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Austin Air purifiers – clinical trials 

 

The Austin Air Bedroom Machine® air purifier was used in clinical trials at the University of John Hopkins to reduce Nitrogen Dioxide levels in the homes of local residents. Nitrogen Dioxide (NO2) is a gas often present in homes where there are gas stoves. High levels of NO2 are particularly dangerous for people with COPD. The gas can dramatically increase symptoms of coughing, wheezing and chest tightness.
The results were dramatics. NO2 dropped in the kitchen by 27% and continued to stay low for the length of the study. Within a week NO2 levels in the bedroom dropped by 23%.

In a second study at John Hopkins, the Austin Air Bedroom Machine® air purifier was placed in the homes of women, living with a smoker, who were either pregnant or with very young babies. Again the results were impressive. It was clinically proven that running an Austin Air Bedroom Machine® air purifier will effectively remove indoor pollutants from the home, including nicotine.

The Austin Air Allergy Machine® was selected for use in a clinical trial at the Cincinnati Children’s Hospital Medical Centre. The team monitored a group of children with asthma who were regularly exposed to second hand smoke. The aim of the study was to determine how the use of our air cleaners could help to reduce the number of times the children went to hospital. The results were clear, running one of our air purifiers in the children’s bedrooms while they slept, reduced their hospital visits by nearly 20%.

Read the clinical trials using Austin Air purifiers  outcomes:

Johns Hopkins Austin HEPA AIR purifier Second hand smoke 2018

Johns Hopkins HEPA Austin air filter NO2 study.docx

HEPA Austin air cleaners pedriatic study- asthma symptoms children exposed to second hand smoking summary

Johns Hopkins Inhale #1 In Home Particle Levels and Asthma Morbidity

Order the only Clinically Proven, Medical Grade Air Purifiers-made in USA.

Austin Air Healthmate air purifier was selected as the TOP AIR PURIFIER for chemical and VOC air filtration. after extensive testing along with over 100 other air purifiers at Battelle Laboratories, Aberdeen,MD in 2000
Recommended by the Red Cross, FEMA and the U.S. Department of Housing and Urban Development (HUD) to combat the negative health effects of ash, chemicals, VOCs and other miscellaneous airborne particulates released into the air following the 911 attack in 2001.
In 2002 following the Battelle Labs tests, Austin Air is selected by the U. S. government for the largest deployment of air purifiers in the world in order to protect residents of Anniston, Alabama during the elimination of chemical weapons

about Austin Air purifiers

About Austin Air  purifiers

 

Nearly 3 decades ago, Richard Taylor founded the company Austin Air Systems. Introducing medical grade HEPA air purification to residential customers.

He noticed asthma attacks were more frequent at night as hormonal changes take place and lying down causes the airways to narrow. Together these factors increase the chance of a night time asthma attack. Back then, the only advice doctors had to offer was to avoid asthma triggers like bedding and carpeting or take medication. He knew there had to be a better solution.

Clinical studies(see below) had shown that HEPA air filtration, used in hospitals at that time, was effective at removing contaminants from the environment. So he developed the first HEPA air purifier, designed for domestic use.

To this day, it is still the MOST EFFECTIVE AIR PURIFIER ON THE MARKET

 

Built for family first.

The Austin Air Healthmate was born out of necessity as President, Richard Taylor, undertook the task of improving what many doctors and specialists couldn’t; his wife’s quality of life.

Since his wife, Joyce, was a child, she had difficulty breathing. An endless round of doctors and specialists didn’t make any difference; neither did medications or dietary changes. She suffered from this debilitating condition for years, until Richard realized the obvious. The air Joyce was breathing was contaminated.

Drawing upon technology used in medical facilities, Richard reproduced the only environment where Joyce had relief of her symptoms, “the hospital clean room”. Using True Medical HEPA, surrounded with Activated Carbon he created a filter that addressed all the issues related to environmental particulate contamination and chemical toxicity. Within a week Joyce was finally sleeping undisturbed through the night.

Today, at 480,000 square feet Austin has the largest air cleaner manufacturing facility in the world, producing everything in house from filter, to metal forming, to the final paint.

Austin air is extremely proud that the Healthmate is the air cleaner of choice by leading doctors throughout the United States and many other parts of the world. As a matter of fact, there is hardly a country in the world today, where an Austin Air cleaner is not hard at work cleaning the air in someone’s home.

