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Molecular Hydrogen Water FAQ

Frequently Asked Questions about Molecular Hydrogen Water

  1. What is molecular hydrogen water?

Molecular hydrogen water or hydrogen-rich water ( hydrogen-enriched water)  means water (H2O) with dissolved hydrogen gas (H2) in it.  

  1. Isn’t ( molecular ) hydrogen gas explosive?

Yes, it is VERY explosive. Molecular hydrogen is the most energy-dense molecule by mass.  

But, when the molecular hydrogen gas is dissolved in water it is not explosive anymore,

Even when molecular hydrogen is in the air, it is only flammable above a 4.6% concentration by volume, which is not a concern when talking about molecular hydrogen  water.

 

  1. Doesn’t water H2O already have hydrogen in it  ?

The water molecule has 2 hydrogen atoms, chemically bound to the oxygen atom. This is different from the molecular hydrogen gas (H2), which is just two hydrogen atoms bound only to each other.The H2 -hydrogen molecules are not tied up to water H2O

In order for the dissolved molecular hydrogen gas (H2) to beneficial for humans, it must be in an unbound form, and therefore available for therapeutic benefit.

Virtually everything has hydrogen atoms in it, but those hydrogen atoms are chemically tied up with other things.  In molecular hydrogen rich water, the hydrogen molecule that is shown to be therapeutic is the available water dissolved hydrogen molecule in its diatomic form, called (dissolved diatomic) molecular hydrogen.

 

  1. I thought that if water “rich in hydrogen ”, it must be acidic?

If the water is rich in positive hydrogen ions (H+). then YES, water is acidic(pH<7).

But  when talking about molecular hydrogen rich water of , we’re talking about neutral (ph=7) hydrogen gas (H2), which is two hydrogen atoms tied together –  hydrogen in its diatomic molecular form.

It can be confusing to hear “hydrogen water” because we usually think of hydrogen (meaning the hydrogen ion, H+) as acidic, and that is basically the definition of pH.  The p stands for potential or power, meaning a mathematical exponent (in this case a logarithmic function), and the H stands for the hydrogen ion, which is just a proton and no electron. So pH literally means the logarithmic concentration of the hydrogen ion.

But when we say “molecular hydrogen rich  water” we are referring to diatomic hydrogen or molecular hydrogen, which is a neutral(ph=7) gas of H2 molecules (one H2 is made of 2 atoms of hydrogen bond into a  molecule),  that is dissolved in the water.

 

  1. I read that if you add hydrogen to water, then it makes hydrogen peroxide?

Molecular hydrogen (H2) gas does NOT bond to NOR react with the water molecules, it just dissolves into the water. Thus it does not create some novel molecule like H4O, which would in fact be chemically impossible to form. Water has the chemical formula H2O,  and hydrogen peroxide has the chemical formula H2O2, which by comparison contains an extra oxygen, not hydrogen.

Molecular hydrogen water and hydrogen peroxide are completely different.

 

  1. Since molecular hydrogen gas doesn’t dissolve very well in water, how can there even be enough for it to be beneficial?

It is true that molecular hydrogen is not very water soluble as it is a neutral, non-polar molecule with a solubility of 1.6 mg/L, which is relatively low.

But when we consider that molecular hydrogen is the lightest molecule in the universe, we really need to compare the number of molecules as opposed to the number of grams.

For reference, vitamin C (176.2 g/mole) weighs 88 times more than hydrogen gas (2 g/mole).

Therefore, molecular hydrogen rich water at a concentration of 1.6 mg/L would have more “antioxidant” molecules than 100 mg of vitamin C, as there are more total molecules in 1.6 mg of hydrogen compared 100 mg of vitamin C. That is, 0.8 mmoles of H2 vs. about 0.6 mmoles of vitamin C.

But more importantly, hundreds of scientific studies clearly show that these concentrations of molecular hydrogen in water are effective.

 

  1. Won’t any dissolved molecular hydrogen gas immediately evaporate out of the water?

Yes, molecular hydrogen as any gas does immediately start coming /evaporate out of the water, but it doesn’t just vanish immediately. Depending on the surface area, agitation, etc., the molecular hydrogen gas can stay in the water for a few hours or longer before it drops below a therapeutic level. 

