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AlkaViva EmcoTech/Jupiter alkaline ionized water as cancer treatment -clinical case , integrative oncology

AlkaViva EmcoTech/Jupiter alkaline ionized water as cancer treatment -clinical case , integrative oncology

Abstract

The present article describes the ongoing (partial) remission of a female patient (41 years old) from estrogen receptor (ER)-positive/progesterone receptor (PR)-negative metastatic breast cancer in response to a combination treatment directed towards the revitalization of the mitochondrial respiratory chain (oxidative phosphorylation), the suppression of NF-kappaB as a factor triggering the inflammatory response, and chemotherapy with capecitabine. The reduction of tumor mass was evidenced by a continuing decline of CA15-3 and CEA tumor marker serum levels and 18FDG-PET-CT plus magnetic resonance (MR) imaging. It is concluded that such combination treatment might be a useful option for treating already formed metastases and for providing protection against the formation of metastases in ER positive breast cancer. The findings need to be corroborated by clinical trials. Whether similar results can be expected for other malignant tumor phenotypes relying on glycolysis as the main energy source remains to be elucidated.

1. Introduction

Since Richard Nixon declared war on cancer about 30 years ago, much efforts have been made in order to overcome this dreadful disease. Enormous financial resources have been invested in cancer research in the last three decades, yet most metastasized solid malignant tumors are still considered incurable. Chemotherapy has been shown to be a potent (long lasting) treatment option against only a few solid cancers including testis cancer. The overall contribution of curative and adjuvant cytotoxic chemotherapy was assessed to be 2.3% in Australia and 2.1% in the United States of America with a five-year survival in adults based on data for 1998 []. Under chemotherapy, cancer cells can gradually develop drug resistance that is acquired, for instance, by overexpression of transporter proteins (e.g., those belonging to the ATP-binding cassette type) [,] and fractionation of the cancerous stem cells [] (which are less sensitive to exposure to cytostatics than more differentiated cancer cells), plus AKT [,] and NF-kappaB [,] overexpression as a compensatory response to administered cytotoxic drugs. Likewise, induced hypoxia may act as protective shield against tumor eradication by chemotherapeutics and radiation due to alterations of gene expression profiles related to hypoxia, which result in the inhibition of apoptosis [].

On the other hand, a plethora of “alternative” cancer therapies have been developed and applied in the past. Here, we report on a combination treatment, including chemotherapy, bisphosphonates, and complementary measures, aiming at the normalization of the cellular metabolism, vascular angiogenesis, cell life cycle, and cell proliferation activity.

2. Experimental

2.1. Chemicals/Dietary Supplements

Super Ubiquinol CoQ10, Life Extension, article nr. 01426, USA: www.lefeurope.com

Vitamin B2, tablets, 10 mg, Jenapharm®, Mibe GmbH, Germany

Vitamin B3, capsules, 54 mg, Allpharm, Germany, PZN 6605862

5-Loxin®capsules, 75 mg, (std. for acetyl-11-keto-β-boswellic acid (AKBA), minimum 30% on dry basis), Life Extension, article nr. 00939, USA, www.lefeurope.com

Linseed oil, Linosan Leinöl, Heirler Cenovis GmbH, D-78303 Radolfzell, Germany

Bio-Kefir, Andechser Natur, 1,5% fat, containing L(+) dextrorotatory lactic acid, Andechser Molkerei Scheitz GmbH, D-82346 Andechs, Germany, www.andechser-molkerei.de

Bio-Yoghurt, Andechser Natur, 0,1% fat, containing L. acidophilus and B. bifidus, Andechser Molkerei Scheitz GmbH, D-82346 Andechs, Germany, www.andechser-molkerei.de

Flaxseed, freshly ground

EPA/DHA: Mega EPA/DHA, capsules, Life Extension, article nr. 00625

Sodium selenite, Selenase®200 XXL, 200 μg selenium, biosyn Arzneimittel GmbH, D-70734 Fellbach, Germany

L-Carnitine: Multinorm® L-Carnitin aktiv, 250 mg L-carnitin plus 3 μg Vitamin B12, Sankt Pirmin® Naturprodukte GmbH, D-55218 Ingelheim, Germany

L-Carnitine, 300 mg capsules: Altapharma, Germany

Zinc, Unizink® 50, 50 mg zinc-bis(hydrogen-DL-aspartat), Kohler Pharma GmbH, D-64665 Alsbach-Hähnlein, Germany, PZN-3441621

Ibandronat Bondronat®, 6 mg/6 mL concentrate, Roche Pharma AG, D-79639 Grenzach-Wyhlen, Germany

Capecitabine, Xeloda®, Roche Pharma AG, D-79639 Grenzach-Wyhlen, Germany

Drinking water ion exchanger and filter, pHresh, EMCO TECH Co. Ltd., Korea

Vitamin D and vitamin A were sporadically taken.

2.2. Procedure

The mentioned chemicals/dietary supplements have been taken as follows:

Alkalized drinking water was prepared ad lib by using water ion exchanger and filter. The filtered water was boiled prior to use.

Capecitabine was taken orally at 3.65 g Xeloda®/70 kg body weight per day. Two weeks of treatment were followed by one week of therapy pause per cycle.

“Budwig diet”: the following items were mixed for preparing a full batch using a blender: 1 kg Bio-Yoghurt, 0.1% fat, 0.25 kg Bio-Kefir, 1.5% fat, 6 table spoons of linseed oil, 4 table spoons of linseed, to be freshly milled: A part of this full batch may be prepared daily (the daily dose per person was about 250 grams).

Taken together around noon: 400 mg of Ubiquinol CoQ10 (4 capsules à 100 mg), 10 mg vitamin B2 (Riboflavin), 50 mg vitamin B3 (Niacin)

Taken three times daily: 2 softgels of MEGA EPA/DHA (eicosapentaenoic acid/docosahexaenoic acid), including 720 mg of EPA and 480 mg of DHA per 2 capsules.

One capsule of 5-Loxin®, one dose of Multinorm® L-Carnitin aktiv (taken only during chemotherapy pause; during the chemotherapy 300 mg pure L-carnitine not containing vitamin B12 was ingested), one tablet of Unizink® 50, and one tablet of Selenase®200 XXL were taken daily. EPA/DHA are COX-2 inhibitors. Therefore, the heart and vascular functions should be checked by a physician on a regular basis (it has been found that members of synthetic COX-2 inhibitors have been found to increase thrombosis, stroke, and heart attack risk under certain conditions). Moreover, Q10/B2/B3 were not taken in combination with radiation (the antioxidant Q10 potentially quenches the oxidative damage caused by radiation). EPA and DHA have potentially blood thinning effect.

3. Results

3.1. Applied Methodology and Methods

It has been hypothesized by the author that a multi-factorial approach towards breast cancer treatment would result in a synergetic response and reduced likelihood of development of resistance to treatment. Accordingly, it was sought to combine complementary, non-antagonistic treatments, which have the theoretical potential to suppress tumorigenesis and proliferation, with a “conventional” treatment. The envisaged therapy modules were Budwig diet and normalization of the fatty acid dietary balance, alkaline therapy, suppression of the inflammatory signaling chain, revitalization of the mitochondrial respiratory chain, bone protection against osteoclast-effected resorption by bisphosphonates and AKBA, and finally chemotherapy in the form of the prodrug capecitabine as 5-fluorouracil precursor []. The latter has been the recommended treatment by the medical tumor board in charge.

The described efforts have concretely been undertaken for suppressing refractory breast cancer stage IV in a female patient (body mass index 24–26, 41 years old), having developed a ductal carcinoma in situ in 2007. After biopsy revealed an estrogen receptor positive and progesterone receptor negative breast cancer, followed by surgical resection of the invaded sentinel lymph nodes, a neoadjuvant chemotherapy (four cycles Epirubicin/Cyclophosphamide, followed by four cycles of Taxotere®) was applied. However, the tumor showed little response (the tumor regression grade according to Sinn was only 1). Thus, the first and second axillary lymph node levels were resected in the following, and the affected breast was ablated. No suspicious tumor marker levels have been observed after ablation. The resection area was furthermore treated with radiation (gamma rays). The post-operational therapy included firstly tamoxifen, clodronate (a bisphosphonate), and a GNRH analogue (Enantone-Gyn®).

However, in September 2008, the patient – alerted by pain in the spinal cord – underwent MRI imaging, which revealed multiple bone metastases, including in the spinal cord.

As a consequence, the medication was altered as follows by the medical board in charge: Letrozol (aromatase inhibitor, 2.5 mg/d) and Ibandronat (6 mg intravenous infusion per month) as bisphosphonate. However, the disease progressed and a staging (18FDG-PET-CT and MRI) in March 2009 revealed the formation of various liver metastases. Therefore, the medication was changed to capecitabine chemotherapy instead of anti-hormonal therapy, accompanied by continuation of administration of Ibandronat.

Together with this therapy change, the author recommended the complimentary ingestion of the following substances: “Budwig diet” (linseed oil, flaxseed, and yoghurt), EPA/DHA concentrate in the form of distilled fish oil, ubiquinol (Q10 in reduced form), and vitamins B2 and B3, later on also 5-Loxin®(AKBA). See above for further dosage and substance specifications.

3.2. Results

After about three months (June 2009) of continued intake of the above mentioned substances (besides 5-Loxin®), PET-CT showed no metabolic activity of the liver metastases any longer and reduced activity of the bone metastases under 18F-deoxyglucose as tracer in the PET. Concurrently, a decline of the tumor markers’ (CA 15-3 and CEA) serum concentration was observed.

At this time, as a further element, 5-Loxin® (AKBA) was introduced into the supplementation scheme for the reasons mentioned.

Nine months later, the MRI showed that three out of six initial liver metastases could no longer be imaged, and that the largest lesion had decreased from about 15 mm to about 7 mm. A further small liver metastasis remained unchanged in size. This situation is depicted in Figure 1. Again, no metabolic activity in 18FDG-PET-CT was detected for any of the liver metastases.

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Diffusion-weighted MRI of the liver showing two metastases in the right lobe in (a) June 2009, and (b) February 2010. One metastasis (arrow) decreased from 15 mm in diameter to 7 mm, while the other remained unchanged (courtesy of Prof. Dr. E. Rummeny, Klinikum Rechts der Isar, Technische Universität München, Technical University of Munich, Germany).

Moreover, the PET-CT (18F-deoxyglucose as PET tracer) showed, in addition, a reduction of the size and metabolic activity of bone metastases, accompanied by re-calcification of the lesions. The response to treatment correlated with markedly decreased tumor marker serum levels, with CEA concentration being close to the significance threshold of 4 ng/mL. The development of the tumor marker levels over time is displayed in Table 1 below. The decline of tumor marker concentrations has been found to correlate with cancer remission in clinical studies on breast cancer patients [,]. In addition, the initial concentration of CEA has been associated with the clinical disease outcome in breast cancer patients.

Table 1.

Development of the CEA and CA 15-3 serum concentrations over time; cut-off values were 4 ng/mL for CEA and 27 U/mL for CA15-3.

Date/Months after Therapy Start CA 15-3 (U/mL) Excess over Cut-off Value [%] CEA (ng/mL) Excess over Cut-off Value [%]
29 June 2009/3 49.3 82.6 31.4 684
13 September 2009/7 46.2 71.1 8.4 110
11 January 2010/10 37 37.0 4.1 2.5
19 April 2010/13 38.3 41.9 3.6 -10.8
12 July 2010/16 35.7 32.3 4.1 1.5

The latest 18FDG-PET-CT of August 2010 showed ongoing sclerosis of at least some of the bone lesions and stable disease.

4. Discussion and Conclusions

A plethora of complementary cancer treatments have been reported. Firstly, the intake of polysaccharides and proteoglucans, such as mushroom and yeast glucans [  ,  ], mistletoe lectins [,] and nerium oleander extracts, the latter also in combination with sutherlandia frutescens extracts [,], have been described. The activation of the immune system against cancer cells has been ascribed to all of these compounds.

Another approach employed against the proliferation of cancer is alkaline therapy, which addresses the cellular acid-base balance. It has been found that extracellular/interstitial cancer tissue is more acidic than healthy tissue due to excessive production of lactic acid stemming from the glycolysis of glucose []. Otto Warburg already suggested in the last century that (as a consequence of hypoxia often encountered in tumor tissues) cancer cells undergo excessive glycolysis instead of relying on the energetically by far more effective oxidative phosphorylation [,], a fact which could recently also be verified by biopsy analysis in breast cancer patients, revealing a marked decrease in β-F1-ATPase/HSP60 expression ratio during disease progression []. Lately, it has been suggested that the initiation of glycolysis could be triggered by AKT activation during tumor development [] and that the resulting acidification of the extra-cellular cancer tissue brings about survival advantages for cancer cells [,]. It has been found recently that T-cell development is markedly suppressed in acidified cancer tissue []. Alternative alkaline therapies applied for cancer treatment included the intake of sodium bicarbonate [], cesium chloride [], or alkaline diet, which is based on fruit and vegetables having high potassium content. A further approach was the ingestion of alkaline drinking water obtained from ion exchangers.

Another avenue towards cancer suppression has been established by the supplementation of (essential) polyunsaturated fatty acids, aiming at re-establishing cellular membrane functionality [] and fluidity []. In addition, the polyunsaturated omega-3 fatty acids eicosapentaenoic (EPA) and docosapentaenoic acid (DHA) have been found to have a direct bearing on gene expression level by e.g., deactivation of NF-kappaB and AKT by EPA and DHA in a mouse model []. Polyunsaturated omega-3 fatty acids have also been shown to possess anti-inflammatory properties, for instance. by suppression of NF-KappaB and cyclooxygenases [], or caused by the reduction of prostaglandin E2 biosynthesis via arachidonic acid due to a shift in the omega-6 fatty acid/omega-3 FA level towards omega-3 species (omega-6 fatty acids form the pool for the endogenous biosynthesis of E2 prostaglandin) [,].

In addition, a direct positive correlation between cytotoxic drug efficacy and DHA level in breast adipose tissue of patients has been observed [  ]. Also, recent clinical studies suggested that EPA/DHA supplementation may suppress cancer-related cachexia []. Whereas severe side effects have been reported for the prolonged administration of some synthetic COX-II inhibitors, including increased thrombosis, stroke, and heart attack risk, to our best knowledge no comparably grave effects have been reported for the prolonged intake of EPA/DHA (e.g. in the form of fish oil) in clinical studies. The side effects of fish oil therapy, including blood thinning, have recently been discussed, e.g., by Farooqui et al.[].

Likewise, Johanna Budwig established a cancer diet (the so-called “Budwig diet”), which includes inter alia the daily intake of linseed oil as a potent source of alpha-linolenic acid as essential omega-3 fatty acid []. Anecdotal cases of complete cancer remissions after continued Budwig diet have been reported []. To our best knowledge, no randomized clinical trials exploring the efficacy of the Budwig diet have been launched to date. The consequence of a continued Budwig diet is said to be an optimization of the dietary balance of omega-6/omega-3 fatty acids and reconstitution of physiologically intact cellular membrane composition by enhanced administration of polyunsaturated fatty acids as a substitute for peroxidized and saturated fatty acids in cellular membranes, thus increasing membrane fluidity. Furthermore, it has been hypothesized that polyunsaturated fatty acids may act as oxygen carriers []. The present-day Western diet results in an adverse ratio of about 15:1 of omega-6/omega-3 fatty acids, whereas a ratio of about 1:1 has been reported as paleolithic reference value for humans []. As a consequence, the endogenous high level of omega-6 fatty acids in humans fosters the increased biosynthesis of pro-inflammatory arachidonic acid from e.g., linoleic acid. Moreover, it has been hypothesized that cottage cheese, quark or yoghurt as second constituent of the Budwig diet refills the pool of sulfhydryl amino acids (which are essential for glutathione biosynthesis).

Warburg considered the glycolytic switch as being a final event in cancer formation, accompanied by irreversible genetic changes and the inactivation of the mitochondrial respiratory chain in cells, giving rise to their dedifferentiation []. However, recent studies suggest that this may not be the case: Dichloroacetate has been shown to be a potent inhibitor of pyruvate dehydrogenase kinase, thereby suppressing, as other agents, the glycolytic switch and thus fostering oxidative phosphorylation [,,]. As a consequence of such an apparent normalization of the cellular energy production, cancer remissions in animal trials and anecdotal reports of healing of malignant tumors in human patients have been reported lately [].

Moreover, investigations involving the administration of coenzyme Q10 directed towards the revitalization of the mitochondrial respiratory chain suggest that, indeed, the inhibition of the respiratory chain (Q10 is present in various complexes thereof) can be reversed or at least be halted: Folkers et al. reported that breast cancer patients taking 90 mg per day Q10 stayed in a state of constant disease, and did not develop new metastases. No patient in the group died, although about 20% (6/32) deaths were statistically expected in the observation period. When the dose of Q10 was augmented to 390 mg daily, five patients who already showed remission under 90 mg of Q10 per day went into apparently complete remission, including the eradication of liver metastases [,]. Cases of complete remission in response to high doses of Q10 for other cancer types, such as small cell bronchogenic carcinoma, have also been published by Folkers et al.[].

Likewise, Sachdanandam et al. recently reported on tumor control and remission caused by a combination treatment by coenzyme Q10, vitamins B2 and B3 (all of which are essential for the cellular energy generation) and tamoxifen in animal trials []. As a result, markedly lower levels of lipid peroxidation and cachexia over the tumor-induced non-treated control group was observed. Orienting clinical trials of Premkumar et al., involving 84 breast cancer patients, affirmed the anti-tumor action of said agent combination []. Inter alia, a decrease of the plasma concentration of urokinase plasminogen activator (UPA) by about 50% was observed, and the level of adhesion factors such as E-selectin and pro-angiogenic proteinase MMP-9 were found to be drastically decreased after only 90 days of treatment. Moreover, significantly reduced tumor marker levels (CA-15-3 and CEA) have been measured after 90 days of coenzyme Q10, vitamins B2 and B3 plus tamoxifen combination treatment []. UPA expression level was determined as correlating with the clinical outcome of breast cancer, and UPA inhibition has therefore been made the target of extensive research [].