We’re proud to be on the cutting edge of the air purification industry. Here are a few key dates in our history:

In 1990 Austin Air Systems, Limited is formed in Buffalo, New York. The flagship air purifier, the Austin HealthMate®, is released. Using True Medical Grade HEPA and granular activated carbon for air filter, it is the first domestic air purifier to remove a broad range of contaminants including chemicals, gases and Volatile Organic Compounds (VOC’s).

In 1992 Austin Air is featured in medical and health newsletters including Dr. Whitaker’s Health & Healing. Proven to remove 99.97% of particles larger than 0.3 microns and 95% of particles larger than 0.1 microns.

In 2000 the Austin HealthMate® undergoes extensive testing along with over 100 other air purifiers at Battelle Laboratories, Aberdeen,MD.It is selected as the TOP AIR PURIFIER for chemical and VOC air filtration.

In 2001  After the 911 attack, Austin Air products are recommended by the Red Cross, FEMA and the U.S. Department of Housing and Urban Development (HUD) to combat the negative health effects of ash, chemicals, VOCs and other miscellaneous airborne particulates released into the air after the attack.

In 2002 following the Battelle Labs tests, Austin Air is selected by the U. S. government for the largest deployment of air purifiers in the world in order to protect residents of Anniston, Alabama during the elimination of chemical weapons.

In 2010 Austin Air receives the California Environmental Protection Agency’s Air Resources Board certification.This confirms Austin Air purifiers are well under the standards for safe ozone emissions.

In 2016 The Austin Air HealthMate Plus® is deployed to many thousands of residents of Porter Ranch, California and the surrounding Aliso Canyon area to help protect against the effects of the Southern California natural gas leak.

Year after year, Austin Air purifiers are chosen to filter the contaminants released into the air during the wildfire season. 2017 was a particularly brutal year for residents of California and surrounding states – the wildfire season started very early and continued through the end of the year.

Of course, there are many other important dates and product innovations that we’re very proud of.  We have been developing and manufacturing air cleaners for nearly 30 years. It’s all we do. We understand the science. We understand what our customers need.

Sold in over 100 countries, we have created a line of robust, reliable, American made products that you can trust.

Read the clinical trials using Austin Air purifiers  outcomes

Integrity in Construction

The Air purifier Body 
Austin Air produces all of its products(air purifiers and filters) with solid steel construction and non-toxic powder coated paint for strength, reliability and longevity.

The Air Filter
Austin Air incorporates the only trusted air filtering technology used in hospitals and operating rooms. For an air filter to be effective, gases and sub-micron particles must be removed from the air. That’s why you’ll find True Medical Grade HEPA and Activated Carbon in every Austin Air filter.

True HEPA air filter
The True HEPA air filter was developed by the Atomic Energy Commission specifically to protect the Human Respiratory System (nose, mouth, throat, lungs) from radioactive dust particles. Austin Air takes it a step further, incorporating True Medical Grade HEPA with 99.97% efficiency down to 0.3 microns and 95% efficiency down to 0.1 microns. True Medical Grade HEPA is the most efficient particulate air filtering media on the market.

Activated Carbon in the air filter 
Activated Carbon is used to remove Volatile Organic Compounds (VOC’s); noxious gases and chemicals, including smoke & smoke odor. Austin Air filters can use up to 15 lbs of Activated carbon in one filter wich is UNmatched on the market

Powder Coated – Not Painted

Austin Air cleaners are powder coated not painted. This gives the products an unsurpassed finish without the harmful off gassing that painted products can produce. In fact you will find that the control knob, wheels and fan are the only plastic components we use. This is great news for the chemically sensitive. We feel that am air purifier that offers relief to allergy and asthma sufferers shouldn’t contribute to the problem.

 

Designed from the inside out.

The engineers at Austin Air concentrated on developing the most critical component of the air cleaner first; the air filter.

Austin Air’s 360-degree intake system draws air into all sides of the air cleaner, maximizing efficiency and delivering more clean air faster.

Every minute, 250 cubic feet of air is processed by a 4-stage air filter that progressively removes contaminants out of the air.

This process enables Austin Air cleaners to:

  • Achieve the highest levels of performance.
  • Attain superior air flow rates.
  • Sustain a longer air filter life (5-years under normal residential use).
  • Increase the life expectantly of the Medical Grade HEPA, the most critical media in the air filtration process.

