.43). However, the improvement from day 7 in the HI group was numerically greater than that in the control group in some of the surrogate outcomes at 6-month follow-up, including the LV stroke volume index (HI: 9.2±7.1 mL/m2; control: -1.4±7.2 mL/m2; P=0.03) and the LV ejection fraction (HI: 11.0%±9.3%; control: 1.7%±8.3%; P=0.11).

CONCLUSIONS:

The first clinical study has shown that hydrogen inhalation HI during PCI is feasible and safe and may also promote LV reverse remodeling at 6 months after STEMI. The study was not powered to test efficacy and a further large-scale trial is warranted. (Clinical trials registration: UMIN00006825).

 

Our comments: Molecular hydrogen-rich water generally shows a more prominent effect than molecular hydrogen gas, although the amount of hydrogen taken up by hydrogen water is ~100 times less than that given by hydrogen gas [11]. read more in this article

 

 

PMID:
28321000
DOI:
10.1253/circj.CJ-17-0105
[Indexed for MEDLINE]

Free full text

 2017 Jun 23;81(7):940-947. doi: 10.1253/circj.CJ-17-0105. Epub 2017 Mar 17.
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction- First Pilot Study in Humans.

Author information

1
Department of Cardiology, Keio University School of Medicine.
2
Center for Molecular Hydrogen Medicine, Keio University School of Medicine.
3
Clinical and Translational Research Center, Keio University Hospital.
4
Department of Emergency and Critical Care Medicine, Keio University School of Medicine.
5
Department of Radiology, Keio University School of Medicine.
6
Department of Organ Fabrication, Keio University School of Medicine.

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