Another approach addressing the stabilization of the course of breast cancer is the administration of bisphosphonates [] such as ibandronate, which stabilize the bone matrix and thus impede osteoclast-mediated bone lysis. In addition, certain bisphosphonates, such as the latter compound, have been shown to possess direct anti-tumor action in vitro and in vivo [,].

Finally, a further route towards the suppression of cancers is the suppression of nuclear factor kappa B (a gene transcription promoter involved in the inflammatory chain and in a tumor’s capability to invade, metastasize and evade apoptosis) []. NF-kappaB stimulates the expression of various pro-inflammatory genes [,], also in breast cancer []. Consequently, a number of approaches have been divulged lately which are concerned with inhibition of this factor. The different compounds, which hinder the activation of NF-kappaB, are e.g., EPA (see above), and 11-keto-17-hydroxy boswellic acid (AKBA) [], a compound which has been shown to abrogate the osteoclastogenesis by inhibition of NF-kappaB activation in vitro. AKBA was also shown to hinder the enzyme 5-lipoxygenase [], which plays a pivotal role in the biosynthesis of pro-inflammatory leucotrienes. Remarkably, it has been shown that NF-kappaB inhibitors effectively inhibited MCF-7 breast cancer stem-like cells [].

In the present case, refractory breast cancer, which had not or has poorly responded to initial chemo- and anti-hormonal therapy, showed drastic and ongoing response to a combination treatment including capecitabine and complementary treatment components; the latter include NF-kappaB blockers, and other inhibitors of the inflammatory chain, respiratory chain stimulants, plus alkaline therapy. The rationale for employing these agents has been explained in the preceding paragraphs. No resistance to the therapy was observed after 17 months, and the decrease of tumor marker levels correlated with imaging results. The obtained results are significant in view of the initial heavy disease progress and lack of relevant response to all preceding therapies.

The incremental contributions of each individual treatment element remain unclear. However, it is hypothesized that a synergetic action of the measures takes place. These have been selected by theoretical considerations in order to avoid potential antagonistic interferences, which could annihilate action. It should also be noted that concerns about the simultaneous intake of chemotherapeutics and antioxidants have been raised in the literature, especially in the context of cytostatics that have free radical formation as their believed primary mechanism of action. To our best knowledge, the primary mechanism of action of capecitabine, however, is not via free radicals but DNA synthesis and thymidylate synthase inhibition []. No antagonistic interaction with the remaining measures “base therapy” (addressing the immune suppression observed in the acidic tumor environment due to the purported suppression of T-cell development in the acidic tissue adjacent to tumors) and bone stabilization by bisphosphonates has been expected. On the contrary, the reported suppression of NF-kappaB expression by e.g. AKBA should reduce the RANKL-induced osteoclastogenesis, which is triggered by the transcription factor NF-kappaB [].

Whether all measures contribute to the observed results remains speculative. The progression-free interval of 17 months observed so far is encouraging in view of a median time to progression from 3–9 months reported for the first line treatment of metastatic breast cancer by capecitabine []. Randomized clinical trials appear to be indicated in view of the promising orienting results.

Note that ER positive/PR negative breast cancer constitutes a rather limited high risk subset within the broader patient collective suffering from luminal breast cancer. Lately, it has been hypothesized in the literature that the expression of progesterone receptor (genes) in breast cancer has a positive bearing on the disease malignity and outcome, correlating with a less aggressive phenotype, and that the expression of progesterone receptor genes may be hindered by AP-1 [,,]. AP-1 and NF-kappaB have been shown to bind to UPA promoter sequence and to cooperatively foster UPA expression. Consequently, it has been directly or indirectly suggested to therapeutically inhibit NF-kappaB in order to improve efficacy of antiestrogen treatment of patients associated to high risk hormone-dependent breast cancer [,].

Moreover, the reduced UPA expression mediated by Q10 described in the literature could also be a sign of a reduced activity of the transcription factor AP-1. At the same time, reduction of AP-1 activity could lead to a reversal of the blockage of the progesterone receptor expression caused by the inhibitory action of AP-1 and a consequent sensitization of ER-positive/PR-negative breast cancers to anti-estrogenic treatment by tamoxifen (compare to references [,]).

It is further hypothesized that the obtained orienting results hint (as already observed for DCA) at a revitalization of the mitochondrial respiratory chain at the expense of a pathologic increase of glycolysis. The reduction of glucose metabolism of the metastases was corroborated by reduced signal intensity in 18FDG-PET-CT scans during the treatment. Hence, the results are interpreted as a pointer towards the (at least partial) reversibility of the glycolytic switch and the associated changes in gene profile expression.

 

SEE ALL WATER IONIZERS – MOLECULAR HYDROGEN GENERATORS

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Link to Publisher's site
. 2011 Mar; 3(1): 1454–1466.
Published online 2011 Mar 17. doi: 10.3390/cancers3011454
PMCID: PMC3756422
PMID: 24212668

Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Acknowledgements

Thanks are due to E. Rummeny and J. Gaa, both Department of Radiology, Klinikum Rechts der Isar, Technische Universitat Munchen, for kindly providing the MRI images and the image analysis.

Disclaimer

The author does not suggest that breast cancer can be healed by applying the described measures. Moreover, the author disclaims all responsibilities and liabilities as consequence of a potential application of the described treatment steps, either taken separately or in any combination by patients, third parties, institutions, or other persons, and for the correctness of the provided information. Questions concerning the disclosed treatment will be answered to physicians and clinical academia in general, only.

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37. Bonnet S., Archer S.L., Allalunis-Turner J., Haromy A., Beaulieu C., Thompson R., Lee C.T., Lopaschuk G.D., Puttagunta L., Harry G., Hashimoto K., Porter C.J., Andrade M.A., Thebaud B., Michelakis E.D. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007;11:37–51. [PubMed[]
38. Sun R.C., Fadia M., Dahlstrom J.E., Parish C.R., Board P.G., Blackburn A.C. Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res. Treat. 2010;120:253–260. [PubMed[]
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42. Lockwood K., Moesgaard S., Yamamoto T., Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem. Biophys. Res. Commun. 1995;212:172–177.[PubMed[]
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44. Perumal S.S., Shanti P., Sachdanandam P. Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria. Chem. Biol. Interact. 2005;152:49–58. [PubMed[]
45. Premkumar V.G., Vuvaraj S., Sathish S., Shanti P., Sachdanandam P. Anti-angiogenic potential of Coenzyme Q10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. Vascul. Pharmacol. 2008;48:191–201. [PubMed[]
46. Premkumar V.G., Yuvaraj S., Vijayasarathy K., Gangadaran S.G., Sachdanandam P. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Biol. Pharm. Bull. 2007;30:367–370. [PubMed[]
47. Muehlenweg B., Sperl S., Magdolen V., Schmitt M., Harbeck N. Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours. Expert Opin. Biol. Ther. 2001;1:683–691. [PubMed[]
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54. Zhou Y., Eppenberger-Castori S., Marx C., Yau C., Scott G.K., Eppenberger U., Benz C.C. Activation of nuclear factor-κB (NFκB) identifies a high-risk subset of hormone-dependent breast cancers. Int. J. Biochem. Cell Biol. 2005;37:1130–1144. [PubMed[]
55. Takada Y., Ichikawa H., Badmaev V., Aggarwal B.B. Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. J. Immunol. 2006;176:3127–3140. [PubMed[]
56. Safayhi H., Mack T., Sabieraj J., Anazodo M.I., Subramanian L.R., Ammon H.P. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Therap. 1992;261:1143–1146.[PubMed[]
57. Zhou J., Zhang H., Gu P., Bai J., Margolick J.B., Zhang Y. NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells. Breast Cancer Res. Treat. 2008;111:419–427.[PMC free article] [PubMed[]
58. Gelmon K., Chan A., Harbeck N. The Role of Capecitabine in First-Line Treatment for Patients with Metastatic Breast Cancer. Oncologist. 2006;11:42–51. [PubMed[]
59. Arpino G., Weiss H., Lee A.V., Schiff R., De Placido S, Osborne C.K., Elledge R.M. Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. J. Natl. Cancer Inst. 2005;97:1254–1261. [PubMed[]
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Articles from Cancers are provided here courtesy of Multidisciplinary Digital Publishing Institute (MDPI)

 

ionized alkaline water reduces HEMODIALYSIS-induced oxidative stress in END-STAGE RENAL DISEASE patients

 

Abstract

BACKGROUND:

Increased oxidative stress in end-stage renal disease (ESRD) patients may oxidize macromolecules and consequently lead to cardiovascular events during chronic hemodialysis. Electrolyzed reduced water (ERW) with reactive oxygen species (ROS) scavenging ability may have a potential effect on reduction of hemodialysis-induced oxidative stress in ESRD patients.

METHODS:

We developed a chemiluminescence emission spectrum and high-performance liquid chromatography analysis to assess the effect of ERW replacement on plasma ROS (H2O2 and HOCl) scavenging activity and oxidized lipid or protein production in ESRD patients undergoing hemodialysis. Oxidized markers, dityrosine, methylguanidine, and phosphatidylcholine hydroperoxide, and inflammatory markers, interleukin 6 (IL-6), and C-reactive protein (CRP) were determined.

RESULTS:

Although hemodialysis efficiently removes dityrosine and creatinine, hemodialysis increased oxidative stress, including phosphatidylcholine hydroperoxide, and methylguanidine. Hemodialysis reduced the plasma ROS scavenging activity, as shown by the augmented reference H2O2 and HOCl counts (Rh2o2 and Rhocl, respectively) and decreased antioxidative activity (expressed as total antioxidant status in this study). ERW administration diminished hemodialysis-enhanced Rh2o2 and Rhocl, minimized oxidized and inflammatory markers (CRP and IL-6), and partly restored total antioxidant status during 1-month treatment.

CONCLUSION:

This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress.

 2003 Aug;64(2):704-14.
Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

Author information

1
Department of Family Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis

BACKGROUND:

T-cell damage by increased oxidative stress in end-stage renal disease (ESRD) patients undergoing chronic haemodialysis (HD) led to the increased T-cell apoptosis and the alteration of surface markers and Th1/Th2 ratio in CD4(+) T lymphocytes. Antioxidant electrolysed-reduced water (ERW) /alkaline ionized water was used as the dialysate in end-stage renal disease  ESRD patients undergoing  chronic haemodialys HD to test for improved oxidative stress-related T-cell apoptosis, alterations of surface markers and intracellular cytokine profile.

METHODS:

We evaluated apoptosis formation by annexin V, CD25-related surface markers, and cytokine ratio of Th1/Th2 in CD4(+) T lymphocytes and Tc1/Tc2 in CD8(+) T lymphocytes of 42  end-stage renal disease ESRD patients haemodialysed with electrolysed reduced water /alkaline ionized water ERW for 1 year.

RESULTS:

In comparison to 12 healthy individuals, the  end-stage renal disease ESRD patients had more T-cell apoptosis and less CD3(+), CD4(+) and CD8(+) T cells and CD25/CD69/CD94/CD3(+) phenotypes at baseline. Lower intracellular IL-2 and IFN-gamma levels in the Th1/CD4(+) and Tc1/CD8(+) cells and higher intracellular IL-4, IL-6 and IL-10 levels in the Th2/CD4(+) and Tc2/CD8(+) cells were also noted in the  end-stage renal disease ESRD patients.

After a 1-year ERW/alkaline ionized water  treatment, the patients had a decrease in T-cell apoptosis and increases in CD3(+), CD4(+) and CD8(+) cell numbers and CD25/CD69/CD94/CD3(+) phenotypes in the T cells. The intracellular IL-2 and IFN-gamma levels in the Th1/Tc1 cells significantly (P < 0.05) increased and the intracellular IL-4, IL-6 and IL-10 levels in the Th2/Tc2 cells decreased. Furthermore, the Th1/Th2 and Tc1/Tc2 cytokine ratios were improved toward a normal status.

CONCLUSION:

One-year ERW /alkaline ionized water treatment effectively ameliorated T-cell apoptosis, altered CD25-related surface markers and intracellular cytokine profile in the haemodialysis HD patients.

PMID: 20190245
DOI: 10.1093/ndt/gfq082
 2010 Aug;25(8):2730-7. doi: 10.1093/ndt/gfq082. Epub 2010 Feb 26.
Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis.
1
Department of Family Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

Alkaline ionized water, OBLITERATING ARTERITIS and DIABETES 

Alkaline ionized water, obliterating arteritis and diabetes – ionized alkaline water saves from amputation one leg of the patient with obliterated arteritis and diabetes

“I write these lines both for my facebook friends and for the multitude of patients suffering from diabetes and implicitly by obliterant arteritis and who sooner or later reach stents mounted in coronary, iliac, subclavicular arteries, or worse -amputation of the lower limbs.
I retired in 2002 following a myocardial infarction and since then the troubles (medical problems) have kept coming.
Due to the insulin-induced diabetes diagnosed in the 1990s, between 2002-2005, three (2-foot) surgeries were done to replace the arteries (due to massive atheroma deposits) with femoral-popliteal vascular prostheses (by-passes) at the right foot twice.
In 2011, the right foot bypass began to close (by deposition of the atheroma), which made the stenosis of the arteries under the knee (tibial and peronian) almost reach 100%. Having had major coronary problems, the doctors refused to change my right foot bypass (it would have been the third time and recommended me to make a daily infusion of “vasaprosta”(  expensive and which was distributed by CNAS with special approval) for 30 days, the procedure being considered (then) as a means of rescuing the foot from amputation.
In my case this procedure (vasaphase infusions) proved to have the effect of rubbing with “Galenica” on an acacia wood leg. As the number of infusions increased, the pain of the foot soles was increasing and the leg was all the time cold.
I informed him several times of the doctor under whose supervision these perfusions were being made, of the evolution of the disease (unbearable pain and cold leg) but not only did he not count me but he did not even take a strain on my leg. For peace reasons I do not give  the name of the doc!
After 20 days of infusions, one morning after I woke up, I noticed that my toes were black and soaked. We had the gangrene.
I turned to emergency and the surgeon at the vascular surgery department (as a day of rest) refused to interfere because they did not cut off fingers and advised emergency staff to call the surgery department for leg amputation.
I went to Bucharest and admitted to the Emergency University Hospital at the Vascular Surgery Clinic.
On December 6, 2011 I my right leg fingers were amputated . Because the gangrene continued, on December 9 I underwent a new metatarsal amputation and replaced my vascular prosthesis with a saphenous vein harvested from the amputee foot
On December 12, I had a heart attack and I was admitted to intensive care. On December 15 we made a cardiac arrest and I was intubated …
I stayed intubated for several days in incapacity, while my lungs were sucked several times a day.
After I was discharged from intensive care, I was admitted to cardiology and after a while I began to cough more and more. I was treated with bronchitis until discharge from the hospital
The cough continued after discharge and eventually I went to emergency in Constanta at the Otolaryngology section, where it was ascertained that due to intensive care suction maneuvers, after the cardiac arrest, my trachea was injured, which led to the appearance of an excrescence that finally almost obstructed my trachea.
I had surgery (post-tubal tracheostomy) and through surgery I was mounted a plastic cannula under the apple of Adam through which we breathe.
The operation of the foot has never healed.
In June 2013, I was implanted (I do not know if the term is correct) 5 stents in the coronary hearts at Fundeni Hospital.
In September 2013 (year with bad luck) the foot pain again began to amputate, having to accept a new amputation this time above the knee.
Finally, in September, three successive amputations were made at my right foot by a “great” doctor professor, but more about the professionalism and competence of the individual maybe another time.
After the third amputation, I went home with half the stools from the bumps and with my leg in the amputation area. After another month of home treatment, a nurse in surgery managed to heal my dent.
Since spring last year, my left foot, which has a femur-popliteal prosthesis since 2004 (they are guaranteed for 5-6 years) has started to hurt and the situation worsens in the beginning of 2017, with all medications, ointments and massages (including lymphatic) that have been given and done all along.
In February 2017, I did a vascular / arterial doppler exam that revealed that the bypass has a 70% stenosis, the anterior tibial is oval, the posterior tibial has 98% occlusion, and the peroneal artery has a 98% occlusion. Finally, the cardiologist who did my doppler exam, probably to encourage me,  said that in 2-3 weeks I will get to left foot amputation and showed me where they were going to amputate ….

I have a good friend and colleague from high school class, the energetic engineer GIDEA- SANDUTU VERGICA from Filiasi whom I told of my misfortune and that soon I will lose my left leg through amputation

Very relaxed and with great confidence he told me that I do not have to worry -they will not amputate my leg as he’ll help solve my problem. I replied that it was not good a joke … not to say anything else. He explained that there was no joke, that he would not allow himself to make jokes with me in the given situation and asked me if I heard anything about ALKALINE IONIZED WATER. NO, I said. I said that I do not know what it is, and that I do not think there is any drug in the world (which we also know, foolishness) that can dissolve the arteries deposits … much less a water,she would call it she-chiara, holy water or ionized alkaline water. Having realized he had no palpable arguments to convince me, he told me that this water produces absolutely nothing wrong with the body when drinking it and that he will send me water starting from the next day, having previously bought a water ionizer for producing this ionized alkaline water;he also told me that in my situation, I have two possibilities, namely:

– first, to expect the blood circulation to the leg to close definitively and reach to the gangrene and amputation,

-second  to drink at least 5 liters of ionized alkaline water daily, the water that will melt the atheroma from the arteries, the circulation of the blood going back to normal and save my foot.