 

5 year Warranty
Austin Air has taken the risk out of the buying and stands by their products (air purifiers and filters) with a 5-year warranty on the material and craftsmanship and 5-year pro-rated warranty on the air filter. Customers always have peace of mind when purchasing an Austin Air cleaner

 

Integrity in Business

Austin Air has made a conscious decision to keep Americans employed by keeping their manufacturing facility in the United States. We feel that every company has an obligation to carefully examine the social, economic and moral costs of sending jobs offshore. At Austin Air we believe that American workers still build the best products, that corporations can still make a healthy profit manufacturing in the United States and that the benefits of staying in America far outweigh the costs.

When a company chooses to go offshore to manufacture a product, they are motivated by one thing…greed. As a result, our economy suffers through lost jobs and money, and the American consumer is short changed. The benefits of these corporate cost savings are rarely passed on to the consumer and the product is now of a lesser quality. If this were not true, your running shoes would last 5 times longer and would never cost over $50 a pair. The next time you buy a product made in China, ask yourself, “Why is this costing as much as it did when it was made in the USA and how is this country going to prosper when our own corporations have no loyalty to us?”

After pioneering and leading the air cleaning industry for more than 15 years, Austin Air maintains the largest air cleaner manufacturing facility in the world, manufacturing everything in-house. From the filter, to metal forming, to powdercoating, to final assembly, every Austin Air cleaner is proudly made in the USA. 

Order the only Clinically Proven, Medical Grade Air Purifiers-made in USA.

Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms

Abstract

In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefinite complaint. The object of this study is to evaluate the effect on health, including gastrointestinal symptoms, when a person without abdominal indefinite complaint, etc., drinks AEW on a daily basis. A double-blind, randomized controlled trial has been designed. Four-week period of everyday water drinking, PW drinking group: drink purified tap water as a placebo, AEW drinking group: drink alkaline electrolyzed water which made by electrolysis of purified tap water. Before the experiment and after the 4-week period of water drinking, Blood tests, physical fitness evaluations, and questionnaire evaluations is conducted. In this study, we did not specifically select patients with gastrointestinal symptoms. Sufficiently clear effect could not be confirmed. But the stools were more normal, and, as shown in the previous report, that drinking AEW is considered to contribute to intestinal normalization. In addition, when drinking AEW, a high proportion of the respondents said that they felt they were able to sleep soundly, and the proportion of subjects who answered that they felt good when awakening increased. The effect of reducing oxidative stress, thus allowing for improved sleep, was exhibited by drinking AEW containing hydrogen, which is considered to be an antioxidant substance. This research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018.

Keywords: alkaline electrolyzed water, gastrointestinal symptoms, hydrogen-dissolved water, physical fitness evaluations, questionnaire evaluations, functional beverage

Introduction

In Japan, water which is obtained on the cathode side by the electrolysis of tap water is called alkaline electrolyzed water (AEW) or reduced hydrogen water. Improvement of gastrointestinal symptoms by ingesting AEW has been confirmed by Japanese researchers. For example, Naito et al. reported the inhibitory effect of AEW ingestion on gastric mucosal disorder caused by aspirin, and Hayakawa et al.reported the inhibitory effect of AEW ingestion on abnormal intestinal fermentation. Tashiro et al.examined the effect of ingesting AEW or purified tap water (PW; as a placebo) at a rate of at 500 mL per day for 4 weeks in patients who had abdominal pain such as heartburn, stomach discomfort, abdominal bloating, diarrhea, constipation, etc., and reported that the results of the AEW group were superior to those of the placebo group., From these results, apparatus that produce AEW have been approved as medical devices by the Japanese Ministry of Health, Labour and Welfare. AEW is thought to be effective for functional gastrointestinal disorders.

Since AEW is produced by electrolyzing water, hydroxide ions, which are alkaline in nature, are generated. Hydrogen molecules are also generated on the electrode surface and dissolved in water. Therefore, AEW is alkaline water containing hydrogen. In conventional efficacy studies, evaluations with respect to ingesting AEW have typically been conducted focusing on the alkalinity of the water.,,, In recent years, however, the assumed effectiveness of the antioxidant effect of dissolved hydrogen on various diseases has been reported.,,,,,,,, Nevertheless, some users of AEW apparatus do not have any definite abdominal symptoms. In many cases, they are drinking AEW on a daily basis to improve their health, and many users also feel health benefits such as improvement in exercise capacity. These may be thought to be due to the action of dissolved hydrogen. There have been no researched studies of these in detail. The object of this study is to evaluate the effect of daily ingestion of AEW on health, including gastrointestinal symptoms, in subjects without any definite abdominal symptoms.

