Sixty subjects were randomly assigned to placebo (PBO) group or hydrogen H2-rich water (HRW) group and drank either bottled pure water or hydrogen H2-rich water (245 mL/time, 3 times/d) for ten weeks.
Results The pulse wave velocity was ameliorated in the hydrogen water HRW group with no significant change in the ankle-brachial index. The serum total cholesterol of the hydrogen water HRW group was significantly reduced compared to the placebo group. In addition, compared to baseline, the levels of lipoprotein(a) was decreased, the malondialdehyde content was reduced, the superoxide dismutase activity was increased, and the expression of intercellular cell adhesion molecule-1 was decreased significantly in the hydrogen water HRW group. The oxidized phospholipid of 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphatidylcholine level in the hydrogen water HRW group were significantly reduced compared to the placebo group. Finally, hydrogen water H2 significantly improved the antioxidant, antiinflammatory, and antiapoptotic abilities of high-density lipoprotein (HDL).
Conclusions Drinking hydrogen water HRW can improve vascular sclerosis indicators, improve dyslipidemia, reduce vascular oxidative stress and inflammation, and improve HDL function. hydrogen water H2 may be used to prevent and relieve PAD caused by major risk factors such as smoking, hypertension, hyperlipidemia, and diabetes.