I chose the second variant, knowing it was terrible it’s hard to live without a foot and get you I do not think it’s worth the pain anyway, I think it would not be worth the trouble for those around you, I would have become a calvary (I do not know if I’m wrong about that) I began to drink ionized alkaline water, sent by my friend, in the first few days 3 liters after which, I easily drank 5-6 liters a day. By then, the foot was from the kneel down, cold and white, and pains and burns, especially at night, were unbearable; I got 3-4 ketone pills per night. After 2 weeks of drinking ionized alkaline water the pains and burns diminished and in a few days they finally disappeared. 3 weeks ago his leg warmed and so remained. On March 17 we went to a private clinic in Constanta and I did (against the sum of 800 lei, CNAS funds not yet allocated) an angio CT scan of the arteries of in the pelvis and lower limbs that revealed:

– thigh amputation its right;

– 50% bypass stenosis

– 70% tibio-peronian occlusion trunk

– posterior tibial artery

– occlusion

In the meantime I was scheduled to be admitted to the Emergency University Hospital of Bucharest and on May 12, 2017, I made an arteriography revealed that the aorta and the iliac shaft are permeable, the femoropoplite bypass is permeable and permeable gambling trunk. Arteriography is an invasive artery investigation and remains the most significant in analyzing blood circulation, measurements and images being made from within the arteries.

I will express in words what I felt when the doctor who made the investigation recorded her voice with the result of viewing the monitor on which the arteriography was displayed. Never before, in my life, a word so common as  “PERMEABLE” had such GREAT significance and value.

I think the sun has appeared on my street, which is what I want. If you want to document and see that ionized alkaline water seems to be the universal medicine, you can find hundreds of sites about it and its benefits. In the meantime I bought a  ALKAVIVA water ionizer  !

I wish only good things!

.PS I WILL TALK AND ABOUT THE DIABETES SPPN …A FEW MONTHS AGO I HAD 40 MIXTARD UNITS IN THE MORNING AND 20 AT NIGHT

NOW- 20 UNITS IN THE MORNING AND 10 IN THE EVENING …

TODAY THE GLICEMIC INDEX IN THE MORNING WAS 124 AND I DID NOT HAVE ANY MIXTARD .NOW I HAVE GLYCEMIA 70 AND I HAVE NO NEED FOR MIXTARD ”

DESPRE APA ALCALINA IONIZATA Scriu aceste randuri atat pentru prietenii mei de pe…

Publicată de Alexandru Bîzdîc pe Duminică, 18 iunie 2017

MORE ABOUT ALKALINE IONIZED WATER/  molecular hydrogen H2- Water  AND DIABETES

MORE ABOUT ALKALINE IONIZED WATER/ molecular hydrogen H2- Water  AND BLOOD VESSELS HEALTH

 

 

AlkaViva UltraWater filtration technology

AlkaViva UltraWater filtration technology 

 

Simply put, AlkaViva UltraWater filtration is the best alkaline water ionizer filter you can buy. In fact, it is the best water filter — of any type — that is currently available. Our unmatched Independent EPA / NELAP certified lab tests prove it. We often get asked how we can achieve such stunning water filtration/contaminant removal results.
ultrawater water ionizer filtersSmart Shopper’s Shortcut 
What you need to know about UltraWater filtration…AlkaViva UltraWater Filtration TechnologyWhat good is healthy water if it isn’t also clean water? Better than 0.01 micron UltraFiltration or a series of external water filters, UltraWater incorporates  Sediment shield, BioStone Booster, BioStone Carbon Block with Impregnation Plus(zeolite and silver), Bioceramic Tourmaline with Scale Guard, UltraWater Disc Technology to offer ultraclean alkaline ionized and molecular hydrogen water and most important has been tested and certified by a governmental laboratory for efficient removal of 172 water contaminants  – UltraWater filtration technology – the most thoroughly tested and safest water filtration option available.

Here’s How We Do It

Let’s start with an analogy: turbocharged gas engines. When they first came out, they combined new and existing technologies in a novel way. The result was a powerful new combination and unprecedented performance. Similarly, UltraWater filtration technology starts with the water industry’s proven top-performing media, adds in cutting edge medias in a new application, and then creates a new twist on existing manufacturing techniques. The result isn’t just a water filter. It’s a proprietary water filtration technology. This unique combination effectively “turbocharges” the media and water filtration processes, allowing better water filtration performance and better results.

What’s Inside:

sediment shield ultrawater filter

Sediment Shield

Standard GAC water filters do not offer this component. It is an electrostatic wrap comprised of polypropylene spun fiber. It is designed to provide a mechanical barrier to sediment – meaning it traps the sediments.

biostone booster ultrawater filter

Biostone Booster

Comprised of NSF certified CaSO3 slow-eluting bio-ceramic balls. They target chlorine, chloramine certain heavy metals. CaSO3 is more effective than granulated active carbon or KDF. One hundred grams (100g) of CaSO3 will outperform carbon and KDF by a factor of x2.

biostone carbon plus media

BioStone Carbon with Impregnation Plus

Our NSF certified carbon is catalyzed with an oxidizer and has the highest oxidation and adsorption pore concentration available. The carbon is impregnated with natural zeolite(vulcanic rock) and silver(antimicrobial).

The zeolite provides increased heavy metal reduction and a slight ion-exchange effect.

The silver prevents bacteria growth between uses.

We use both carbon block and loose bed applications.

Our carbon blocks are sintered and compressed under high temperature and heat (not extruded) resulting in a superior carbon block. Either way, our proprietary process greatly increases the surface area, contact time and the resulting capability.

ultrawater disc technology in filter

UltraWater Disc Technology

This leading-edge technology is the real turbocharger in UltraWater filter. It combines a high-tech NSF certified reticulated foam which is impregnated with three different medias. All are NSF certified. All offer unmatched heavy metal and organics reduction allowing us to target contaminants that other alkaline water ionizer filters can’t – such as arsenic.

bioceramic tourmaline

Bioceramic Tourmaline with Scale Guard

The tourmaline is in a very hard, slow-eluting biocermic ball from. It releases FAR infrared energy lowering surface tension. Scale Guard is a sequestering agent that is a highly effective anti-scale media. It is in a slow-eluting crystal bead form and is there to protect the water ionizer from hard water damage.

What it Does

UltraWater is the ONLY alkaline water ionizer filter tested for 172 contaminants. Independent EPA / NELAP certified lab testing shows UltraWater is the ONLY water filter that can reduce virtually all contaminants up to 99.9% — even the toughest including arsenic, chromium VI, lead, VOCs and pharmaceuticals

UltraWater filtration technology selectively reduces the bad contaminants while allowing the good, naturally occurring minerals to pass through. This alkaline water ionizer filter design is used in AlkaViva’s UltraWater electric water ionizer range to produce electric ionization.

UltraWater filtration  can also be formulated to create natural water ionization without electricity. Some of the world’s renowned sources of healing water are passively ionized by contact with certain earth alkali minerals, silicate and crystalline complexes. We have formulated an exclusive “passive water ionization” technology inside our non-electric Elita Series which contains the same type of mineral complexes. As water passes over the passive water ionization media we create increased pH, –ORP and molecular hydrogen (H2 water). While multiple beneficial minerals are dissolved, it chiefly infuses magnesium, which is shown to be absorbed best by the body when dissolved in water.

So regardless of which AlkaViva water product you choose, ultraclean and effective UltraWater is the best answer!

Available exclusively from:

ultrawater water ionizer filters

UltraWater Water Ionizer Filters – Tested for 172 Contaminants

Better water filtration Performance. Safer Water. Better Health.

Healthy water has to be clean water. Other ionizer filters simply cannot handle well known water contaminants such as lead, arsenic, chromium VI – and a host of others. Independent EPA / NELAP certified lab testing shows UltraWater reduces virtually all contaminants up to 99.9% — even the toughest including arsenic, chromium VI, lead, VOCs and pharmaceuticals.

AlkaViva testing is:

 

  • Certified & credible: All tests performed in Independent, EPA / NELAP Certified Labs
  • Thorough: we omit nothing and we show results for everything tested.
  • Real world: we tested contaminant levels in parts per million and that were as close the EPA Maximum Contaminant Level as we could get .
  • Nothing hidden or left out: we reported everything – even the toughest to remove contaminants such as arsenic, chromium VI etc.
  • Comprehensive: We tested 21 heavy metals, 65 pharmaceuticals, 3 OTC drugs, 7 Hormones, 15 pesticides and herbicides, preservatives and wastewater indicators, 45 VOCs, and 5 other anions & disinfectants – a total of 172 contaminants!
  • 16 Supercharged Medias
    Advanced Filtration Technologies.
    >See Test Results

AlkaViva UltraWater Filter Removes

lead in waterLead
arsenic in waterArsenic
drugs in waterPrescription Drugs
chemicals in waterIndustrial Chemicals
hormones in waterHormones
chlorine in waterChloramine
chemical waterTrihalomethane
preservatives in waterPreservatives
herbicides in waterHerbicides
volatile chemicals in waterVolatile Organic Compounds
Chromium VI in waterChromium VI
chlorinated waterChlorine
polluted waterOTC Drugs
pesticides in waterPesticides
heavy metals in waterHeavy Metals

You NEED AlkaViva UltraWater Filtration

AlkaViva free local water report

 

 

 

alkaline ionized water/hydrogen rich water and LONGEVITY

Abstract

The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model. Starting from the second year of life, nonparametric survival plots suggest that mice watered with alkaline ionized water showed a better survival than control mice. Interestingly, statistical analysis revealed that alkaline ionized water provides higher longevity in terms of “deceleration aging factor” as it increases the survival functions when compared with control group; namely, animals belonging to the population treated with alkaline ionized water resulted in a longer lifespan. Histological examination of mice kidneys, intestine, heart, liver, and brain revealed that no significant differences emerged among the three groups indicating that no specific pathology resulted correlated with the consumption of alkaline ionized water. These results provide an informative and quantitative summary of survival data as a function of watering with alkaline ionized water of long-lived mouse models.

1. Introduction

Alkaline water, often referred to as alkaline ionized water (AKW), is commercially available and is mainly proposed for electrolyte supplementation during intensive perspiration. Early studies on animal models reported that alkaline ionized water supplementation may exert positive effects on body weight improvement and development in offspring []. Even biochemical markers were analyzed, suggesting that alkaline ionized water intake can cause elevation of metabolic activity. In particular, hyperkaliemia was observed in 15-week-old rats and pathological changes of necrosis in myocardial muscle were found [].

More recently, studies were carried out on alkaline ionized/electrolysis reduced water (ARW), referring to electrolyzed water produced from minerals, such as magnesium and calcium, which is characterized by supersaturated hydrogen, high pH, and a negative redox potential ORP. This hydrogen-rich functional water has been introduced as a therapeutic strategy for health promotion and disease prevention [].

Alkaline ionized/ electrolyzed reduced water have been shown to exert a suppressive effect on free radical levels in living organisms, thereby resulting in disease prevention []. Various biological effects, such as antidiabetic and antioxidant actions [], DNA protecting effects [], and growth-stimulation activities [], were documented.

Although a variety of bioactive functions have been reported, the effect of alkaline water on lifespan and longevity in vivo is still unknown. Animal alkalization has been shown to be well tolerated and to increase tumor response to metronomic chemotherapy as well the quality of life in pets with advanced cancer []. Therefore, we performed a study based on survival rate experiments, which play central role in aging research and are generally performed to evaluate whether specific interventions may alter the aging process and lifespan in animal models.

2. Materials and Methods

Biological effects of alkaline ionized water were evaluated on a selected population of 150 mice (CD1, by Charles River, Oxford, UK). Pathogen-free mice were purchased and placed in a specific breeding facility. No other animal was present in the room. Contact with animal caretakers was minimized to feeding and watering. The population was divided into 3 groups, each consisting of 50 individuals, as follows:

  1. Group A: 50 mice conventionally fed and watered with alkaline ionizefd water produced by the Water Ionizer (mod. NT010) by Asiagem (Italy). The Water Ionizer is a home treatment device for producing alkaline drinking water.
  2. Group B: 50 mice conventionally fed and watered with alkalized water obtained by dilution of a concentrated alkaline solution (AlkaWater by Asiagem, Italy). AlkaWater is a concentrated alkaline solution for preparing alkaline drinking water.
  3. Group C: 50 mice conventionally fed and watered as conventional (control group) with tap water. The local water supply was evaluated weekly for assuring the absence of toxins and pathogens. The pH values were in the 6.0–6.5 range.

All procedures involving animals were conducted in accordance with the Italian law on experimental animals and were approved by the Ethical Committee for Animal Experiments of the University of Padua and the Italian health Ministry (Aut. no. 39ter/2011). Efforts were made to minimize animal suffering.

2.1. Histological Examination

Treated aged mice were sampled postmortem and subjected to histological examination. Animals belonging to the populations treated with alkaline water, A and B, were sacrificed after 24 months and compared to mice treated with tap water. Samples from kidneys, intestine, heart, liver, and brain were fixed in 10% neutral buffered formalin, and 4 μm sections were analyzed by optical microscopy.

2.2. Statistical Analysis

In order to investigate the biological influence of alkaline water on mouse longevity, we employed the accelerated failure time model (AFT) [], which allows formally exploring the possible effect on survival curves of the applied three-level treatment, that is, examining the role of group membership as a covariate of lifespan. As a more robust alternative to the commonly used proportional hazards models, such as the Cox model, the use of AFT models is advised in the field of survival analysis when the goal is to investigate if a covariate may affect the lifespan in a way that the life cycle may pass more or less rapidly. In fact, whereas a proportional hazard model assumes that the effect of a covariate is constant over time, an AFT model assumes that the effect of a covariate is to accelerate or decelerate the life course.

The relevance of AFT model for biomedical studies has been already recognized in the literature []. With more specific reference to the issue of aging, Swindell [] observed that some genetic manipulations were found to have a multiplicative effect on survivorship which were well characterized by the AFT model “deceleration factor.” Moreover, Swindell [] argued also that the AFT model should be utilized more widely in aging research since it provides useful tools to maximize the insight obtained from experimental studies of mouse survivorship.

To perform all calculations, we applied a parametric survival analysis approach using a class of 3-parameter AFT distribution models implemented within the statistical software Minitab, version 17.2.1 []. More specifically, we employed three types of random distributions, namely, log-logistic, log-normal, and generalized Weibull.

3. Results

The experiment consisted in an initial 15-day acclimatization period. After acclimatization, animals (50, group A) were watered with alkaline ionized  water (pH 8.5), obtained by the Water Ionizer ,  whereas group B animals (50) were watered with water alkalized at pH 8.5 by a concentrated alkaline solution  for 15 days. Group C animals (50), control group, were watered with the local water supply. This period has been identified to gradually accustom the animals treated with alkaline water. At the end of the second period of acclimatization, group A and B animals were watered with alkaline ionized water at pH 9.5, while animals of group C were watered with local tap water.

After the first year, the most aggressive individuals were moved to other cages within the same group and an environmental enrichment protocol was employed in order to decrease the hyperactivity. This phenomenon was observed especially in animals of groups A and B.

Table 1 reported basic statistics on mice survival of treated and control animals.

Table 1

Basic statistics on mice survival by treatment level.

Treatment level Mortality rate
%
Lifespan mean (std. dev.)
Days
Group A 88 679 (209)
Group B 92 671 (180)
Group C 96 667 (185)

Regarding group A, animals (50) were watered with alkaline ionized water (pH 8.5), obtained by the Water Ionizer (Asiagem, Italy). As for group B, animals (50) were watered with water alkalized at pH 8.5 by a concentrated alkaline solution for 15 days. Regarding group C, animals (50), control group, were watered with the local water supply.

A first look on experimental data is provided in Figure 1, where nonparametric hazard and survival plots seem to suggest that even if no macroscopic difference emerges, starting from the second year of life mice watered with alkaline ionized  Water  and those treated with AlkaWater overwhelmed control mice.

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Nonparametric hazard and survival plots by treatment level. Group A: animals (50) were watered with alkaline ionized water (pH 8.5), obtained by the Water Ionizer  Group B: animals (50) were watered with water alkalized at pH 8.5 by a concentrated alkaline solution  for 15 days. Group C: animals (50), control group, were watered with the local water supply.

In order to explore the possible effect of different treatments, that is, to examine the role of group membership on longevity, we applied a parametric survival analysis approach using a class of 3-parameter survival distributions that represent flexible accelerated failure time, AFT models. First of all, using the Anderson-Darling goodness-of-fit statistic, we compared three specific survival distributions, that is, log-logistic (AD = 6.397), log-normal (AD = 6.519), and generalized Weibull (AD = 6.447). Since the best fitting was shown by log-logistic model, we adopted this one as final survival distribution model. The straight lines in the log-logistic distribution QQ plots (Figures 2(a) and 2(b)) indicate that this distribution provides a suitable fit to our survival data.

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QQ plots using the 3-parameter log-logistic distribution model. (a) Treatment A survival time quantiles (vertical axis) versus treatment C survival time quantiles (horizontal axis); (b) treatment B survival time quantiles (vertical axis) versus treatment C survival time quantiles (horizontal axis).

Finally, by including our treatment as covariate, we performed a parametric distribution analysis whose results are graphically represented in Figure 3.

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Distribution plot results using the 3-parameter log-logistic model. Group A: animals (50) were watered with alkaline ionized water (pH 8.5), obtained by the Water Ionizer . Group B: animals (50) were watered with water alkalized at pH 8.5 by a concentrated alkaline solution for 15 days. Group C: animals (50), control group, were watered with the local water supply.

Starting with the second year of life, it is worth noting that both alkaline water treated groups denote a decreasing hazard curve over time, while the corresponding curve for control group is monotonically increasing. To more formally compare the treatment levels, the proposed analysis provided also suitable pvalues. Since the p values related on the null hypotheses of equality of location, scale and threshold parameters were, respectively, less than 0.001 (for both locations and scales) and 0.634 (for thresholds) at a 5% significance level; we can state that there is enough experimental evidence to conclude that the treatment significantly affects the mice longevity; in particular the alkaline ionized water provides a benefit to longevity in terms of “deceleration aging factor” as it decreases the hazard functions when compared with the control group. Note that the treatment effect cannot be directly related to no one of the three distribution parameters. Anyway, using the estimated parameters, it should be possible to provide an estimate for the effect of each treatment on survivorship: setting the reference survival time to 1000, 1200, and 1400 days, Table 2 summarizes the estimated point and 95% interval survival probabilities by each treatment level.