Participants and Methods

Participants

Healthy men and women (20–60 years) who use the Osaka City Citizen Health Development Consultation Center were selected as test subjects to determine the health effect of daily AEW ingestion. It was aimed to clarify whether general subjects without gastrointestinal symptoms have another good effect besides gastrointestinal symptoms by drinking AEW which is good for gastrointestinal symptoms. We explained this purpose to the subjects and asked for research participation. Written informed consent was obtained from all subjects. All procedures used in this research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018. This study follows the Consolidated Standards of Reporting Trials (CONSORT) guidelines. A double-blind, randomized controlled trial has been designed, and the research design is shown in Figure 1.

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Research design.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Subjects were randomly divided into two groups, with an AEW group (n = 30) and a PW group (n = 30). Blood tests, physical fitness evaluations, and questionnaire evaluations were conducted before the experiment was initiated. Subjects were provided with AEW apparatus that had been modified to produce only AEW or PW. They ingested 500 mL or more of freshly produced AEW or PW per day (they were required to ingest 200 mL immediately after awakening, and 300 mL or more during the rest of the day). After the end of the four-week period, blood tests, physical fitness evaluations, and questionnaire evaluations were conducted again to check whether the ingestion of AEW for four weeks had beneficial effects on the health of the subjects.

Blood sample/urinalysis

General blood test: Red blood cell count, white blood cell count, hemoglobin, hematocrit, and platelet count.

Blood biochemical examination: Total protein, albumin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), γ-GTP, total cholesterol, high-density lipoprotein (HDL), cholesterol, low-density lipoprotein (LDL) cholesterol, neutral fat, uric acid, creatinine, and blood sugar.

Urinalysis: Urine sugar, urine protein, urine occult blood, and urine pH.

Physical measurements

Right/left grip strength, right/left leg muscle strength, vertical jump, whole body reaction time, standing time on one leg with eyes closed, sit-up, seated forward bend, and resting blood pressure.

Questionnaire variables

Gastrointestinal symptoms (stomachache, heartburn, heavy stomach, lower abdominal pain, bloated stomach), urinary frequency, condition of the stools (fecal properties and bowel movement), and physical condition (sleep quality and upon awakening).

Statistical analysis

In the blood data, the urinalysis and physical measurement values, the statistical significance of the average difference (before and after AEW, PW drinking) was analysed using a paired t-test (Statcel 4 Software [OMS Publishing, Saitama, Japan). The questionnaire data (before and after AEW, PW drinking) was analysed by the Wilcoxon signed-rank test using the same Statcel 4 software. Differences for which Pvalues of < 0.05 and < 0.01 were inferred as significant.

Results

Conditions of subjects and water quality

Subjects with abdominal symptoms such as heartburn, stomach discomfort, abdominal bloating, diarrhea, and constipation were used in the study previously performed., For the current study, subjects aged 20 to 69 years were randomly selected among medical checkup examinees who visited the Osaka City Citizen Health Development Consultation Center, and then divided into two groups. One group ingested PW while the other ingested AEW. Neither the subjects nor the experimenters knew which group the subjects belonged to. Figure 2 shows that no significant differences were found in dispersion of mean values and distribution values.

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Age distribution of subjects.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Each subject was provided with an AEW apparatus that had been modified to either produce or not produce AEW, and asked to install it at their home. In order to verify the quality of the drinking water, the water produced by the apparatus was taken into aluminum containers and collected when the subjects came in for measurement. Figure 3 shows the water quality distribution of each drinking water.

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Water quality distribution of two types of drinking water.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Because we selected subjects who live in or around Osaka City, the tap water from either the same or a nearby water source was used for the evaluation. For this reason, the tests have been conducted using water of equivalent quality and which shows little bias in the distribution of ions.