 

  1. How much molecular hydrogen water should I drink to get the benefits?

That is the same question scientists are asking and is still under investigation. However, the human studies generally provide about 1-3 mg of molecular hydrogen H2, and these doses show statistically significant benefits. So, if your molecular hydrogen water has a concentration of 1 mg/L (equivalent to 1 ppm, parts per million), then 2 liters of molecular hydrogen water will give you 2 mg of H2. Although the effective concentration for some people and some diseases may be lower and/or higher, these doses are simply what have been seen to expert benefits. (see this article also).

 

  1. Does more molecular hydrogen equal more benefits?

Maybe, maybe not…. there is obviously a minimum required amount of molecular hydrogen (water )needed to offer any health benefits, which may vary from person to person. Importantly, it appears that you cannot get too much molecular hydrogen, as it doesn’t build up in your body—you just exhale it out.  In many cases there is a clear dose-dependent effect, meaning the more molecular hydrogen (water) the better or greater the effect. There are also many anecdotal reports that suggest that consuming more molecular hydrogen (water) may offer even more benefits. But more research needs to be done in this area.

 

  1. Is molecular hydrogen (water) safe (for consumption)?

YES. Molecular Hydrogen  gas (in water)  has been shown to be very safe at concentrations hundreds of times higher than what is being used for therapy.  Here are a few examples:

Molecular Hydrogen’s safety was first shown in the late 1800s, where molecular hydrogen gas was used to locate gunshot wounds in the intestines. The reports showed that there were never any toxic effects or irritation to even the most sensitive tissues.

Another good example of its safety is that  molecular hydrogen gas has been used in deep sea diving since 1943 (at very high concentrations) to prevent decompression sickness. Studies have shown no toxic effects from  molecular hydrogen when at very high levels and pressures of 98.87% H2 and 1.26% O2 at 19.1 atm.

Furthermore, molecular hydrogen gas is natural to the body because after a fiber-rich meal, our gut bacteria can produce liters of molecular hydrogen on a daily basis (which is yet another benefit from eating fruits and vegetables).

In short, molecular hydrogen gas is very natural to our bodies, not like  a foreign or alien substance that can only be synthesized in a chemistry lab.

  1. When was molecular hydrogen’s therapeutic benefits first discovered?

The earliest account of molecular hydrogen gas having medicinal properties was in 1798, for things like inflammation. But, it didn’t become a popular topic among scientists until 2007, when an article about the benefits of molecular hydrogen was published in the prestigious journal of Nature Medicine by Dr. Ohta’s group.

 

 

Molecular hydrogen water overview-definiton, benefits, research , studies ,safety

Molecular hydrogen water overview-definiton, benefits, research , studies  ,safety

molecular hydrogen water might sound new but it is not .

What is molecular hydrogen rich water ?molecular hydrogen  water or molecular hydrogen -rich water is water enriched or infused with dissolved  molecular hydrogen gas (molecular hydrogen  H2 NOT the H2 linked to O), also known as molecular hydrogen. 2 This means that hydrogen molecules or nano bubbles of molecular hydrogen are dissolved in the water, but do not actually bond with any of the H20 water molecules . another example are carbonated drinks  are enriched with CO2 (carbon dioxide gas) which gives these drinks their fizzy characteristic. 

So we have a gas made of 2 molecules of hydrogen in the water. Please note that alkaline ionize water also has more or less molecular hydrogen  H2 gas in it so Alkaline Ionized Water or Electrolysis Reduced Water is also Molecular Hydrogen Water

What is hydrogen gas?

Hydrogen gas is made up of two hydrogen atoms that are covalently bonded (2 atoms of hydrogen that share common electrons). This gas has a neutral charge and is the smallest and lightest gas in the universe. 6 These qualities make hydrogen gas extremely unique because it means molecular hydrogen  H2 can get anywhere it wants to in your body, including passing the blood-brain barrier, and into subcellular compartments such as the mitochondria of your cells. Molecular hydrogen is also known as a therapeutic medical gas with amazing medical potential in the scientific literature. 7

Is molecular hydrogen-rich water beneficial?