Table 2

Table of survival probabilities by treatment level. The probabilities, along with their related 95% confidence interval limits, were calculated using the normal approximation.

Treatment level Time (days) Estimated probability Lower 95% CI limit Upper 95% CI limit
A 1000 0.116 0.056 0.226
1200 0.046 0.014 0.140
1400 0.020 0.004 0.098

B 1000 0.055 0.021 0.137
1200 0.013 0.003 0.066
1400 0.004 0.000 0.039

C 1000 0.049 0.022 0.106
1200 0.008 0.002 0.027
1400 0.001 0.000 0.007

As final remark, it should be noted that even if our parametric AFT survival analysis was performed using the log-logistic distribution, our conclusions are consistent with results obtained using the generalized Weibull distribution, while via log-normal distribution no significant effect was found.

3.1. Histological Examination

No significant differences emerged from the histological examination among the three groups. In all examined samples, renal tissue was characterized by a mild-to-moderate lymphoplasmacytic interstitial infiltrate and few occasional glomerular changes as glomerular size reduction and increasing of Bowman’s space (Figure 4).

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Kidney, a specific chronic nephropathy. Focal interstitial mainly lymphocytic infiltrate (upright) and a sclerotic glomerulus (middle right). Hematoxylin and Eosin.

Final diagnosis was mild chronic progressive nephropathy for the three analyzed mouse groups.

The microscopic examination of the liver revealed a multifocal nodular pattern of the parenchyma and diffuse mild-to-moderate hepatocellular cytoplasmic hydropic degeneration with multifocal binucleation in all explored animals (Figure 5).

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Liver, aging change. Hepatocellular abundant dishomogeneous cytoplasm, binucleation (center), variably sized nuclei, and a nuclear pseudoinclusion cyst (arrow). Hematoxylin and Eosin.

Mild-to-moderate anisokaryosis was the most relevant alteration, with few pleomorphic nuclei and frequent intranuclear pseudoinclusions and karyomegaly. A specific mild perivascular infiltrate was occasionally present. Final diagnosis was mild-to-moderate diffuse hepatopathy with multifocal hyperplastic hyperplasia.

The pulmonary parenchyma showed mild multifocal areas of interstitial thickening of the interalveolar septa due to moderate congestion and mild cellular mixed infiltrate (Figure 6). Mild areas of emphysema were detected at the periphery of the parenchyma. Final diagnosis was multifocal very mild atelectasis and mild vicarious emphysema.

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Lung, mild atelectasis. Very mild multifocal interstitial thickening of the alveolar septa associated with congestion and mild cellular increase. Hematoxylin and Eosin.

At the same time, no relevant histopathologic histological changes have been noticed in intestine (Figure 7), brain, and heart.

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Intestine. Longitudinal section of duodenum showing uniformly thin and elongated villi. Hematoxylin and Eosin.

4. Discussion

The present work presents a 3-year survival study on a population of 150 mice and the data were analyzed with accelerated failure time (AFT) model. Kaplan-Meier statistical analysis of the survival data indicates the possibility of a positive effect of alkaline ionized water on mouse lifespan and AFT model allowed evaluating differences starting from the second year of the survival curves. These results provide an informative and quantitative summary of survival data as a function of watering with alkaline ionized water on long-lived mouse models. It should be pointed out that, from the standpoint of aging research, this statistical approach presents appealing properties and provides valuable tools for the analysis of survival. The observation of tissues of deceased animals was performed for the assessment of the state of internal organs to be compared with similar analyses of untreated animals. The renal lesions observed at histology were specific and common for the three animal groups. Chronic progressive nephropathy has been well described as normal aging change in mice []. In our cases animals did not show any clinical sign of nephropathy or any other histological evidence of specific kidney disease and we ascribed the lesions to the aging process [].

The examined livers were also affected by typical lesions of mature subjects, such as hyperplastic nodules. Furthermore, well known aging changes were individuated in the hepatocytes, such as karyomegaly, nuclear pleomorphism, and pseudoinclusions cysts [].

5. Conclusions

A 3-year survival study on a population of 150 mice was carried out in order to investigate the biological effect of alkaline water consumption. Firstly, nonparametric hazard and survival plots suggest that mice watered with alkaline ionized water overwhelmed control mice. Secondly, data were analyzed with accelerated failure time (AFT) model inferring that a benefit on longevity, in terms of “deceleration aging factor,” was correlated with the consumption of alkaline ionized water. Finally, histological examination of mice kidneys, intestines, hearts, livers, and brains was performed in order to verify the risk of diseases correlated to alkaline watering. No significant damage, but aging changes, emerged; organs of alkaline watered animals resulted to be quite superimposable to controls, shedding a further light in the debate on alkaline water consumption in humans.

Acknowledgments

This paper is dedicated to the memory of Tommaso Nicoletti. The authors are grateful to Rocco Palmisano for original ideas and support. The authors would like to thank Asiagem (Italy) for partial support and Ludovico Scenna, Carlo Zatti, and Silvano Voltan for their scientific and professional contribution.

Competing Interests

The authors declare that there are no competing financial interests.

Published online 2016 May 31. doi: 10.1155/2016/3084126
PMCID: PMC4906185
PMID: 27340414
Alkaline Water and Longevity: A Murine Study

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Articles from Evidence-based Complementary and Alternative Medicine : eCAM are provided here courtesy of Hindawi Limited

Daily ingestion of alkaline electrolyzed water containing hydrogen influences HUMAN HEALTH, including GASTROINTESTINAL symptoms

Abstract

In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefinite complaint. The object of this study is to evaluate the effect on health, including gastrointestinal symptoms, when a person without abdominal indefinite complaint, etc., drinks AEW on a daily basis. A double-blind, randomized controlled trial has been designed. Four-week period of everyday water drinking, PW drinking group: drink purified tap water as a placebo, AEW drinking group: drink alkaline electrolyzed water which made by electrolysis of purified tap water. Before the experiment and after the 4-week period of water drinking, Blood tests, physical fitness evaluations, and questionnaire evaluations is conducted. In this study, we did not specifically select patients with gastrointestinal symptoms. Sufficiently clear effect could not be confirmed. But the stools were more normal, and, as shown in the previous report, that drinking AEW is considered to contribute to intestinal normalization. In addition, when drinking AEW, a high proportion of the respondents said that they felt they were able to sleep soundly, and the proportion of subjects who answered that they felt good when awakening increased. The effect of reducing oxidative stress, thus allowing for improved sleep, was exhibited by drinking AEW containing hydrogen, which is considered to be an antioxidant substance. This research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018.

Keywords: alkaline electrolyzed water, gastrointestinal symptoms, hydrogen-dissolved water, physical fitness evaluations, questionnaire evaluations, functional beverage

Introduction

In Japan, water which is obtained on the cathode side by the electrolysis of tap water is called alkaline electrolyzed water (AEW) or reduced hydrogen water. Improvement of gastrointestinal symptoms by ingesting AEW has been confirmed by Japanese researchers. For example, Naito et al. reported the inhibitory effect of AEW ingestion on gastric mucosal disorder caused by aspirin, and Hayakawa et al.reported the inhibitory effect of AEW ingestion on abnormal intestinal fermentation. Tashiro et al.examined the effect of ingesting AEW or purified tap water (PW; as a placebo) at a rate of at 500 mL per day for 4 weeks in patients who had abdominal pain such as heartburn, stomach discomfort, abdominal bloating, diarrhea, constipation, etc., and reported that the results of the AEW group were superior to those of the placebo group., From these results, apparatus that produce AEW have been approved as medical devices by the Japanese Ministry of Health, Labour and Welfare. AEW is thought to be effective for functional gastrointestinal disorders.

Since AEW is produced by electrolyzing water, hydroxide ions, which are alkaline in nature, are generated. Hydrogen molecules are also generated on the electrode surface and dissolved in water. Therefore, AEW is alkaline water containing hydrogen. In conventional efficacy studies, evaluations with respect to ingesting AEW have typically been conducted focusing on the alkalinity of the water.,,, In recent years, however, the assumed effectiveness of the antioxidant effect of dissolved hydrogen on various diseases has been reported.,,,,,,,, Nevertheless, some users of AEW apparatus do not have any definite abdominal symptoms. In many cases, they are drinking AEW on a daily basis to improve their health, and many users also feel health benefits such as improvement in exercise capacity. These may be thought to be due to the action of dissolved hydrogen. There have been no researched studies of these in detail. The object of this study is to evaluate the effect of daily ingestion of AEW on health, including gastrointestinal symptoms, in subjects without any definite abdominal symptoms.

Participants and Methods

Participants

Healthy men and women (20–60 years) who use the Osaka City Citizen Health Development Consultation Center were selected as test subjects to determine the health effect of daily AEW ingestion. It was aimed to clarify whether general subjects without gastrointestinal symptoms have another good effect besides gastrointestinal symptoms by drinking AEW which is good for gastrointestinal symptoms. We explained this purpose to the subjects and asked for research participation. Written informed consent was obtained from all subjects. All procedures used in this research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018. This study follows the Consolidated Standards of Reporting Trials (CONSORT) guidelines. A double-blind, randomized controlled trial has been designed, and the research design is shown in Figure 1.

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Research design.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Subjects were randomly divided into two groups, with an AEW group (n = 30) and a PW group (n = 30). Blood tests, physical fitness evaluations, and questionnaire evaluations were conducted before the experiment was initiated. Subjects were provided with AEW apparatus that had been modified to produce only AEW or PW. They ingested 500 mL or more of freshly produced AEW or PW per day (they were required to ingest 200 mL immediately after awakening, and 300 mL or more during the rest of the day). After the end of the four-week period, blood tests, physical fitness evaluations, and questionnaire evaluations were conducted again to check whether the ingestion of AEW for four weeks had beneficial effects on the health of the subjects.

Blood sample/urinalysis

General blood test: Red blood cell count, white blood cell count, hemoglobin, hematocrit, and platelet count.

Blood biochemical examination: Total protein, albumin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), γ-GTP, total cholesterol, high-density lipoprotein (HDL), cholesterol, low-density lipoprotein (LDL) cholesterol, neutral fat, uric acid, creatinine, and blood sugar.

Urinalysis: Urine sugar, urine protein, urine occult blood, and urine pH.

Physical measurements

Right/left grip strength, right/left leg muscle strength, vertical jump, whole body reaction time, standing time on one leg with eyes closed, sit-up, seated forward bend, and resting blood pressure.

Questionnaire variables

Gastrointestinal symptoms (stomachache, heartburn, heavy stomach, lower abdominal pain, bloated stomach), urinary frequency, condition of the stools (fecal properties and bowel movement), and physical condition (sleep quality and upon awakening).

Statistical analysis

In the blood data, the urinalysis and physical measurement values, the statistical significance of the average difference (before and after AEW, PW drinking) was analysed using a paired t-test (Statcel 4 Software [OMS Publishing, Saitama, Japan). The questionnaire data (before and after AEW, PW drinking) was analysed by the Wilcoxon signed-rank test using the same Statcel 4 software. Differences for which Pvalues of < 0.05 and < 0.01 were inferred as significant.

Results

Conditions of subjects and water quality

Subjects with abdominal symptoms such as heartburn, stomach discomfort, abdominal bloating, diarrhea, and constipation were used in the study previously performed., For the current study, subjects aged 20 to 69 years were randomly selected among medical checkup examinees who visited the Osaka City Citizen Health Development Consultation Center, and then divided into two groups. One group ingested PW while the other ingested AEW. Neither the subjects nor the experimenters knew which group the subjects belonged to. Figure 2 shows that no significant differences were found in dispersion of mean values and distribution values.

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Age distribution of subjects.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Each subject was provided with an AEW apparatus that had been modified to either produce or not produce AEW, and asked to install it at their home. In order to verify the quality of the drinking water, the water produced by the apparatus was taken into aluminum containers and collected when the subjects came in for measurement. Figure 3 shows the water quality distribution of each drinking water.

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Water quality distribution of two types of drinking water.

Note: PW: Purified tap water; AEW: alkaline electrolyzed water.

Because we selected subjects who live in or around Osaka City, the tap water from either the same or a nearby water source was used for the evaluation. For this reason, the tests have been conducted using water of equivalent quality and which shows little bias in the distribution of ions.

Regarding the water before and after the electrolysis, the pH was 7.6 ± 0.2 for the PW group, and 9.2 ± 0.2 for the AEW group. Dissolved hydrogen concentration was not measurable at the subjects’ houses because hydrogen easily escapes water. However, for non-electrolyzed and electrolyzed tap water from the same water source and using the same water apparatus, the hydrogen concentration was confirmed as 0 mg/L in the PW group and 0.2 mg/L for the AEW group for the characteristics of the device.

Comparison of hematological values

The hematological data of subjects in the PW group and the AEW group were compared before and after the four-week period, but no significant differences were observed in both groups. This is consistent with the contents of the previous report. However, the HDL cholesterol level, a newly measured value this time, of the AEW group showed a tendency to increase with P = 0.097, as shown in Figure 4.

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Change in HDL cholesterol before and after drinking.

Note: (A) alkaline electrolyzed water (AEW) drinking group, (B) purified tap water (PW) drinking group. HDL: High-density lipoprotein.

Comparison of data related to physical abilities

For the seated forward bend, vertical jump, right/left grip strength, and sit-up, there was no significant difference before and after the 4-week period for both the PW group and the AEW group.

Regarding the whole body reaction time, no significant differences were observed before and after the 4-week period in the case of the PW group, as seen in Figure 5B. However, a significant difference (decrease) (P < 0.05) was observed in the AEW group, as seen in Figure 5A. As for standing time on one leg with eyes closed, longer times were observed in the AEW group (P = 0.09), as seen in Figure 6A.

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Change in whole body reaction time before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group; (B) purified tap water (PW) drinking group.

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Changes in the standing time on one leg with eyes closed before and after drinking.

Note: (A) alkaline electrolyzed water (AEW) drinking group, (B) purified tap water (PW) drinking group.

Questionnaire to subjects

As for the questionnaire items, we asked the subjects to provide answers in 3 to 5 points about gastrointestinal symptoms (Table 1), defecation and urination (Table 2), and physical condition (Table 3).

Table 1

Gastrointestinal symptoms

Item 1 2 3 4
Stomachache Not at all Slightly Quite a lot Very much
Heartburn Not at all Slightly Quite a lot Very much
Heavy stomach Not at all Slightly Quite a lot Very much
Lower abdominal pain Not at all Slightly Quite a lot Very much
Bloated stomach Not at all Slightly Quite a lot Very much

Note: Scoring 1 to 4, where: Not at all = 1, and Very much = 4.

Table 2

Defecation and urination

Item 1 2 3 4 5
Uninary frequency Very often Often Sometimes Occasionally Rarely
Fecal properties Hard Slightly hard Normal Slightly soft Soft
Bowel movement Very good Good Normal Bad Very bad

Table 3

Physical conditionn

Item 1 2 3
Sleep quality Good Neither nor Bad
Waking up Good Neither nor Bad

Note: Scoring 1 to 3, where: Good = 1, and Bad = 3.

First, as seen in Figures 77 to to11,11, as for gastrointestinal symptoms, sufficiently clear effect could not be confirmed in this study. Next, as seen in Figure 12, the urinary frequency significantly increased in both groups, likely due to an increase in urine volume resulting from water ingestion. Regarding bowel movement, the stools slightly changed from slightly soft to normal or slightly hard, or from soft to normal (P < 0.05) in the AEW group, as can be seen in Figure 13A. There was no difference between subjects of the two groups who had answered that they were in “good” or “bad” physical condition.

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Change in stomach ache before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in bloated stomach before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in urinary frequency before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Changes in the condition of stools before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Change in heartburn before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in heavy stomach before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

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Change in lower abdominal pain before and after drinking.

Note: Left side: alkaline electrolyzed water (AEW), and right side: purified tap water (PW).

Regarding sleep quality, there was a significant increase (P < 0.01) in the number of AEW group subjects who responded that they were able to sleep well, as shown in Figure 14A, and there was a significant increase (P < 0.05) in the number of subjects from the same group who said that they felt good upon awakening, as seen in Figure 15A.

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Change in sleep quality before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

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Changes in the state of getting up before and after drinking.

Note: (A) Alkaline electrolyzed water (AEW) drinking group, and (B) purified tap water (PW) drinking group.

Discussion

In Japan, AEW apparatus have been approved as medical devices, and ingesting AEW has been found to be effective in relieving gastrointestinal symptoms. A clinical evaluation of this effect was conducted with patients with gastrointestinal symptoms (heartburn, stomach discomfort, and abdominal symptoms such as abdominal bloating, diarrhea, and constipation).

Antioxidant action by hydrogen and gastric acid neutralization by alkaline pH have been considered. In addition, recent studies have shown that the intestinal bacterial flora distribution changes. It seems that these are involved in the normalization of the gastrointestinal activity. However, for this study, patients with gastrointestinal symptoms were not specifically selected. As for these as well as the previous results, in general, there was no difference in the hematological values between the PW group and the AEW group. However, the newly measured HDL cholesterol value showed a tendency to increase with P = 0.097. The increase in HDL cholesterol by ingesting water containing hydrogen is reported by Gadek and colleagues. The effect of hydrogen can be considered to have had an effect in the AEW group this time as well.

As for gastrointestinal symptoms—which showed a significant difference during the previous study (significant improvement of abdominal symptoms and improvement of abnormal bowel movement),—sufficiently clear effect could not be confirmed by this study because the subjects did not show gastrointestinal symptoms, and very few of them responded that they had abnormal abdominal symptoms and bowel movement before participating in this study. Therefore, we believe this is the reason the answers of the subjects were the same before and after their participation in the study.

However, with respect to bowel movement, the stools slightly changed from soft to normal or slightly hard, or from loose to normal in the AEW group. This reflects that the stools are more normal, and, as shown in the previous report, that ingesting AEW is considered to contribute to intestinal normalization.,,Regarding items other than the gastrointestinal tract, a high proportion of the respondents said that they felt they were able to sleep well, and the proportion of subjects who answered that they felt good when awakening increased. Various studies on the relationship between the ingestion of antioxidant substances and the condition of sleep have been undertaken, and the effect of reducing oxidative stress, thus allowing for improved sleep quality, is exhibited by ingesting AEW containing hydrogen, which is considered an antioxidant substance.

Regarding sports performance, various reports on the effects of sleep on sports performance have concluded that willingly sleeping longer can lead to faster running, shortened reaction time, and improved motivation during practice and games. Improved sleep quality by ingesting AEW is, therefore, believed to help reduce fatigue, ensure appropriate endurance recovery, and improve overall sports performance.

The findings of this study indicate that ingesting AEW on a daily basis improves health and exercise capacity, even in healthy people who do not have gastrointestinal symptoms.

Footnotes

Funding: The study was supported by a grant from Matsushita Electric Works Co., Ltd. Home Appliances R&D Center (to HN).

Conflicts of interest

The corresponding author (YT) is a salaried employee of the Panasonic Corporation. One of the authors (SY) was a salaried employee of the Panasonic Corporation. This study does not alter our adherence to Medical Gas Research policies on sharing data and materials. Another authors (KI and HN) report no conflict of interest related to this manuscript.

Financial support

The study was supported by a grant from Matsushita Electric Works Co., Ltd. Home Appliances R&D Center (to HW).

Institutional review board statement

All procedures used in this research were approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 837) and were registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000031800) on March 22, 2018.

Declaration of participant consent

The authors certify that they have obtained participant consent forms. In the form, participant have given their consent for their images andother clinical information to be reported in the journal. The patients understand that their names and initials not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Reporting statement

This study follows the Consolidated Standards of Reporting Trials (CONSORT) guidelines.

Biostatistics statement

The statistical methods of this study were reviewed by the biostatistician of the Osaka City University, Osaka, Japan.

Copyright license agreement

The Copyright License Agreement has been signed by all authors before publication.

Data sharing statement

Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices). Study protocol and informed consent form will be available immediately following publication, without end date. Results will be disseminated through presentations at scientific meetings and/or by publication in a peer-reviewed journal. Anonymized trial data will be available indefinitely at www.figshare.com.

Plagiarism check

Checked twice by iThenticate.

Peer review

Externally peer reviewed.

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Link to Publisher's site
. 2018 Oct-Dec; 8(4): 160–166.
Published online 2019 Jan 9. doi: 10.4103/2045-9912.248267
PMCID: PMC6352572
PMID: 30713669
Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms

References

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3. Hayakawa T. Functions and applications of alkaline ionized water. Food Styl. 1999;3:49–55.[]
4. Tashiro H, Kitahora T, Fujiyama Y, Bammba T. Clinical evalutaion of alkaline ionized water for chronic diarrhea- placebo controlled Double-blind study. Diges Absor. 2000;23:52–56. []
5. Yoshihide Fujiyama. Utility and reliability of alkaline electrolyzed water. The 27th General Assembly of the Japan Medical Congress Osaka. 2007:1–30. []
6. Hotta K, Saihara Y. Basic Information on alkaline ionized water (potable alkaline electrolyzed water) – scientific and social basis and perspectives. Functi Water. 2017;12:35–44. []
7. Xue J, Shang G, Tanaka Y, et al. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complement Altern Med. 2014;14:81. [PMC free article] [PubMed[]
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11. Zhang W, Zhang Q, Yao W. Intestinal microbiota ecological response to oral administrations of hydrogen-rich water and lactulose in female piglets fed a Fusarium toxin-contaminated diet. Toxins (Base) 2018;10:E246. [PMC free article] [PubMed[]
12. Muramatsu, S, Fujiwara K, Ito M, et al. Effect of electrolyzedreduced water ingestion on the changes of biochemical markers under the graded exercise test, Studies on humanities and social sciences of Chiba University. 2010:1–15. []
13. Fujita K, Seike T, Yutsudo N, et al. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One. 2009;4:e7247. [PMC free article] [PubMed[]
14. Hamasaki T, Harada G, Nakamichi N, et al. Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. PLoS one. 2017;12:e0171192. [PMC free article] [PubMed[]
15. Shirahata S, Hamasaki T, Teruya K. Advanced research on the health benefit of reduced water. Trends Food Sci Tech. 2012;23:124–131. []
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Articles from Medical Gas Research are provided here courtesy of Wolters Kluwer — Medknow Publications

ionized water – mith or fact

Apa ionizata- Proprietati si Beneficii pentru sanatate demonstrate

Apa ionizata -adevar si/sau  fals .

Introducere

Oricine a fost abordat de cineva ce vinde aparate purificat –  ionizat apa (ionizator cu filtru apa) dorește mai multe informații.

Dar avand in vedere ce reclame pompoase se fac ,cate din acestea sunt si adevarate?

Ca sa va convingeti, dati o cautare pe un motor cautare  gen Google si veti vedea fel de fel de afirmatii ale diversi   promotori de apa ionizata precum : schimbati viata cu apa ionizata, vindeca diabetul si cancerul si “toate bolile”.

Cate din ele sunt adevarate si cate sunt false ?

Internetul este adesea primul lucru la care  oamenii  recurg pentru cercetare, si gasim adesea două extreme: fie oameni care încercearca cu orice pret sa va vanda un aparat de filtrat/purifcat – ionizat apa si il vor ridica in slavi ca fiind solutia magica la toate probleme dvs, fie cei care afirma ca aceastea sunt o fraudă si nu au nici o dovada

Deci,pe cine si ce să crezi cand vine vorba de apa ionizata si aparate purifcat -ionizat apa?

Poate ca cel mai corect si simplu raspuns la prima vedere ar fi sa cautati sa discutati cu CONSUMATORI de apa ionizata( oameni ce folosesc aparate purificat- ionizata apa pentru uz pernsonal si NU vand astfel de produse ) si sa aflati opinia lor, bazata pe experienta lor personala dupa mai multi ani de consum .Acestia nu au interes nici sa  ridice in slavi apa ionizata nici sa o blameze.Cu siguranta acesta este un punct de reper mult mai bun decat vnazatorii sau cei ce neaga total din alte interese.

NOTA AUTORULUI: personal am aflat despre beneficiile apa ionizata intnad in contact cu fosti bolnavi /oameni cu diverse afectiuni care au relatat ca apa ionizata (alcalina si acida) i-au ajutat sa-si depaseasca conditia de sanatate

Totusi, cum fiecare organsim e unic si nu toti suntem construiti la fel deci corpurile noastre nu raspund/reactioneaza  la fel la lucruri identice(deci nici la apa ionizata ),  haideti sa plecam de la ce se cunoaste referitor la apa ionizata si aparate purificat -ionizat apa.

Notiuni precum   apa filtrata / “purificata” minerala – apa minerala FARA contaminanti apa alcalina cu  pH EXTREM de alcalin ,  apa bogata in oxigen activ ,  apa cu  milioane de ioni de hidroxil per pahar si apa ce ofera un puternic ANTIOXIDANT , numit -ORP  , apa structurata cu legături de hidrogen,  apa structurata molecular în grupuri/clustere apa  de 4 – 6  molecule H20 , apa cu  formă  hexagonala( apa fulg de zăpadă -apa Masaru Emoto), apa VIRGINA – apa ” PURA “ (apa a carei  memorie electromagnetica EMF a fost  RESETATA la ZERO) , apa VIE (NUMAI apa ionizata alcalina are această calitate) , apa cu proprietati super conductive ,  apa cu tensiune joasă de suprafață si altele sunt proprietati cunoscute asociate cu apa ionizata , proprietati care fac apa ionizata superioara altor tipuri si surse de apa din zilele noastre, proprietati pe care si  laureatul premiului Nobel, conationalul nostru, Dr Henri Coanda le-a studiat in apele ionizate naturale care apar in vaile nedistruse inca de om: Valea Hunza, Vilcabamba (Euador), Georgia din fosta URSS si alte cateva locuri izolate din lume.

 

DA, corpul uman este 70-80 % apa(deci apa este foarte importanta, mai importanta decat ce mananci si pina nu iti spune cineva ca esti 70-80% apa nu realizezi cat de importanta e apa pentru viata de fapt), DA, apa ionizata de un purificator – aparat apa hidrogenata / ionizator apa de calitate( care are si filtre apa ce elimina toti contaminantii dar lasa o apa pura si minerala si foloseste materiale de calitate precum placi de ionizare apa din platina titan ce necesita putere electrica mica , certificate a nu emite lucruri toxice in apa precum iridium sau nichel (electrozii din otel inox home-made)  si nici platina( precum placile de ionizare apa DIPPED)  ) ajuta/poate ajuta  cu multe  afectiuni si probleme de sanatate, insa de aici si pina la a promova un purificator – ionizator de apa pina la solutia minune pentru toate problemele doar pentru a justifica preturile supraumflate datorate politiclor MLM(sistem piramidal) e drum lung.

Ce este FAPT este ca apa ionizata e folosita in spitale si centre medicale din Japonia, Korea, China si alte tari din Asia ca si tratament adjunvant STANDARD(vorbim ca medicina primara, NU alternativa) cat si pe scara larga –  uz curent de catre oricine de peste 30 ani

  • Știați că 15 % din populația din Japonia, care bea apa alcalina ionizata de la ionizatoare de apa au o speranță de viață de 10 ani , IN PLUS, mai mult decât cei din Statele Unite ale Americii ? Și au băut apa ionizata pentru o medie de doar 12 de ani! Gândiți-vă în cazul în care s-ar fi apucat de băut apa ionizata de la naștere !

Acestea sunt locatiile unde s-au efectuat cele mai multe studii stiintifice si teste clinice cu apa ionizata, lucruri care au inceput sa se petreaca si in tari vestice :

Cateva cuvinte despre cine suntem noi si de unde venim, pentru a intelege de ce vrem sa va prezentam fapte:

EMCO TECH (ex Jupiter Science )- CEL MAI MARE  PRODUCATOR aparate purificat – ionizat apa din LUME

EmoTech (Jupiter Science) este  cel mai mare producător purificatoare – ionizatoare de apa de pe GLOB . ce a vandut purificatoare – ionizatoare apa în întreaga lume mai multe decât orice altă marcă de purificatoare – ionizatoare apa.

Departamentul R&D – Cercetare și Dezvoltare al EmcoTech(Jupiter) din Japonia, cu un personal de peste  20 de cercetatori la nivel de doctorat(pHD), produce cele mai   avansate tehnic, eficiente  PERFORMANTE si  DURABILE  aparate purificat /filtrat – ionizat apa – realizeaza întotdeauna mai mult cu mai puțin(spatiu, putere , etc).

NOI, ALKAVIVA SUNTEM MANDRII SA FIM IMPORTATORUL (DISTRIBUITORUL ) UNIC DIRECT  FABRICA pentru aparate purificat /filtrat – ionizat apa EMCOTECH (JUPITER)

AlkaViva (ex IonWays)

Suntem cea mai veche și experimentata companie  de aparate purificat /filtrat – ionizat apa si accessorii pentru acestea  din SUA.

Purificatoarele- ionizatoare apa AlkaViva(IonWays) au fost vândute pe piața americană de 16 ani!
Mai mult decât toate celelalte mărci purificatoare – ionizatoare apa puse împreună.
Am vândut cu amănuntul aparate purificat /filtrat – ionizat apa în Statele Unite ale Americii, Canada și în aproximativ 30 de țări din întreaga lume (inclusiv Autralia, Noua Zeelandă și Marea Britanie).
Suntem importatori  directi de cele mai bune aparate purificat /filtrat – ionizat apa(fabricate de EmcoTech  ( Jupiter) , importatori  EXCLUSIVI) cat si producatori de tehnologii apa si accesorii pentru acestea: filtre  apa exceptionale, kituri montare aparat purificat/ filtrat – ionizat apa subchiuveta, solutii si prefiltre apa pentru probleme specifice apa, etc. Avem o echipa de experti in apa cu care  oferim suport , garantie si service aparate ionizat- purificat /filtrat apa, si obtinem certifcari si aprobari pentru aceste aparate purificat / filtrat – ionizat apa. 
NU am vandut mereu aceste marci de aparate purificat /filtrat – ionizat apa. Impreuna, noi cei de la AlkaViva am vandut si alte marci aparate purificat /filtrat – ionizat apa considerate de top precum Kangen EnagicTM, Toyo, AlkaBlue, Nexus, KYK, Tyrent, Life Ionizer si multe alte firme aparate purificat /filtrat – ionizat apa auto- promovate ca fiind de TOP(nu vom  include si aparate ieftine calitativ made in China/Taiwan gen Chanson ,etc). Cu toate acestea ,acum suntem TOTI convinsi ca aparate purificat /filtrat – ionizat apa Emco Tech (Jupiter Science) sunt cele mai bune. Pur si simplu cele mai bune aparate purificat /filtrat – ionizat apa disponibile.

BREVETE, PREMII si CERTIFICARI aparate purificat /filtrat – ionizat apa

EmcoTech (Jupiter Science) face aparate purificat /filtrat – ionizat apa in Coreea si Japonia (plăci de ionizare apa din  PLATINA-TITAN JAPONEZE,  NU copii iridiu si otel inox made China sau Taiwan ), din 1982, împreună cu alte companii importante, cum ar fi Samsung , LG, Toyo și Hyundai și deține mai multe brevete, premii si certificari aparate purificat /filtrat – ionizat apa decat toate celelalte branduri.

 
AlkaViva (IonWays) este singura compania aparate purificat /filtrat – ionizat apa en gros pentru a avea fabricatie “verde” , calificata prin Certificatul Sistemului de Management de Mediu ISO 14001:2004
De asemenea, aparate purificat /filtrat – ionizat apa CERTIFICATE ca dispozitive medicale in Japonia, Corea, China și multe alte state.
Cu zeci de certificări, premii, brevete, modele de aparate purificare / filtre – ionizare apa și noi tehnologii, este ușor de înțeles de ce suntem LIDERI GLOBALI aparate purificat /filtrat – ionizat apa .
Compania AlkaViva / EmcoTech reprezinta cel mai vechi si cel mai inalt standard de calitate in domeniul aparate ionizt- purificat( filtrat ) apa din LUME si nu isi permite sa cada in mirajul falselor afirmatii in ceea ce priveste beneficii si proprietati apa ionizata si purificata , riscand sa-si pericliteze renumele mondial, renume care in domeniul sanatate alternativa( “vestica”) nu e tocmai usor de obtinut.
Vrem sa va punem la dispzitie tot ce este necesar pentru ca dvs sa cunoasteti tot ce doriti despre apa ionizata :
Mai întâi vom clarifica terminologie esențială. Două măsurători de apă care sunt utilizate pentru a evalua performanta ionizatoare apa  pH și ORP.
1. Ce este pH-ul?
Este o scară de acid-alcalin care variază de la 0 la 14. neutrul este 7. Mai puțin de 7 este acid și mai mare decât 7 este alcalin. Când măsurăm pH apa  ionizata de fapt  măsuram cantității de ioni de hidrogen prezente în apa ionizata. pH< 7, apa ionizata acid se referă la cantitatea de ioni de hidrogen (H + ) majoritari în apa, în timp ce pH-ul>7 apa ionizata alcalina se referă la compuși majoritari care doresc să se lege cu hidrogenul ( OH-) PH-ul este o funcție exponențială. Un pH de 10 este de zece ori mai alcalin ca un pH de 9 și o sută de ori mai alcalin ca un pH de 8, și așa mai departe.
Limitele stabilite EPA pH apa potabila acceptabile pentru consum  sunt între 6,5 și 8,5.
Nu este indicat a se consuma apa cu pH >10.
Proprietatea de pH apa ionizata-adevar sau mit? Adevar.
Poate fi masurat pHul apa ionizata? Desigur.
Cum paote fi masurat pHul apa ionizata? Utilizand fie un pH metru bine calibrat de un laborator certificat si calificat sa faca astfel de calibrari si masuratori sau, daca doriti sa verificati acasa, metoda ‘babeasca’ dar mai precisa decat un pH metru care nu e calibrat corespunzator este cu picaturile reactive functie de pHul apa ionizata care vin impreuna cu orice aparat ionizat-purificat(filtrat) apa AlkaViva (Jupiter) sau cu hartii turnesol reactive functiede  pH apa ionizata.

2 . Ce este ORP apa ionizata?

Acest acronim vine de la Potential de Reducere Oxidare(ORP)
.
Functie de tipul de ionizare apa ales,apa ionizata poate fi apa oxidativa (apa ionizata acida, cu exces de H+) sau apa antioxidant (apa ionizata alcalina, cu exces de ioni OH-)
Caracterul oxidativ/ antioxidant apa ionizata e dat de sarcina electrica ( deficitul sau excesul de electroni ). De exemplu, electronii liberi in exces din apa ionizata alcalina( abundenta de OH- implica un exces de electroni liberi donori) se vor cupla cu radicalii liberi de oxigen si vor anula astfel daunele de oxidare .
Când o moleculă renunță un electron , molecula este oxidata. Pe partea cealaltă a ecuației, atunci cand o molecula are un electron in exces acesta este redusa.
Proprietatea de ORP (caracter oxidativ sau antioxidativ) apa ionizata-adevar sau mit? Adevar.
Poate fi masurat ORPul apa ionizata? Desigur.
Cum paote fi masurat ORPul apa ionizata?  Numai un ORP metru bine calibrat de un laborator certificat si calificat sa faca astfel de calibrari si masuratori .Nu se recomanda testarea acasa cu ORP metre care nu sunt calibrate exact.De foarte multe ori in practica, citirile cu ORP metre acasa s-au dovedit false(fie arata mai mult sau mai putin dar de purine ori exact) ,
Măsurarea ORP implica simplist măsurarea milivolților din apa  creati de molecule care doresc să ia electroni și de molecule care doresc să doneze electroni.
ORP pozitiv indică potențialul pentru mai multe molecule dornice să ia un electron( H+) decât moleculele dornice de a da un electron(OH-). In tratamentul traditional apa cu clor, măsurarea ORP pozitiv poate indica puterea de oxidare a clorului în apa.
ORP negativ indică faptul că există mai multe molecule dornice să renunțe la un electron și sa devina oxidate decât invers(molecule OH > molecule H+). Aceste molecule sunt antioxidanti, deoarece acestea anuleaza molecula de oxidare, oferindu-le ceea ce doresc – un alt electron.
Este teoretizat ca efectul de sănătate de molecule antioxidante este capacitatea lor de a proteja tesuturile organismului de a fi oxidate, se sacrifica prin renuntarea unui electron la oxidant.
 NOTE:
2.a. Cand vine vorba de pH si ORP apa ionizata alcalina,aparatele purificat / filtrat – ionizat apa AlkaViva (IonWays) / EmcoTech ( Jupiter)  sunt garantate pentru a surclasa orice altă marcă, indiferent de pret aparate purificat /filtrat – ionizat apa sau dimensiuni placi ionizare apa si putere electrica aplicata pe placile de ionizare apa. Aparatele purificat /filtrat – ionizat apa AlkaViva (IonWays) / EmcoTech ( Jupiter)  sunt cele PERORMANTE, FIABILE  si DURABILE  aparate purificat / filtrat – ionizat apa din LUME,asa cum rezulta si din testele laborator stat, guvernamental, certificat EPA SUA cat si din practica.

Aparate purificat /filtrat – ionizat apa AlkaViva (IonWays) / EmcoTech ( Jupiter)  necesită mai puțina putere aplicata pe  plăci electrod de ionizare apa  si placi de ionizare  apa mai compacte, ocupa mai puțin spațiu și sunt garantate pentru a depasi in performante ionizare apa orice alta marca de purificator- aparat apa hidrogenata / ionizator apa, indiferent de preț aparat purificat /filtrat – ionizat apa  .
Alte marci de aparate purificat /filtrat – ionizat apa  de ce nu pot prezenta astfel de teste INDEPENDENTE, CERTIFICATE? 
2.b. NU toate ionizatoarele folosesc DOAR electroliza apa pura.Manualul pentru modelul LeveLuk făcută de Enagic® (apa alcalina se numește apa Kangen®)  prevede folosesc un lichid “amplificator electroliză,” deși nu se specifică ce conține. Enagic® folosește, de asemenea, calciu Acid glicerofosforic pentru a crește concentrația de pH.
Uneori(poate chiar de multe ori) unii dealeri Kangen incearca sa induca in eroare afirmand ca ” apa kangen ” este altceva.Totusi acest articol nu isi propune de dezbata “apa kangen”.Adevar si mit apa kangen aici

2.c. Toate ionizatoarele apa AlkaViva pot produce niveluri impresionante de pH si ORP  insa sunt optimizate special pentru PH si ORP sănătoase și benefice(ORP bun la valori 7<pH<10) – veti observa ca desi TOATE ionizatoarele AlkaViva ating niveluri impresionante de PH si ORP, NU pH si ORP extreme va intereseaza ci apa cu proprietati , pH si OPR cat mai apropiate de apa naturala, asa cum se gaseste spre exemplu si in “valea de longevitate” Vilcabamba , Ecuador  pe care AlkaViva a studiato. Exista 5 locatiii in lume  unde cercetatorii au descoperit astfel de ape cu proprietati unice ,unde oamnii traiesc peste 100 ani cu sanatate exceptionala, NU au cancere, NU au nici …carii . Hunzaland in Muntii Karkorum, Vilcambamba in Ecuador, o vale muntoasa Georgia, Russia, alta  in Mongolia si una in Peru. Toate au culturi si diete diferite si un lucru comun – apa lor are proprietati similare! 2008145_48624 Am fost acolo si am studiat.Daca doriti sa stiti mai multe detalii vizualizati DVDul GRATUIT- completati formularul : [contact-form subject=’Valea DVD’][contact-field label=’Email’ type=’email’ required=’1’/][contact-field label=’Comentarii’ type=’textarea’/][/contact-form] Aceasta optimizare este rezultatul a peste 30 ani experiente si cercetari , istorie UNICA, ce ne face LIDERI MONDIALI in domeniul ionizatoare apa   ) care, alaturi de  aprobarile medicale  au facut din aparatele filtrare – ionizare apa AlkaViva si alegerea expertilor internationali in domeniu  precum prof Dr. Robert O. Young , Dr. Ted Baroody , Sang Whang si a multor altor experti si spitale si centre medicale.(a se vedea fila APROBARI 

 
Desigur  pH si ORP sunt indicatori  apa ionizata cei mai cunoscuti,insa nu neaparat cei mai importanti.
După cum a spus lauretul premiului Nobel, Henri Coanda, dupa studii ale apelor intalnite in vai longevitate precum Hunza , apa este benefică atunci când ea are următorii parametri: pH apa 7-9, potențialul redox ORP apa -100mV -700mV,  tensiunea superficială apa 43-45 din/cm și structură hexagonală apa . Există, desigur, alți parametri care trebuie considerati cum ar fi puritate apa,  mineralizare apa , conductivitate apa , vitalitate apa și altele.
In contiunuare dezbatem cateva din cele mai importante(inclusiv pe cele masurate de romanul lauret cu NOBEL, Dr Henri Coanda)
3.De examplu apa alcalina ionizata este apa structurata molecular în grupuri/clustere apa  de 4 pana la 6  molecule H20 .
Rezonanța magnetică nucleară a arătat că aceasta este o treime din dimensiunea moleculara a altor ape , care are grupuri de 10 până la 15 molecule .
Această reducere grup ajuta celulele sa absoarba apa ionizata rapid și eficient pentru ca patrunde si dizolva mai usor, fiind apa redusa in dimensiuni cluster(apa microgrupata)
Demonstratia cea mai simpla a acestui fapt o reprezinta testele cu apa ionizata cu pH > 10 in care uleiul de integreaza in loc sa pluteasca la suprafata, apa ionizata in care fructele si legumele si mancarurile isi lasa chimicalele pe baza de uleiuri, etc
Si acest lucru il veti simti si fizic pe pielea dvs pentru caveti bservacaveti putea bea mai mutla apa-apa nu va “pluti” in stomac.
NOTA: NU se iau medicamente cu apa ionizata alcalina tocmai din acest motiv- se dizolva si se absorb mai rapid
4.Apa alcalina ionizata OXIGENEAZA organismul printr-o creștere a raportului  de oxigen / hidrogen .(abundenta de OH- inseamna un raport mai mare de oxigen raportat la hidrogen fata de cel intalnit in H20) Celelalte ape sunt lipsite de acest beneficiu .Implicatiile acestui lucru sunt multiple pentru sanatate , energie si vitalitate Apa alcalina ionizata oxigeneaza organismul dumneavoastră mai eficient decât orice alt tratament ” oxigen “/terapie ozon  si este usor de administrat si tolerat de organism fata de terapiile ozon ce injecteaza ozon gaz in sange sau alte terapii ozon pe care nu toti le pot tolera sau nu si le permit.
Iarasi,un efect pe care il veti simti pe pielea dvs cand veti avea simptome de raspuns imunitar(simptome de raceala, etc) la trecerea la consum de apa ionizata alcalina.De aceea se recomanda trecerea TREPTATA si NU brusca la apa ionizata alcalina, incepand cu apa  alcalina ionizata foarte putin si crescand gradul de ionizare apa pe masura ce orgasnimul dvs se obijnuieste
5. Apa alcalina ionizata este APA VIE .
Ce este /despre apa vie?
Toti electroni din apă , sunt fie de spin/rotatie la stânga sau la dreapta .  Cu cat mai mare viteza de rotire stânga a electroni cu atat apa este considerata a susține vitalitatea -apa vie . Numai apa ionizată alcalina are această calitate .
PROPRIETATE MASURABILA(REALA)-DA.
Stiati ca aparatele filtrare- ionizare ( alcalinizare ) apa AlkaViva au fost testate in laborator pentru a vdea in ce masura incarca apa de vitalitate(cata forta de viata capata apa odata ce trece prin ele), si cumparate cu alte ape considerate a fi vii, inclusiv cu apa Kangen?
“Apa alkalina vie este privita de un numar de profesionisti sanatate ca fiind cea mai buna apa de baut si este listata ca dispozitiv medical in Japonia pt tratarea bolilor degenerative.”  
Dr Hidemitsu Hayashi Chirurg inima ,  Director al Institutului apa al Japaniei
Acestea de mai sus sunt FAPTE.Exista si proprietati asociate cu apa ionizata ce pot fi contestate (intr-ucat necesita aparatura mai sofisitcata pentru testare) precum
6.Apa ionizata are forma hexagonala- apa “fulg de nea”.
7.Apa alcalina ionizata este  APA  ” VIRGINA “- memorie electromagnetica RESETATA la ZERO .
Tot la ce a fost apa expusa lasă o semnătură de frecvențe electromagnetice sau amprenta electromagnetica(de camp magnetic- EMF).
Frecvențe negative ( exemplu : apa de la robinet reciclate de canalizare ca în majoritatea orașelor mari ) sunt asociate cu boli . Apa ionizata este apa virgina , deoarece memoria camp electromagnetic EMF au fost ” resetata”, deci nu are acele amprente nocive, asociate cu bolile.
8 .FAPT IMPORTANT  insa  este ca sistemele purificat – ionizat apa ar trebui sa ofere o pre-filtrare apa minima pentru îndepărtarea clorului si a altor contaminanti fara a demineraliza apa
TOATE aparatele filtrare – ionizare apa AlkaViva, includ acum GRATUIT exceptionalele si inegalabilele filtre apa UltraWater ,( produs brevetat AlkaViva) ce oferă cea mai bună filtrare apa interna, creata vreodata pentru ionizatoare apa .
Filtrul apa UltraWater filtrează  apa de TOTI contaminantii  cunoscuti (inclusiv cloruri,cloramina , fluoruri, nitrati, nitriti, detergenti, cianuri, chimicale, reziduuri din exploatari miniere si din gaze sist din apa ,etc) cu o precizie uimitoare de de 99.9% si NUMAI DE contaminanti,  lasand mineralele benefice organismului, prezente in mod natural in apa , sa treca de filtru apa(spre deosebire de apa filtrata Osomoza Inversa, apa puridficata, si apa distilata (inclusiv Apa Sarcita in Deuteriu prin distilare vid)  care spala din organism mineralele benefice )
Acuratetea si perfomanta de filtrare apa Ultrawater sunt de asemenea confirmate si certificate de teste laborator guvernamental, independent certificat NELAP EPA SUA. detalii si rezultate teste laborator ULTRAWATER -click aici
Deci veti bea nu doar apa ionizata alcalina, dar si FARA contaminati ( dar NU apa purificata total ), apa ce include DOAR minerale benefice.Apa minerala FARA contaminanti(FARA nitrati, FARA cloruri, FARA fluoruri, FARA pesticide, FARA chimicale, etc)
Tehnologia de filtrare apa UltraWater – pentru îndepărtarea 99,9 % contaminanti  înseamnă că nu numai este apa filtrata de impurități la cele mai ridicat grad posibil , dar este , de asemenea,  precondiționată prin reducerea tensiunii superficiale apa pentru producție maximă de ioni negativi in timpul ionizarii apei .  Nu există nici un substitut pentru  calitatea acestui filtru apa ionizata  . Noul sistem uimitor de filtrare apa UltraWater  înseamna filtrare apa exceptionala  si energizare  .
AlkaViva este SINGURA companie ce fabrica filtre apa pentru ionizatoare de apa  în Statele Unite ale Americii la standardele RNP ,NELAP EPA si foloseste DOAR materiale naturale, inclusiv Tourmalina. Acest lucru înseamnă:

  • reducerea dimensiunii de micro-cluster apa in mod natural
  • alcalinizare apa in mod natural
  • creșterea DO ( oxigen dizolvat )apa in mod natural
  • gust sporit si minimizarea miros apa
  • Energia FIR(Far InfraRed) pe care Turmalina o emite natural produce o rezonanță în organism la aceeași frecvență ca și apa .

Intr-ucat cei mai multi oameni doresc sa bea apa ionizata alcalina din motive de sanatate,  doriti sa beti  nu doar apa ionizata alcalina, dar si apa filtrata FARA contamianti( dar NU apa purificata precum apa filtrata Osomoza Inversa si apa distilata(inclusiv Apa Sarcita in Deuteriu)  care spala din organism mineralele benefice ), ci apa  bogata NUMAI in minerale benefice( FARA contaminanti precum nitrati, cloruri si floruri , chimicale, pesticide si altii intalniti in apa chiuveta) –  apa care sa va DETOXIFICE  FARA sa va  demineralizeze, apa care sa va ajute sa va recapatati sanatatea fiecarei celule, deci filtrarea apei la cel mai inalt nivel NUMAI de contaminanti apa ar trebui sa fie una din principalele caracteristici urmarite la un aparat filtrare – ionizare  apa.

Tehnologia filtrare apa ULTRAWATER  este acum oferita GRATUIT, in PLUS  la filtrele apa ionizata  Biostone Plus 0.1 micron
De ce sa cumparati un aparat apa hidrogenata / ionizator apa care nu ofera o apa curata?
 Apa ionizata alcalina ce contine contaminanti NU e o apa sanatoasa!
Stiati ca, reziduuri nefiltrate (in special clorurile) din apa ce pot ajunge in camera ionizare apa pot capata structura mult mai nociva in urma ionizarii apei nefiltrate corespunzator?
CONTACTATI-NE  pentru o consultatie GRATUITA!
MOTTO AlkaViva:
“Take back your tap water! – Luati inapoi apa de la chiuveta!”

DE CE SA CUMPARATI DE LA NOI, ALKAVIVA:

TOTUL DESPRE aparatele purificare /filtre –  IONIZATOARE APA:

APA ALCALINA IONIZATA, APA VIE SI SANATATEA:

  • Companiile partener cu vechime maxima ,  cele mai de încredere și de succes  in domeniul purificatoare /filtre-  ionizatoarelor de apa din LUME.
  • EMCOTECH(ex Jupiter Science) a produs și a vândut milioane de purificatoare /filtre – ionizatoare de apa la nivel mondial inca din 1981 si este LIDER  MONDIAL ce conduce prin PERFORMANTE ionizare apa ( asa cum rezulta din teste laborator independent, stat, certificat EPA )  ,calitate, fiabilitate si DURABILITATE(prin sistemele brevetate auto-curatare  placi ionizare apa testate si dovedite in timp) , 
  • Deține cele mai multe PREMII,CERTIFICARI, BREVETE si RECUNOASTERI OFICIALE INTERNATIONALE si are CELE MAI mici RATE DEFECTARE si RETURNARE din industria purificatoare / filtre – ionizatoare apa ( sub 1% )  
  • Singurele purificatoare / filtre – ionizatoare de apa cu certificari CE (Europeana), CSA și UL și certificări “dispozitiv medical” (Japonia Coreea si multe alte state);
  • tehnologie 100% japoneza (NU China, Taiwan) , placi ionizare apa 100% platina-titan (NU iridium, NU otel inox)
  • ALKAVIVA(ex IonWays importatorul)are mai multa experienta  decât TOATE celelalte mărci impreună(>16 ani)  si completeaza cu CELE MAI BUNE si SANATOASE FILTRE APA EXISTENTE  (filtrare apa certificata laborator de 99.9 din TOTI contaminantii apa, FARA demineralizare)oferite acum CADOU IN PLUS la filtrele standard ,SPECIALISTI APA CALIFICATI (care sa va ajute cu rezolvare problemelor apei dvs specifice GRATUIT), SUPORT  CLIENTI si SERVICE IONIZATOARE APA IREPROSABILE (evaluare maxima A+ cu BBB) si GARANTIE IONIZATOR APA MAXIMA
  • Garanție pe viață SUA, 5 -10 ani EU
  • Peste 30 ani experienta a expertilor nostri in apa si consultații GRATUITE apa pentru a determina cea mai bună soluție pt dvs.
  • Cea mai bună gamă de aparate purificatoare / filtre-ionizatoare  apa pentru toate nevoile si BUGETELE
  • PRETURI PURIFICATOR / FILTRU – IONIZATOR APA DECENTE identice cu cele intalnite si la partenerii AlkaVIva de peste ocean
  • Partener oficial AlkaViva (nu doar  importator EmcoTech) implicit TOATE avantajele de mai sus si CERTITUDINEA ca VOM FI PREZENTI pentru SUPORT, SERVICE, PIESE DE SCHIMB si FILTRE APA pt IONIZATOARE APA mult timp dupa ce alte companii  au venit si plecat.

30zilefcgri  buton-afla-mai-multe-eliberare

ce inseamna ionizare apa – ce este apa ionizata alcalina  pH, ORP  proprietati si beneficii unice apa ionizata apa ionizata si scepticii

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DVD + EBOOK: apa ionizata allcalina ALKAVIVA si apa din VALEA LONGEVITATII VILCAMBA, ECUADOR 2008145_48624 SECRETUL VITALITATII,  ENERGIEI si LONGEVITATII  CARTEA ELECTRONICA (EBOOK) DESPRE APA IONIZATA ALCALINA si  ECHILIBRUL ACID ALCALIN water-therapy-structured-water COMPARATIE APA IZVOR, APA POTABILA CHIUVETA, APA FILTRATA OSMOZA INVERSA, APA DISTILATA si APA SARACITA IN DEUTERIU SI APA IONIZATA ALCALIN – APA VIE
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Water ionizer certificates

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water ionizers / purifiers FAQ

Water ionizers & ionized water FAQ

Answers to  frequently asked questions about water ionizers/water purifiers  and water ionization technologies.

My new AlkaViva water ionizer has residual water in it. Is it used? Every NEW AlkaViva water ionizer is extensively tested by the manufacturer(EmcoTech/Jupiter water ionizers) to ensure proper operation before they are shipped to the AlkaViva warehouse. Therefore, there may be residual water drops coming from the bottom hose connectors. Not to worry, your NEW AlkaViva water ionizer/water purifier is not used.