Regarding the water before and after the electrolysis, the pH was 7.6 ± 0.2 for the PW group, and 9.2 ± 0.2 for the AEW group. Dissolved hydrogen concentration was not measurable at the subjects’ houses because hydrogen easily escapes water. However, for non-electrolyzed and electrolyzed tap water from the same water source and using the same water apparatus, the hydrogen concentration was confirmed as 0 mg/L in the PW group and 0.2 mg/L for the AEW group for the characteristics of the device.

Comparison of hematological values

The hematological data of subjects in the PW group and the AEW group were compared before and after the four-week period, but no significant differences were observed in both groups. This is consistent with the contents of the previous report. However, the HDL cholesterol level, a newly measured value this time, of the AEW group showed a tendency to increase with P = 0.097, as shown in Figure 4.

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Change in HDL cholesterol before and after drinking.

Note: (A) alkaline electrolyzed water (AEW) drinking group, (B) purified tap water (PW) drinking group. HDL: High-density lipoprotein.

Comparison of data related to physical abilities

For the seated forward bend, vertical jump, right/left grip strength, and sit-up, there was no significant difference before and after the 4-week period for both the PW group and the AEW group.

Regarding the whole body reaction time, no significant differences were observed before and after the 4-week period in the case of the PW group, as seen in Figure 5B. However, a significant difference (decrease) (P < 0.05) was observed in the AEW group, as seen in Figure 5A. As for standing time on one leg with eyes closed, longer times were observed in the AEW group (P = 0.09), as seen in Figure 6A.

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Change in whole body reaction time before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group; (B) purified tap water (PW) drinking group.

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Changes in the standing time on one leg with eyes closed before and after drinking.

Note: (A) alkaline electrolyzed water (AEW) drinking group, (B) purified tap water (PW) drinking group.

Questionnaire to subjects

As for the questionnaire items, we asked the subjects to provide answers in 3 to 5 points about gastrointestinal symptoms (Table 1), defecation and urination (Table 2), and physical condition (Table 3).

Table 1

Gastrointestinal symptoms

Item 1 2 3 4
Stomachache Not at all Slightly Quite a lot Very much
Heartburn Not at all Slightly Quite a lot Very much
Heavy stomach Not at all Slightly Quite a lot Very much
Lower abdominal pain Not at all Slightly Quite a lot Very much
Bloated stomach Not at all Slightly Quite a lot Very much

Note: Scoring 1 to 4, where: Not at all = 1, and Very much = 4.

Table 2

Defecation and urination

Item 1 2 3 4 5
Uninary frequency Very often Often Sometimes Occasionally Rarely
Fecal properties Hard Slightly hard Normal Slightly soft Soft
Bowel movement Very good Good Normal Bad Very bad

Table 3

Physical conditionn

Item 1 2 3
Sleep quality Good Neither nor Bad
Waking up Good Neither nor Bad

Note: Scoring 1 to 3, where: Good = 1, and Bad = 3.

First, as seen in Figures 77 to to11,11, as for gastrointestinal symptoms, sufficiently clear effect could not be confirmed in this study. Next, as seen in Figure 12, the urinary frequency significantly increased in both groups, likely due to an increase in urine volume resulting from water ingestion. Regarding bowel movement, the stools slightly changed from slightly soft to normal or slightly hard, or from soft to normal (P < 0.05) in the AEW group, as can be seen in Figure 13A. There was no difference between subjects of the two groups who had answered that they were in “good” or “bad” physical condition.

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Change in stomach ache before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in bloated stomach before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in urinary frequency before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Changes in the condition of stools before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Change in heartburn before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

An external file that holds a picture, illustration, etc. Object name is MGR-8-160-g009.jpg

Change in heavy stomach before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in lower abdominal pain before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

Regarding sleep quality, there was a significant increase (P < 0.01) in the number of AEW group subjects who responded that they were able to sleep well, as shown in Figure 14A, and there was a significant increase (P < 0.05) in the number of subjects from the same group who said that they felt good upon awakening, as seen in Figure 15A.

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Change in sleep quality before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Changes in the state of getting up before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

Discussion

In Japan, AEW apparatus have been approved as medical devices, and ingesting AEW has been found to be effective in relieving gastrointestinal symptoms. A clinical evaluation of this effect was conducted with patients with gastrointestinal symptoms (heartburn, stomach discomfort, and abdominal symptoms such as abdominal bloating, diarrhea, and constipation).