OF COURSE!!! Molecular hydrogen(water) has been demonstrated to be therapeutic in more than 600 scientific studies for more than 170 human disease models. 8 This means molecular hydrogen (water) has the therapeutic potential to help the vast majority of individuals today. Molecular hydrogen(water) has the potential to help the person dealing with seasonal allergies and to the person facing cancer. 9 Molecular hydrogen is one of the newest and simplest ways an individual can take preventative measures in their health.

Here are some examples of scientific studies refferring to molecular hydrogen) : In 1975, an impressive study demonstrated that hyperbaric molecular hydrogen therapy could be a possible treatment for cancer. In this study, the researchers showed that exposing mice with skin cancer (tumors) to 2.5 percent oxygen (O2) and 97.5 molecular hydrogen (H2) for two weeks produced a dramatic and significant regression of the mice tumors. Here is a quote from the study:

 “After a first 10-day period of exposure of the mice to the hydrogen-oxygen therapy it was found qualitatively (i) that the tumors had turned black, (ii) that some had dropped off, (iii) that some seemed to have shrunk at their base and to be in the process of being ‘pinched off,’ and (iv) that the mice appeared to suffer no deleterious consequences.” 5

In 2007 when a groundbreaking study demonstrated that molecular hydrogen is a selective antioxidant that neutralizes only the cytotoxic free radicals. The study was published in the prestigious Journal of Nature Medicine. 6 The study showed that molecular hydrogen neutralizes the hydroxyl radical (OH*), the most cytotoxic free radical in existence, one that the human body has no natural defenses against, and converts it into water.

Since 2007, medical research on molecular hydrogen has exploded proving this gas has remarkable medical potential.

Research studies and reviews about molecular hydrogen water

The evolution of molecular hydrogen (water): a noteworthy potential therapy with clinical significance

“Hydrogen has marked therapeutic potential to help with the top 8 fatality-causing diseases listed by the CDC.” 7

Molecular hydrogen: a therapeutic antioxidant and beyond

“Overall, the impact of molecular hydrogen in medicine is extraordinary. The non-toxic and rapid intracellular diffusion features of this biological gas ensure the feasibility and readiness for its clinical translation.” 8

Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications

“Recent publications revealed that, in addition to the direct neutralization of highly reactive oxidants, molecular hydrogen  H2 indirectly reduces oxidative stress by regulating the expression of various genes. Moreover, by regulating gene expression, molecular hydrogen H2 functions as an anti-inflammatory, antiallergic, and antiapoptotic molecule, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under way. Since most drugs act on their specific targets,molecular hydrogen H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, molecular hydrogen  H2 has potential for clinical applications for many diseases.” 9

Understanding the basic effects

Molecular hydrogen is a selective antioxidant 10

Molecular hydrogen appears to be a selective antioxidant. Molecular hydrogen appears to also reduce a powerful oxidant, Peroxynitrite (ONOO-). This would mean that Molecular Hydrogen has the potential to protect our DNA/RNA and proteins from damage (oxidative stress). Importantly, it does this while not perturbing cellular homeostasis;molecular hydrogen H2 does not neutralize beneficial free radicals (NO, H2O2, etc) necessary for the body to function properly.

Molecular hydrogen is a Nrf2 activator 11

Molecular hydrogen appears to stimulate the production of endogenous antioxidants via the Nrf2 Pathway, meaning it up-regulates the body’s own antioxidant system. This results in the production of more protective enzymes (antioxidants) such as glutathione, catalase, and superoxide dismutase. These antioxidants are powerful and aid in the reduction of excessive ROS and oxidative-stress within the body, which have been linked to nearly all human diseases.11.5

Molecular hydrogen is a signaling molecule/gene regulator 12

Molecular hydrogen appears to be a novel signaling molecule that participates in gene expression, cell modulation, and protein regulation. This means molecular hydrogen  H2 can alter cellular signaling pathways resulting in benefits far beyond its antioxidant function. Research has demonstrated that molecular hydrogen can regulate inflammatory cytokines, hormones, proteins, and much more.  Because of these properties, molecular hydrogen has the potential to give anti-inflammatory, anti-allergic, anti-cell death effects.