What’s the best way to store alkaline ionized water?

“How can I store ionized water from my water ionizer? What kind of container should I use?” Whether you want to take your water to work or out to play, or whether you just want to chill your alkaline water in the fridge before you drink it, there are some things you should know. 1. ionized water from an water ionizer is best if consumed directly from the water ionizer immediately after producing it.  Ionized water has a high electron charge, which gives it its antioxidant qualities. Time, heat and light can cause the water to lose its charge, and therefore lose the unique properties & benefits of alkaline ionized water. Yes, you’ll still have clean, filtered and mineralized water… but you also want to be able to retain the low negative ORP that is one of the primary reasons for owning a water ionizer in the first place. I always use the analogy of fresh fruits & vegetables wich are best consumed right after they are picked otherwise they lose many valuable healthy benefits . Well, the same goes for ionized water. The same can be said about ionized water. When alkaline water comes out of a water ionizer it contains a negative ORP (an abundance of free, unbound electrons).  When stored in a container the ionized water will begin the process of losing its antioxidant quality as it “normalizes” with its surroundings.  How long that process takes to complete is based on the material and construction of the container that the ionized water is in. The antioxidant power in alkaline ionized water can decline in as little as 24 hours without proper storage, and pH levels would fall in about three days. Stored properly, alkaline ionized water can maintain high potency for about a week.

How To Store Your Ionized alkaline Water \

Glass Glass is always the preferred method of storing alkaline ionized water.

  • If using a glass container, try to use a UV protected glass, which is usually a dark color.
  • Fill storage container up to the top, thus limiting the alkaline ionized water’s exposure to air.
  • Store the container in a cool, dimly lit location. Avoid exposing the ionized alkalien water to heat and sunlight.
  • Drink stored alkaline ionized water within 72 hours for optimal quality and freshness.

Stainless Steel Regular stainless steel bottles are great for keep ionized alkaline water clean, as there is no “leaching” of dangerous chemicals from the container. But, the alkaline ionized water will quickly lose its antioxidant properties as the metal of the container is a conductor of electricity.  Therefore, if you are going to use a stainless steel container, be sure that it is a double-walled vacuum sealed bottle, as those types of bottles will slow down the ORP equalization rate.  Using these types of a bottles not only help to maintain the antioxidant properties of the alkaline ionized water, but are an excellent way to keep the water nice and cold during hot weather.

Plastic containers Plastic should be used as a last resort.for storing alkaline ionized water.  The only plastic bottles you should ever use should be made from certified BPA-free plastic.  Even when using this type of bottle, you are not guaranteed that your bottle will not leach other types of chemicals into your drinking alkaline ionized water.  Therefore, I would stay away from plastic bottles, if at all possible.

Keep Your ionized alkaline Water Refrigerated Refrigeration or freezing helps maintain the potency of alkaline ionized water. The alkaline ionized water should be put in a sealed container, and chilled immediately after it is made.  Also, if you enjoy putting ice in your water I would suggest getting yourself some stainless steel ice trays, and then make ice using your water ionizer water.  You don’t want to use ice that is made from your refrigerator’s ice-maker, as it is likely full of toxins that won’t be removed by the refrigerator filter, including fluoride.

Ionized water Right From The Water Ionizer Is Best There’s nothing more refreshing than a glass of healthy alkaline ionized water. Gotten fresh from a home water ionizer, alkaline ionized water has high negative ORP and a higher pH than plain water.

Drinking alkaline water straight from the water ionizer is always best because the beneficial qualities of the alkaline ionized water remain intact. This is the reason why ionized water cannot be sold as stored , the same reason why miracle waters from Hunza or Vilcabamba cannot be stored & sold. We know – we went to Vilcabamba, Ecuador to meet with the people in the Valley of Longevity and tested their water. If interested, please ask for our FREE DVD on this trip contact us or leave your mail address( we will not share it with anyone)  [contact-form subject=’Valley DVD’][contact-field label=’Email’ type=’email’ required=’1’/][contact-field label=’Comments(optional)’ type=’textarea’/][/contact-form]

Do water ionizers also  remove water contaminants , including fluoride?

This question should be about the water filters used  inside the water ionizers/purifiers. Water ionizers, by themselves, don’t really remove anything from the water. A water ionizer is an electronic device that ionizes water through water electrolysis into ionized  water stremas (alkaline and acidic ).

The question should be regarding water ionizers that include water filters inside them such as AlkaViva water ionizer(manufactured by Jupiter/EmcoTech). AlkaViva’s best water ionizers even include 2 water filters inside the water ionizer/water purifier to filter/remove all the potential contaminants in your water before water is ionized , so that you will enjoy not only ionized alkaline, antioxidant water, but clean yet mineral water as well.Only AlkaViva water ionizers such as AlkaViva Jupiter Athena JS 205 water ionizer & AlkaViva Vesta GL 988 water ionizer include 2 water filters inside the water ionizer /water purifier system. One of these 2 water filters can be a UltraWater Fluoride /Arsenic Shield – a water filter specially designed to remove Fluoride & Arsenic. Our quality Jupiter water ionizers also have water prefilters to prefilter the water before water is ionized. It should be noted that most water filters inside a water ionizer do NOT remove fluoride, because lab testing has shown that fluoride contained in the incoming water happens to “stick” to the acid water stream, and the concentration in the alkaline drinking water side is lessened.  The fluoride is attracted to the positive charge of the acid water, and will be partially eliminated.  But, when we are speaking of fluoride, “partially” is not good enough.  We want to be able to eliminate as much of the fluoride as possible .Why-read more about fluoride in water-click here

What is Ionized Acid Water Acid ionized water can be characterized by the following:

  1. having a pH range between 2.0ph and  lower than 7.0ph
  2. having an ORP of +800 to +1200
  3. having a hypochlorous acid component from 1-30 mg/l
  4. being micro-clustered
  5. being loaded with H+ (hydrogen ions), which acts as an oxidizer

There are 2 types of acid water; mild and strong. ‘Mild’ acid water is used for the skin, hair and nails while ‘strong’ acid water is used for cleaning and sterilizing. Uses Of Ionized Acid Water

How To Get The MOST Acidic ionized Water From Your water Ionizer? Although most water ionizers allow you to choose “acid” ionized water , which would then come out of the top stainless steel hose, there is a way to get the most acidic water from your water ionizer (the lowest pH). Set your water ionizer to the highest “alkaline” ionized water  setting that it will produce.  Then, slow the water flow rate down (either on the faucet or on an onboard flow-control valve, if you have one) to the slowest the water can come out while the water ionizer remains powered on. On most water ionizers with water flow sensors, if you slow the flow rate down too much, the water ionizer will shut itself off – so make sure it is slow, but enough that the main power stays on.  Then, collect the acidic water from the acid hose coming from the bottom of the water ionizer in a (glass) recipeint. Doing it this way will give you the most powerful acid water that your water ionizer can make. The results will vary from water ionizer to water ionizer, depending on the strength of the water ionization unit.

How can I tell what contaminants & other things are my tap water? There is a lot that we can learn about our water just by the way it looks, tastes, and smells. If you are concerned about the quality of your water it is always best to have it professionally tested(contact us of interested in professional water testing ), but we can also discover much about it at home. When using a water ionizer many things in our water can be condensed into higher, more noticeable levels. If you are on a public treated water system you can always ask for a consumer confidence report, or CCR. These are done annually to insure the public of drinking water safety. The easiest way to obtain these reports is to call your local water authority and ask for the most recent CCR.You can also ask them if they are using chloramines as a disinfectant. Chloramines are fairly new in the treatment of water systems in most areas, and may not show up on the report. Chloramines are definitely unwanted, and require a different type of water filtration than the standard chlorine water fitration methods. Although it is a great idea to look at your CCR, you can always take it one step further and have the water at your home tested locally. Keep in mind that the water reports provided are shown in averages and may not reflect exactly what is coming in to your home, so , if you are really interested in what;s in your tap water. it would be a good idea to test the water coming right from your tap If you are on a well water system it is important to test your water before running a water ionizer, as well water is generally untreated and can contain contaminants not present in treated water systems. Testing the water in your well can protect your health, as well as the life of your water ionizer. To obtain a water report you can call your local health authority and express concerns for your drinking water. They will usually have a place locally to do the necessary testing. The test you want to ask for is called “A Routine Domestic Panel,” and doesn’t usually cost an arm and a leg. Water reports will list a bunch of numbers that can be a little confusing, but once you learn to read the report you’ll be able to see exactly what’s in your water. The important numbers to look at will be the levels recorded – this is the amount found in your water – and the MCL, or Max Contaminate Level. In comparing these two sets of numbers you can judge if the levels are safe or should be addressed before using your new water ionizer. If the levels recorded for your water are lower than, or close to, the MCL levels you may want to consider water pre-filtration. You would also want to consider water  pre-filtration anytime you have specific concerns especially in areas with very hard water.Of course, you can always use our AlkaViva Reverse Osmosis System For Water Ionizers to remove the most common water contaminant concerns. We will be covering some basic at-home tests for testing drinking water contaminants, what they are, where they come from and how we can remove them.  There are many things the following tests can tell us, but certainly not everything. For example there is no good way to test at home fluoride, bacteria, arsenic, and many other drinking water contaminants without a professional water test(contact us if interested in a professional water testing). For the contaminates that we CAN test for at home, all you will need is your faucet and a clear glass.

The Way That Water Tastes Chlorine or chemical taste This taste is usually caused by normal chlorination, or an abundance of chemicals in either treated municipal water systems, or chlorinated wells. This is normally removed by your water ionizer internal water filter, but if this is not enough to remove the unpleasant and possibly harmful carcinogens we recommend using our UltraWater ionized water filter

Metallic taste A metallic taste is usually caused by manganese, or other heavy metals. These can be present in well water systems, and older homes with metal pipes. To remove these heavy metals we recommend our UltraWater ionized water filter

Water no longer tastes as sweet as it used to This is caused by the lack of iron present in your source water. Some folks complain that there water no longer taste as sweet as it used to. This is caused by the removal of iron. Although iron is a harmful heavy metal, it adds a pleasant sweet taste to the water. Often, after changing to non metallic pipes or adding a heavy metals pre-filter, the lack of sweetness can be present. Usually after a week or two, it is no longer noticeable.

Water tastes fishy, or earthy The fishy, or earthy taste is generally caused by harmless organic matter and is usually associated with surface water supplies. To remove this we recommend that you regularly change your internal water ionizer filter.

The Way That Water Smells Detergent, or soapy smell Sometimes a septic odor. This is usually an indication that you need to hire a plumber, or call your city water authority. This is caused by the leaking of a sewer system into your water supply, and should be addressed as soon as possible.

Water tastes fishy, or earthy The fishy or earthy smell, again, is generally caused by harmless organic matter and is usually associated with surface water supplies. To remove this we recommend that you regularly change your internal water ionizer filter.

Rotten egg smell from the tap Dissolved hydrogen sulfide gas in the source water, or raw sulfur deposits in a well water situation. Sulfur deposits are naturally occurring, and common in some areas. Dissolved hydrogen sulfide comes as a result of organic matter decomposing in a raw water situation, such as plant matter in a well (think of tree roots). This gas reacts in a water ionizer and can become much more noticeable after ionization, and is condensed into the alkaline stream. To remove this gas we recommend using our UltraWater ionized water filter

Rotten egg odor from hot water only Rotten egg odor from the hot water only is caused by sulfates reacting with magnesium anode rod in your hot water system, which will react to create hydrogen sulfide gas and cause this odor to only be present when using hot water. To remove the rotten egg smell you need to have a plumber replace the anode rod with one made of aluminum.

Chlorine or chemical smell This odor is usually caused normal chlorination, or an abundance of chemicals in either treated municipal water systems, or chlorinated wells. This is normally removed by your water ionizer internal filter, but if this is not enough to remove the unpleasant and possibly harmful carcinogens we recommend using our UltraWater ionized water filter

The Way That Water Looks White stains on cookware and in glasses This is a sign of high alkalinity, which is exactly what we do with our ionizers. Completely harmless and nothing to worry about, but not aesthetically pleasing. An easy way to remove this is too soak in a solution of white vinegar and water. Be sure to rinse all the vinegar off before using.

Suspended stuff in your glass This is caused by sediment. It is common in well water using pumps, and in older homes and neighbor hoods. This can easily removed by your water ionizers internal sediment filter(with ionizers such as AlkaViva Jupiter Athena JS205 water ionizer or AlkaViva Vesta GL 988 water ionizer), or with our External Sediment and Bacteria Reduction Cartridge.(contact us if interested)

Green stains on sinks and fixtures Green stains in your sink or on other household fixtures is caused by acidic water with a pH of 6.8 or lower reacting with brass and copper pipes and fittings. Your best bet is to hire a plumber to update these to a more modern system.

Red or yellowish water If water is clear when first poured but turns yellowish or reddish after 24 hours of standing time, there is un-dissolved iron in your water. If it is yellow or reddish when at first poured but clears up after 24 hours then there is dissolved iron in your source water. Iron is a big concern with water ionizers as it can directly cause damage to your ionizer’s electrolysis system. In either case we would recommend using our UltraWater ionized water filter or with an External water prefilter Cartridge.(contact us if interested)

Black tint to water A black tint to water that clears up after 24 hours of standing is usually dissolved manganese. This is easily removed with our UltraWater ionized water filter or with an External water prefilter Cartridge.(contact us if interested) Blacking, pitting, and tarnishing of metal sinks, pipes, and utensils. The blackening, pitting, and tarnishing of metal sinks, pipes, and utensils is caused by chlorides and sulfates (salts) or hydrogen sulfide gas. Both are removed using our UltraWater ionized water filter or with an External water prefilter Cartridge.(contact us if interested)

Milky water If your water looks milky after ionization don’t worry, this is caused by the ionization process and is a sign of both the high alkalinity and the micro clustering. Micro clustering creates air pockets that can make water look milky. The increase in alkaline minerals can also cause this effect. This list in no way can replace the results of full water work up done in a laboratory environment, but can help to troubleshoot quickly and at no cost. All of the external pre-filters that we provide require a pre-filter housing, and these housings can be run in sequence if there is more than one concern.

Do I have hard or soft water? What’s the difference?

Contact us to find out EXACTLY how hard your water is

Original article by snyderhealth.com

 

water ionizers -user troubleshooting

Water ionizers Trouble shooting

Please check out the following water ionizers troubleshooting suggestions before calling for an water ionizer repair .

Symptom  Possible cause   Resolution 
The display panel of the water ionizer does not light up. Is the power cord plugged in correctly to an active outlet?  *Plug the power cord in properly.
Switch does not work. * Is the power plug connected to the outlet properly? * Is the fuse on the back of the water ionizer blown? * Plug the power cord in properly. * Check the fuse on the back of the water ionizer alkalizer and replace it if necessary.
 Water does not flow out or the water ionizer unit has stopped functioning. * Is the source water valve line closed? * Is the source water line properly connected to the water ionizer? * Is the white water ionizer hose bent? * Is the input water pressure too low? * Is the main water supply turned on or is the line frozen? * Is the water ionizer filter clogged ? * Running the acidic water on Acidic Level 3 for 10+ mins. through the water ionizer? * Turn the water supply valve on. * Be sure the input water ionizer hose is connected properly. * Be sure the input water ionizer hose is not bent. * Replace the water ionizer filter. * If the water ionizer unit is leaking, turn off the water supply valve and contact customer service. * Replace the water ionizer filter. * Turn off the water  ionizer purifier alkalizer machine at the power switch for 5-10 minutes to allow for a reset period then turn the water ionizer and purifier back on.
Water is leaking from one water ionizer hose at the attachment to the water ionizer alkaline water machine * Check to see if the water  ionizer hose is disconnected from the water ionizer alkaline water machine   Connect the water ionizer hose snugly to the attachment to the water ionizer alkaline water machine.
 The ionized water or filtered  water has a strange odor or tastes bad. * Has the water ionizer alkalizer machine been unused for a long time? * Has the drain water ionizer hose been immersed in water?  * Let acidic ionized water flow through thewater ionizer alkalizer machine & water ionizer filters for 3minutes or more. If the water does not improve, replace the water ionizer filter. * Remove the drain water ionizer hose from water
Even though the water ionizer filter has been replaced, the water filter life indicator still shows no-life. * Did you reset the water filter counter?  * Reset the water ionizer filter by pressing the water filter replacement button
There is a strange noise coming from the water ionizer system. * Unknown. * Switch off and stop using the water ionizer system and contact customer service.

Calcium in ionized alkaline water When filling your cup with alkaline ionized water, white flakes are seen floating in the cup. * This large quantity of mineral flakes in the water may occur right after a filter change or first use of the water ionizer alkaline water machine. There is no problem with drinking this ionized alkaline water as it is mostly calcium which is not harmful to consume. When high alkaline ionized water is left in a container, the water will form a white film around the edges or on the bottom. The substance is CaCO2 – bonded calcium, which falls to the bottom of the container. If you prefer to not have this white substance in your water, adjust the water ionizer pH to a lower level which will reduce the possibility of calcium bonding. Calcium flakes form by bonding with molecular hydrogen which is abundant water ionizer gas generated in alkaline ionized water. The presence of calcium is a sign that the water ionizer alkaline water machine is functioning properly. If you would like to clean calcium out of any container, put a spoonful of vinegar in the container and fill it with water. Vinegar will dissolve the calcium. Leave the water in the container for 1 hour and shake the water out.

FEEL FREE TO CONTACT US FOR ANY HELP: +40758638401 Kindest Regards!

Ionized hydrogen water uses(alkaline, neutral, acidic)

water ionizer for home uses ( Alkaline, neutral, acidic )

Drinking alkaline ionized water, Cleaning and washing  with highly alkaline ionized water  rinsing, embalming and disinfecting with acidic ionized water.

  • As explained in this articleWATER IONIZER WORKING PRINCIPLE : ALKALINE IONIZED WATER – WHAT IS IT? –    through a water ionizer purifier and alkalizer machine,  by performing water electrolysis , the input filtered water (that enters the water ionizer chamber and comes in contact with the water ionizer platinum plates ) is split into 2 output streams :

    1.  ionized alkaline water that is also antioxidant due to molecular hydrogen gas dissolved in it via electrolysis ( a water ionizer is a generator of hydrogen in water ) this alkaline ionized water is for drinking (pH <10) or for washing machine / laundry, fruits and vegetables washing , cooking etc – details below

     2 . acid(pH<7) ionized water that is oxidative and is usually used externally for disinfecting wounds, skin, eczema or surfaces as strongly acid ionized water kills bacteria : you can use acid ionized water to rinse hair , clean windows and other surfaces ; details below

A WATER IONIZER PURIFIER AND ALKALIZER MACHINE PRODUCES IN FACT MORE THAN  3 KINDS OF WATER:

    • Alkaline ionized Water (hydrogen water) ( a water ionizer pH levels range from about 7.5 to about 10.5-11 (we obtained above  12 pH with the alkaviva Delphi H2 water ionizer in Tenerife – the best water ionizer on the market!) on the alkaline side . Alkaline ionized water is harder than any other water to store in such a way as to keep the pH / ORP qualities. Therefore An entire page to show you exactly how to store alkaline ionized water well. 
    • Filtered / purified water (not ionized water , usually neutral pH water (it will have the same pH as your source water). For babies and toddlers it’s best to use filtered / purified water which is neither alkaline nor acidic. pH range 7-8. Also, when you are taking medication filtered water is best as alkaline ionized water increases  nutrients and supplements adsorption.
    • Acid ionized water: If you set your water ionizer unit on and Acidic-level, alkaline ionized water [which is drinkable by the way] will come out the bottom water ionizer hose, Otherwise, acid ionized water comes out of the bottom water ionizer hose or spout when you are pouring alkaline ionized water. Acidic ionized water stores very well. You can keep it in an open container, tub, etc. and it will remain the same acidity as when you poured it.

ALKALINE IONIZED WATER USES:

here are a few examples (more will be given at the end of the article):

ionized water for kidney disease/ kidney failure:

  • Does alkaline ionized water from ionizer have any side effects /negative effects ?
  • If the water ionizer pH is lower than 10 there are no water ionizer health risks that we are aware of so far (please read the link above hydrogen water safety – you will also find answers regarding water ionizer benefits,water ionizer research, water ionizer study etc ) .
  • If the water ionizer pH is above 10 please do not drink this ionized alkaline water (at least not for a very long time ; rather use this highly alkaline ionized water for cleaning you laundry / washing machine ,  fruits, vegetables and cooking)
  • Cleaning & Laundry using highly alkaline ionized water:
  • At the highest levels of alkalinity [10.5 – 12 pH] the ionized alkaline water will emulsify oils. This is great for soaking non-organic vegetables in, because soaking in it will help to naturally remove the oily pesticides from the outer layer of the vegetable.
  • High alkaline ionized  water also has another great use as a stain-remover. Some water ionizer consumers report have had success with completely removing chocolate, blood, blue-berry stain, peanut butter, pet-stains and other stains from clothing, carpets, tile-grout, and furniture over the years – use ionized water high alkaline  for laundry in the washing machine( don’t put the water ionizer in the washing machine, just the high alkaline ionized water 🙂 ) .
  • Here are some other ionized water home use ideas for using the highest water ionizer pH water for cleaning [we’ll cover the lowest acid-water later]:
    • You can pour a bowl of the high alkaline and a second one of acidic water… for cleaning fine washables [like stockings, silk skarf, etc.]. When you do this I suggest to let it soak for several minutes in the high alkaline, then agitate and wring-out the garments. Follow this up with a soak in the low acid water, which will act as a germicidal, softener [removing any residual alkaline minerals], and freshen it up.
    • water ionizer for laundry / washing machine : You can pour 2 – 4 gallons of high alkaline ionized water in the washing machine for laundry and not need to use detergent.
    • You can use high alkaline ionized water to clean windows and other greasy areas,  , floors, stoves and countertops.

WHEN TO USE JUST  FILTERED/PURIFIED WATER

  • Medications: A neutral 7.0 – 8.0 pH filtered water is perfect for taking medications. For 20-30 min. before and after taking medications it is suggested to only drink filtered water. The chemical make-up of medications and the predicted rate of absorption into the body can be altered by consuming microclustered, ionized water with them. Rather than take a chance of messing up your doctor’s plans, it’s better to just take the safe route described here.
  • Infants & Todlers: A neutral pH is perfect for babies. Give babies and todlers “filtered” water, not ionized water, until they are about 2 years old. After that, you can slowly introduce them to ionized alkaline water [i.e., over the next 2 – 3 years use level 1, then do the same for level 2, etc.]. At about 9 or 10, a child can drink the same water ionizer pH level as an adult.

ACIDIC IONIZED  WATER [OXIDATIVE IONIZED WATER]

Reverse Aging with Alkaline Water!

Reverse Aging with Alkaline IONIZED Water!

Can Ionized Alkaline Water  stop the aging process and even “reverse aging” or is it just a myth/exaggerated claims?

The article below from AlkaViva website (ex IonWays) is a selection of Mr. Sang Whang, a successful inventor, scientist and engineer.

Sang Whang, Korean American scientist and inventor , explains beautifully in his revolutionary “Reverse Aging”.

He says that water has memory (we saw this amazing crystal images of ionized alkaline water- microstructured snowflake water  , taken with by MRI of Dr. Masaru Emoto and the early works of homoeopaths) but he goes further .Shang Wang says this memory is expressed as measurable electricity. This energy can be measured in volts (or millivolts, because it is always very small) and can be lost over time. When water has an electrical potential has the ability to make the hydrogen to take two different forms.

Article becomes quite technical.

When the ionized water has electric energy, it causes to hydrogen in the take one of two forms. One is hydrogen, which has a positive electric charge. This ionized water is ‘acidic’. The other is hydrogen, with a link of oxygen and becomes negatively charged. This is the block of life itself with the chemical form of OH-.

An oxygen atom plus  a hydrogen atom with negative charge. This is Ionized Alkaline Water. (electric) Ionized water  has energy and is alkaline & can now donate energy & alkalinity to any compatible atom in your body. ionized water rich in OH- ions has a pH> 7 it is called “alkaline”.

 

 

In both forms, these hydroxyl ions OH-, or atoms now have the ability to precipitate the chemical reaction of other minerals in the water. What does it with health and longevity?

It should always be read and water ionization means and why we need negative ions.

Nothing happens in our bodies without a chemical reaction.

And every chemical reaction only happens when “energy” of only two atoms is compatible. So we can say that we are a chemical organism – by courtesy of electricity.

At the molecular level, beyond cell, trillions of rejection and electrical unification happens every millisecond of our lives. It’s a real orgy of unity, and is happening right now in your body always happens and continues to balance acid and alkaline reactions – the battle between them ends up

Who / what wins this battle ion? Acid – every time. We all know that our body acids take control after we die to damage the body. Let me tell you, acids did this many, many years before he died. They do now! Rust, break, break, burn, oxidize – they are all a natural part of our balanced metabolism.

So .. life as we know it is a “struggle” between the internal positively charged atoms (ions) and negatively charged atoms (ions). We just – but less accurately – say life is a battle between acid and alkaline, because that’s exactly what It means your body’s pH.

measuring the pH balance of the alkali / acid

Returning to the water (ionized) – where there are more H + ions than OH-ions in water, ionized acidic water talk. When there are more hydroxyl ions OH-than H +, talk ionized alkaline water.

In short:

Acid or alkali is measured by pH.
pH is a measure of hydrogen ions (atoms).
The more H + ions in water, the more “acidic”.
The more ions OH – in water, the more “alkaline”.
Acidic water and alkaline water can be considered conceptually as electric or hydrogen ion carrying a positive charge or negative electricity.
All chemical processes in your body are initiated and completed when the correct electrical charge is found to match the electrical charge of another atom. Nothing happens without electricity. Electrical and chemical, are therefore the same in the body.

We agree with this?

If not, please assign five precious minutes and reread, because what will come about ionziata alkaline water is based on your understanding so far and is the key to health and anti aging secret Orin Ionized Alkaline Water.

Alright. Ionized water (and beyond) can hydrogen ions in it. An ion is an atom with an electric charge.

We can measure the pH using litmus paper or electronic pH meter. This will give a reading of 0-14, with pH 7 being neutral; or acid or alkali. Or we can use an ORP meter that tells us more. We say A = R = reduction or oxidation of the donation, P = potential of a liquid. That’s what O.R.P. înseamnă.POTENTIAL reduce oxidation

Oxidizing means the ability to oxidize. To burn and produce energy but to destroy, “rust” breaks. “That is oxidation (happens to our bodies after death).

However, oxygen is also necessary for life and the life-processes of living beings. We can not live and can not be healthy without oxygen.

Ionized water oxygenates the body by increasing the ratio of oxygen / hydrogen. Why? Easy-water H20 has one oxygen atom for every two hydrogen atoms. Ionized alkaline, rich in hydroxyl ion (OH-) has an oxygen atom for a hydrogen atom.

All other waters are deprived of this benefit. Implications of this are multiple health, energy and vitality

Ionized water oxygenates your body more effectively than any other treatment “Oxygen” / ozone therapy.

At the same time, measures are needed to prevent and combat the damage caused by oxidation processes-those antioxidants-ORP

The reduction is not as easy to understand. Scientifically, it is giving away, or to donate, so if a liquid “reduce oxidation potential”, he has the ability to donate energy to the body.

Alkaline water has millions of hydroxyl ions per bottle and provides a powerful antioxidant, numti-ORP. No other water has that incredible advantage. Hydroxyl ions help to “neutralize” free radicals that cause cellular damage / oxidative stress and premature cell aging,

Alkaline water eliminates and fights free radical damage – the body more effectively than vitamin C consumption bottles!

 

is what we say and Dr. Robert F. McCauley, Sr. about the antioxidant power conferred by hydroxyl ions (OH-) in alkaline ionized water and stopping and reversing the aging process

Oxygen derived from the ionized form to the body reaches a very powerful antioxidant, which has attached to it an extra electron, and it is known that the hydroxyl ion (OH-).
It occurs when water is carried over positive and negative electrodes and there is a shift of electrons from one molecule to another.
The hydroxyl ions have an oxygen molecule that carries an extra electron is donated to free radical in the body (see Appendix 4), so it is considered as a street sweeper “” of free radicals.
What remains are two stable oxygen molecules and a higher level of oxygen in the blood (which will ajutasi of the immune system) instead of one that will cause free radical damage.
Drinking ionized water inside your body bathes in a negatively charged liquid, which promotes rejuvenation of each bodily system at a cellular level.
All fresh raw foods also have a negative charge and ORP.
Freshly squeezed orange juice carries a negative ORP -50 to 300 ORP (mμ).
The smaller the negative number, the better it is for the body; higher the positive number, the worse it is.
On average, chlorinated city water has a positive ORP +700 so pretty oxide and should not be consumed.
Anything that is oxidized, or has the potential to oxidize another substance, has a positive ORP.
Our bodies are constantly attacked by the oxidation radicals in the form of; how much older we are, the need for higher negative ORP.
When we drink negatively charged substances such as Ionized Water, this oxidation is retarded and our body cells are in a better position to rejuvenate, or reduce, their age.
Water has a low atomic weight (18) and when water is ionized through electrolysis, it becomes the most absorbent and antioxidant known.
In essence, reversing the aging process. However, we do not become younger in chronological years, 40 years if we do not we become 20 again. Rather, we hold nivelcelular body in 20 years.
This means that the cells that make up my body are as active, productive, communicative and functional as those of 20 years and potentially even better.
So I reversed my biological clock, not chronologically. ”
More on electrical charge alkaline ionized water that gives benefits and unique properties and implications for the optimal functioning of the organism and living beings.

Alkaline water is super conductive properties. ONLY ionized water has an electrical charge that gives vitality water

Alkaline water is living water.

What is / about living water?

All electrons in water are either spin / rotation left or right. The higher the spin speed the more water left electrons is considered to support the vitality, the living water. Only Alkaline ionized water has this quality.

Did you know that filtering devices-ionization (alkalizing) AlkaViva water were tested in the laboratory to what extent vdea vitality water load (how much life force once the water gets through them), and bought with other waters considered to be living including Kangen Water?

Here’s what the tests revealed water vitality, made in Alberta Canada, click here.

Filtering devices-ionization (alkylation) generating water AlkaViva are true living water, as shown in tests, not words without coverage.

“Alkaline living water is regarded by a number of health professionals as the best water to drink and is listed as a medical device in Japan for the treatment of degenerative diseases.” Dr Hidemitsu Hayashi heart surgeon, Director of the Water Institute of Japaniei

And the water is more alive and more asemantoare living in properties with natural waters as found in the valleys of longevity (we studied) than AlkaViva living water?

Alkaline water is the only water that has a low surface tension. The surface tension is measured in dynes (s). This allows for greater absorption of water and with water of nutrients in the body.

 

Alkaline water has positive polarity.

Almost all other waters are negative polarity. ONLY positive polarity water can effectively help remove toxins and poisons from the body at the cellular level. Alkaline water can help flush toxins and poisons from your body better and with much less negative effects than any other detox program / protocol.

Alkaline water is very positively perceived by the organism and living beings. This allows the cells to efficiently transmit photons with each other. This function allows the production of vital inter-cellular communication.

Alkaline water is a thousand times healthier for your body than any other water. And proof “is in the pudding,” so to speak. Everyone drinking ionized water or milk in its natural state as glacier / glacier milk, or a quality water ionizer (built with quality materials and parts is that ionizes does birth and not overly optimized) lives in health status “light years” from those who do not.

Did you know that 15% of the population of Japan, drinking alkaline water from water ionizers have a life expectancy of 10 years, in addition, more than those in the United States? And drink ionized water for an average of only 12 years! Think if that would be started drinking ionized water from birth!
A glass of ionized water can hydrate the body better than gallons of any water.
Let’s face it; comes a time in our lives when we want some people to be estimated us / “guessed” our age a bit lower than they facuto. Instead of looking for new pills or injections that can take to lessen the aging process, maybe it is time to look at other issues at hand with greater impact related to the lifestyle and the things introduce in our body.

 

Here are some selections that may be of interest to anyone wondering about how it affects an alkaline diet.

“We were born at the high alkaline blood pH 7.44. As we get older, the blood pH drops to 7.35 or below. Blood pH referred to here is the artery pH Blood. difference of 0.09 pH seems very small, but because the pH is a logarithmic, an amount of hydroxyl ion (OH-) at pH 7.44 is 1.23 times higher than pH 7.35, as 10 = 1.2303. ”

“In some extreme cases, the accumulation of acidic elements are so great that begin to destroy healthy cells around them. Healthy cells must maintain a slightly alkaline pH level. Some cells change their metabolism and functions in order to survive in an acid environment. This is the start of cancer. are acidic in cancer cells while normal cells are alkaline. Although the cancerous tumors are removed surgically or completely destroyed by other means (chemotherapy, radiation but only alternative anti-tumor) as long as they remain under the acidic conditions in the area, chances are that new tumors will develop around aceeleaşi areas.

Exactly where waste accumulates may vary depending on each individual. However, parts of the body where waste accumulates can determine what kind of disease a person may develop in the first place. ”

“Because the accumulation of waste within the body and dauunele caused by free radicals / oxidative damage are strongly correlated with the aging process, helping the body to prevent damage and escape of waste ixidare old the anti-aging process.”

Sang Whang, in his book “Reverse Aging” / “Rejuvenation”

“In general, degenerative diseases are the result of the accumulation of acid waste in the tissues. When we are born, we have the highest concentration of alkali and also body pH is higher. Since that time, the normal process of life is to gradually acidify. That is why these degenerative diseases do not occur when they are very young.

“Rejuvenation” requires two distinct phases: chemical and physical

The first step is to reduce the acidity of the body so as to eliminate acid waste in the blood and cellular fluids safely and easily.

The second step is to remove all of the old waste deposited in the blood stream so that they can be discharged from the body. ”

 

NOTE:

 Alkaline ionized water is highly alkaline pH.

It may be from 100 to thousand times more alkaline than all of the other waters. (PH is a logaritmic scale / measure . The difference between pH 7 and pH 8 is exponential) Alkaline water removes acidosis / over-acidity in the body, the environment installs all diseases and the cause of most diseases (including cancer , heart disease, liver disease, kidney disease, bone and joint diseases, infectious diseases and many others)

“Ionized alkaline water body better than any other method (diet 100% organic vegan / organic).” Blake Sawyer

Shang Wang endorses  AlkaViva (ex IonWays) / EmcoTech (ex Jupiter) water ionizers becoause ionized water of a quality (such as those AlkaViva) offers a powerful antioxidant and a powerful detoxifier that prevents and reverses cell imbatranierea but for ionziata water a water ionizer AlkaViva acquire properties and unique benefits that no other water today does not have

Properties and unique benefits AlkaViva ionized water (mineral water no contaminants, alkaline water with an alkaline pH EXTREME (100 thousand times more alkaline than any other water), active oxygen-rich water, water with millions of hydroxyl ions per glass and water that provides a powerful antioxidant called ORP. (no other water does not have this incredible advantage), structured water with hydrogen bonds, molecular structured water in groups / clusters water 4-6 H20 molecules, water hexagonal form (water snowflake) Virginia Water – water “PURE” (EMF electromagnetic water whose memory was reset to zero) living water (alkaline ionized water only has this quality) super conductive properties of water, water has a low surface tension, water positive polarity, etc.) explained click here
Ionized alkaline water of life and health-click
Doctors and experts admit INTERNATIONAL TALK-click here
SCIENTIFIC STUDIES ionized water, click here
CLINICAL TESTS ionized water, click here
What to Expect from ionized-click
Ionized Alkaline Water Video here