Antioxidant action by hydrogen and gastric acid neutralization by alkaline pH have been considered. In addition, recent studies have shown that the intestinal bacterial flora distribution changes. It seems that these are involved in the normalization of the gastrointestinal activity. However, for this study, patients with gastrointestinal symptoms were not specifically selected. As for these as well as the previous results, in general, there was no difference in the hematological values between the PW group and the AEW group. However, the newly measured HDL cholesterol value showed a tendency to increase with P = 0.097. The increase in HDL cholesterol by ingesting water containing hydrogen is reported by Gadek and colleagues. The effect of hydrogen can be considered to have had an effect in the AEW group this time as well.

As for gastrointestinal symptoms—which showed a significant difference during the previous study (significant improvement of abdominal symptoms and improvement of abnormal bowel movement),—sufficiently clear effect could not be confirmed by this study because the subjects did not show gastrointestinal symptoms, and very few of them responded that they had abnormal abdominal symptoms and bowel movement before participating in this study. Therefore, we believe this is the reason the answers of the subjects were the same before and after their participation in the study.

However, with respect to bowel movement, the stools slightly changed from soft to normal or slightly hard, or from loose to normal in the AEW group. This reflects that the stools are more normal, and, as shown in the previous report, that ingesting AEW is considered to contribute to intestinal normalization.,,Regarding items other than the gastrointestinal tract, a high proportion of the respondents said that they felt they were able to sleep well, and the proportion of subjects who answered that they felt good when awakening increased. Various studies on the relationship between the ingestion of antioxidant substances and the condition of sleep have been undertaken, and the effect of reducing oxidative stress, thus allowing for improved sleep quality, is exhibited by ingesting AEW containing hydrogen, which is considered an antioxidant substance.

Regarding sports performance, various reports on the effects of sleep on sports performance have concluded that willingly sleeping longer can lead to faster running, shortened reaction time, and improved motivation during practice and games. Improved sleep quality by ingesting AEW is, therefore, believed to help reduce fatigue, ensure appropriate endurance recovery, and improve overall sports performance.

The findings of this study indicate that ingesting AEW on a daily basis improves health and exercise capacity, even in healthy people who do not have gastrointestinal symptoms.

Footnotes

Funding: The study was supported by a grant from Matsushita Electric Works Co., Ltd. Home Appliances R&D Center (to HN).

Conflicts of interest

The corresponding author (YT) is a salaried employee of the Panasonic Corporation. One of the authors (SY) was a salaried employee of the Panasonic Corporation. This study does not alter our adherence to Medical Gas Research policies on sharing data and materials. Another authors (KI and HN) report no conflict of interest related to this manuscript.

Financial support

The study was supported by a grant from Matsushita Electric Works Co., Ltd. Home Appliances R&D Center (to HW).

Institutional review board statement

All procedures used in this research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018.

Declaration of participant consent

The authors certify that they have obtained participant consent forms. In the form, participant have given their consent for their images andother clinical information to be reported in the journal. The patients understand that their names and initials not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Reporting statement

This study follows the Consolidated Standards of Reporting Trials (CONSORT) guidelines.

Biostatistics statement

The statistical methods of this study were reviewed by the biostatistician of the Osaka City University, Osaka, Japan.

Copyright license agreement

The Copyright License Agreement has been signed by all authors before publication.

Data sharing statement

Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices). Study protocol and informed consent form will be available immediately following publication, without end date. Results will be disseminated through presentations at scientific meetings and/or by publication in a peer-reviewed journal. Anonymized trial data will be available indefinitely at www.figshare.com.

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Link to Publisher's site
. 2018 Oct-Dec; 8(4): 160–166.
Published online 2019 Jan 9. doi: 10.4103/2045-9912.248267
PMCID: PMC6352572
PMID: 30713669
Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms

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role of molecular hydrogen H2 water in the regression of hypercholesterolemia and atherosclerosis

Abstract

CONTEXT:

We have found that hydrogen (dihydrogen [H2] (water)) decreases plasma low-density lipoprotein (LDL) cholesterol levels and improves high-density lipoprotein (HDL) function in patients with potential metabolic syndrome in a before-after self-controlled study.

OBJECTIVE:

The purpose of this study was to further characterize the effects of H2-rich water (0.9 L/day) on the content, composition, and biological activities of plasma lipoproteins on patients with hypercholesterolemia and their underlying mechanisms in a double-blinded, randomized, and placebo-controlled trial.

DESIGN:

This was a case-control study.

SETTING:

The setting was the Zhoudian community, Tai’an, China.

PATIENTS:

A total of 68 patients with untreated isolated hypercholesterolemia were randomly allocated to either drinking H2-rich water (n = 34) or placebo water (n = 34) for 10 weeks.

RESULTS:

HDL isolated from the H2 group showed an increased ability to promote the ATP-binding cassette transporter A1-mediated cholesterol efflux ex vivo. Plasma pre-β-HDL levels were up-regulated although there were no changes in plasma HDL-cholesterol levels. Moreover, other HDL functions, assessed in protection against LDL oxidation, inhibition of oxidized-LDL-induced inflammation, and protection of endothelial cells from oxidized-LDL-induced apoptosis, were all significantly improved by H2 treatment. In addition, molecular hydrogen water H2 treatment increased the effective rate in down-regulating plasma levels of total cholesterol (47.06% vs 17.65%) and LDL cholesterol (47.06% vs 23.53%). Western blot analysis revealed a marked decrease in apolipoprotein B100 and an increase in apolipoprotein M in plasma of the molecular hydrogen water H2 group. Finally molecular hydrogen water H2 treatment resulted in a significant reduction in the levels of several inflammatory and oxidative stress indicators in whole plasma and HDL particles.

CONCLUSIONS:

H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects. The present findings highlight the potential role of H2 in the regression of hypercholesterolemia and atherosclerosis.

PMID:25978109
DOI: 10.1210/jc.2015-1321
 2015 Jul;100(7):2724-33. doi: 10.1210/jc.2015-1321. Epub 2015 May 15.
Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.
Song G1Lin Q1Zhao H1Liu M1Ye F1Sun Y1Yu Y1Guo S1Jiao P1Wu Y1Ding G1Xiao Q1Qin S1.

Author information

1
Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis (G.S., Q.L., H.Z., Y.Y., S.G., P.J., S.Q.), TaiShan Medical University, Tai’an, China 271000; Heart Center of TaiShan Medical University (G.S., Q.L., Y.W., Q.X., S.Q.), Tai’an, China 271000; Zhoudian Community (M.L., Y.S.), Daiyue District, Tai’an, China 271021; Tai’an He Ren Tang Hospital (F.Y.), Tai’an, China 271021; Department of Cardiology (Y.W., Q.X., S.Q.), Affiliated Hospital of Taishan Medical University, Tai’an, China 271000; and Institute of Public Health (G.D.), TaiShan Medical University, Tai’an, China 271000.

 

Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women

Abstract

BACKGROUND:

Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans.

AIM:

In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten (n = 10) middle-aged overweight women.

METHODS:

Volunteers received either hydrogen-generating minerals (supplying ~6 ppm of H2 per day) or placebo by oral administration of caplets for 4 weeks. The primary end-point of treatment efficacy was the change in the body fat percentage from baseline to 4 weeks. In addition, assessment of other body composition indices, screening laboratory studies, and evaluation of side effects were performed before and at follow-up. Clinical trial registration www.clinicaltrials.gov , ID number NCT02832219.

RESULTS:

No significant differences were observed between treatment groups for changes in weight, body mass index, and body circumferences at 4-week follow-up (P > 0.05). H2 treatment significantly reduced body fat percentage (3.2 vs. 0.9%, P = 0.05) and arm fat index (9.7 vs. 6.0%, P = 0.01) compared to placebo administration, respectively. This was accompanied by a significant drop in serum triglycerides after H2 intervention comparing to placebo (21.3 vs. 6.5%; P = 0.04), while other blood lipids remained stable during the study (P > 0.05). Fasting serum insulin levels dropped by 5.4% after H2 administration, while placebo intervention augmented insulin response by 29.3% (P = 0.01).

CONCLUSIONS:

It appears that orally administered H2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity.

 2018 Feb;187(1):85-89. doi: 10.1007/s11845-017-1638-4. Epub 2017 May 30.
Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.

Author information

1
Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.
2
Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia. sergej.ostojic@chess.edu.rs.
3
University of Belgrade School of Medicine, Belgrade, Serbia. sergej.ostojic@chess.edu.rs.
4
Applied Bioenergetics Laboratory, Faculty of Sport and PE, University of Novi Sad, Lovcenska 16, Novi Sad, 21000, Serbia. sergej.ostojic@chess.edu.rs.