This is a short list of the potential therapeutic benefits for the human body that have been associated with molecular hydrogen  H2 research:

  • Selective antioxidant 10
  • Anti-Inflammatory Effects 11
  • Smallest, most bioavailable molecule 12
  • Aids in Gene Expression and regulation of proteins 13
  • Anti-Allergic Effects 14
  • Anti-Cellular Death (anti-apoptotic) 15
  • Increases Endogenous Antioxidants 16
  • Anti-Diabetic Effects 17
  • Anti-Cancer Effects 18
  • Improve Cognitive Function 19
  • Protects DNA & RNA 20
  • Anti-Tumor Effect 21

Based on scientific studies/evidence, molecular hydrogen gas ( water )therapy has the potential to benefit:

Alzheimer’s 37, arthritis 38, rheumatoid arthritis 39, Type 1 diabetes 40, Type 2 diabetes 41, Parkinson’s 42, COPD 43, asthma 44, heart disease 45, kidney disease 46, stroke 47, cancer 48, tumors 49, ALS 50, dementia 51, psoriasis 52, dermatitis 53, IBS 54, hemorrhagic shock 55, Crohn’s 56, fatty liver disease 57, liver cirrhosis 58, pancreatitis 59, cardiac arrest 60, neuropathy 61, Multiple Sclerosis 62, Hepatitis B 63, atherosclerosis 64, cataracts 65, hypertension 66, gum disease 67, traumatic brain injury 68, sepsis 69, subarachnoid hemorrhage (aneurysms) 70, infant lung disease 71, metabolic syndrome 72, lymphoma 73, retinitis 74, painful bladder syndrome 75, osteosclerosis 76, osteoarthritis 77, osteoporosis 78, glaucoma 79, pulmonary hypertension 80, pulmonary fibrosis 81, autism 82, depression 83, bipolar disorder 84, anxiety 85, schizophrenia 86, inflammation 87, muscle fatigue 88, increased ATP production 89, soft tissue injuries 90, pain 91, wounds 92, burns 93, seasonal allergies 94, autoimmune disorders 95, insulin resistance 96, hearing loss 97, ulcers 98, radiation damage 99, sleep apnea 100to name just a few as there are studies on over 170 human disease models

Who can drink molecular hydrogen water?

One of the best parts about molecular hydrogen water is that it has been shown to have a tremendous safety profile. This has been demonstrated in a few ways:

  • Out of 600-plus scientific studies, molecular hydrogen  H2 has shown no cytotoxic effects or cytotoxic by-products in the human body. 22
  • We have a basal level of molecular hydrogen  H2 in our blood stream at all times, around 1~5 micromolar or less. 23
  • Humans can produce up to 10 liters of molecular hydrogen  H2 a day with a good diet containing fruits, vegetables, and fiber-rich foods. This is due to the production of molecular hydrogen  H2 by our gut flora (gut bacteria). 24
  • Another reason we know molecular hydrogen H2 is safe is because it has been used to ameliorate decompression sickness in deep sea diving since 1945. 25 The molecular hydrogen H2 concentration has been as high 98.87 percent molecular hydrogen  H2 and 1.26 percent of O2, at 19.1 atm with minimal to no adverse or cytotoxic effects. 26 The United States military also has been using molecular hydrogen H2 for deep sea diving since the 60s. 27 Molecular hydrogen has been demonstrated to be extremely safe for the human body. 28

 

This information tells us that molecular hydrogen-rich water is safe for consumption in all age groups, from children to adults, as a preventive beverage that has the potential to reduce oxidative stress and so much more. Everyone, including children, is exposed to oxidative stress, which has been linked to the pathogenesis of nearly all disease conditions, including cancer. 29 Consuming water infused with molecular hydrogen is exactly what our society needs to aid in the battle against degenerative diseases.

Please note that most studies and research with molecular hydrogen gas were performed using molecular hydrogen rich water

 

To learn more about molecular hydrogen or hydrogen water’s potential health benefits and to see supporting scientific research visit: