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Drinking hydrogen water enhances ENDURANCE and relieves psychometric FATIGUE: a randomized, double-blind, placebo-controlled study 

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study


Acute physical exercise increases reactive oxygen species in skeletal muscle, leading to tissue damage and fatigue. Molecular hydrogen (H2) acts as a therapeutic antioxidant directly or indirectly by inducing antioxidative enzymes.

Here, we examined the effects of drinking hydrogen H2 water (H2-infused water) on psychometric fatigue and endurance capacity in a randomized, double-blind, placebo-controlled fashion.

In Experiment 1, all participants(humans) drank only placebo water in the first cycle ergometer exercise session, and for comparison they drank either hydrogen H2 water or placebo water 30 min before exercise in the second examination.In these healthy non-trained participants (n = 99), psychometric fatigue judged by visual analogue scales was significantly decreased in the hydrogen H2 water group after mild exercise. When each group was divided into 2 subgroups, the subgroup with higher visual analogue scale values was more sensitive to the effect of hydrogen water H2.

In Experiment 2, trained participants (n = 60) were subjected to moderate exercise by cycle ergometer in a similar way as in Experiment 1, but exercise was performed 10 min after drinking hydrogen H2 water. Endurance/fatigue were significantly improved/relieved in the hydrogen water H2 group as judged by maximal oxygen consumption and Borg’s scale, respectively.

Taken together, drinking hydrogen H2 water just before exercise exhibited anti-fatigue and improved endurance effects.



 2019 Jun 28:1-6. doi: 10.1139/cjpp-2019-0059. [Epub ahead of print]
Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study 1.

Author information

a Department of Health and Sports Science, Nippon Medical School, Musashino, Tokyo 180-0023, Japan.
b Fitness Club, Asahi Big S Mukogaoka, Kawasaki-city, Kanagawa pref. 214-0014, Japan.
c Hydrogen Health Medical Laboratory, Co., Ltd., Arakawa-ku, Tokyo 116-0001, Japan.
d Slovak Academy of Sciences, Centre of Experimental Medicine, Institute for Heart Research, Bratislava 84005, Slovak Republic.
e Molecular Hydrogen Institute, Enoch, UT 84721, USA.
f Department of Neurology Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

Effects of hydrogen rich water on prolonged intermittent EXERCISE


Peak power output (PPO), also known as “peak work rate” is a common measure of exercise intensity.

The Authors of this 2-weeks ‘ hydrogen /placebo water’ study (a cross over single-blind protocol -see footnotes for references) tested  8 trained male cyclists and measured multiple parameters(including mean and peak power output) on a regular basis(before and after 2 weeks cycle )


1 The athletes were given were provided daily with 2 liters of placebo normal water (pH 7.6, ORP +230 mV, H2 0 ppb) or 2 liters hydrogen rich water(pH 9.8, ORP -180 mV, H2 450 ppb)

2  AlkaViva H2 ionizers such as Vesta/Delphy H2 can produce up to 1600 ppb at ph<10  ).

The authors found that while in the placebo group, Peak Power Output  in absolute values decreased significantly at the last couple of sprints and in relative values and ΔPPO decreased significantly  in more than a couple of sprints,  it remained unchanged in the group that drunk hydrogen rich water . Thus they conclude drinking 2  liters of hydrogen rich water per day over a 2 week period may help to maintain peak power output in intense exercise such as repetitive sprints to exhaustion over 30 minutes.


read complete article on pubmed:


 2018 May;58(5):612-621. doi: 10.23736/S0022-4707.17.06883-9. Epub 2017 Apr 26.

Effects of hydrogen rich water on prolonged intermittent exercise.