Benefici / effetti dell’idrogeno molecolare (acqua) in modelli patologici, malattie umane, patologie associate al trattamento e condizioni patofisiologiche delle piante

L’idrogeno molecolare (acqua) è efficace essenzialmente in TUTTI gli organi, così come nelle piante.

Abbiamo ora classificato gli organi e le malattie in 31 categorie e mostrato gli effetti dell’idrogeno molecolare in 166 modelli di malattia, malattie umane, patologie associate al trattamento e condizioni patofisiologiche delle piante.

La tabella 2 mostra i dettagli di organi e malattie per i quali sono stati riportati gli effetti dell’idrogeno molecolare.

La tabella 2 collega gli effetti e i benefici dell’idrogeno molecolare alle MALATTIE E CONDIZIONI e agli studi corrispondenti:

ORGANI E MALATTIE COPERTI	MALATTIE E CONDIZIONI E BENEFICI DELL’IDROGENO MOLECOLARE	RIFERIMENTI: STUDI SU IMPIANTI, ANIMALI E UMANI E STUDI CLINICI SUI BENEFICI DELL’IDROGENO MOLECOLARE
Cervello e idrogeno molecolare, malattie cerebrovascolari (CVD) e idrogeno molecolare, lesione I / R cerebrale e idrogeno molecolare, ictus ipertensivo e idrogeno molecolare, lesione cerebrale secondaria a emorragia intracerebrale e idrogeno molecolare, emorragia subaracnoidea e idrogeno molecolare, lesione cerebrale diversa dalla CVD e idrogeno molecolare, lesione cerebrale traumatica e idrogeno molecolare, danno cerebrale indotto da arresto circolatorio ipotermico profondo e idrogeno molecolare, malattie neurodegenerative e idrogeno molecolare Morbo di Parkinson e idrogeno molecolare, morbo di Alzheimer e idrogeno molecolare, altre condizioni di salute del cervello e idrogeno molecolare, ritenuta- demenza indotta e idrogeno molecolare, demenza senile in topi con accelerazione di senescenza e idrogeno molecolare, neuroinfiammazione indotta da LPS e idrogeno molecolare, danno neuronale indotto dallo stress ossidativo e idrogeno molecolare, midollo spinale e nervo periferico e idrogeno molecolare, midollo spinale I / Lesioni R e idrogeno molecolare, midollo spinale D lesioni e idrogeno molecolare, dolore neuropatico e idrogeno molecolare, iperalgesia e idrogeno molecolare, occhi e idrogeno molecolare Lesioni retiniche I / R e idrogeno molecolare, retinopatia diabetica e idrogeno molecolare, retinopatia indotta da iperossia e idrogeno molecolare, retinopatia indotta da luce e molecolare idrogeno, retinopatia indotta dalla glutammina e idrogeno molecolare, retinopatia indotta da S-nitroso-N-acetilpenicillamina e idrogeno molecolare, schiacciamento del nervo ottico e idrogeno molecolare, cataratta indotta da selenite e idrogeno molecolare, bruciore di alcali corneale e idrogeno molecolare, antinfiammatorio effetti su cellule di microglia retinica attivate da LPS e idrogeno molecolare, orecchie e idrogeno molecolare Perdita dell’udito e idrogeno molecolare, ototossicità indotta da cisplatino e idrogeno molecolare, ototossicità indotta da Ouabain e idrogeno molecolare, cavità orale e idrogeno molecolare Parodontite e idrogeno molecolare, Ossidazione periodontale danno e idrogeno molecolare, polmoni e idrogeno molecolare, polmone I / R in giuria e idrogeno molecolare, danno polmonare indotto da ossigeno e idrogeno molecolare, danno polmonare indotto da ventilazione e idrogeno molecolare, danno polmonare acuto indotto da LPS e idrogeno molecolare, danno polmonare intestinale indotto da I / R e idrogeno molecolare, danno polmonare indotto da ustioni e idrogeno molecolare, lesioni polmonari indotte dal paraquat e idrogeno molecolare, lesioni polmonari da fumo di sigaretta e idrogeno molecolare, lesioni polmonari da inalazione di fumo e idrogeno molecolare, ipertensione polmonare e idrogeno molecolare, cuore e idrogeno molecolare Infarto miocardico e lesioni I / R e idrogeno molecolare, Cardiomiopatia diabetica e idrogeno molecolare, rimodellamento ventricolare sinistro indotto da apnea del sonno e idrogeno molecolare, ipertrofia ventricolare e idrogeno molecolare, stomaco e idrogeno molecolare Ulcera gastrica indotta da stress e idrogeno molecolare, Ulcera gastrica indotta da aspirina e idrogeno molecolare, Intestino e idrogeno molecolare Lesioni I / R e idrogeno molecolare, colite ulcerosa e idroge molecolare n, Infiammazione del colon e idrogeno molecolare, lesione intestinale indotta da sepsi e idrogeno molecolare, enterocolite necrotizzante e idrogeno molecolare, fegato e idrogeno molecolare Fegato I / R e idrogeno molecolare, epatite cronica B e idrogeno molecolare, steatoepatite non alcolica e idrogeno molecolare, danno epatico da epatectomia massiccia e idrogeno molecolare, danno epatico indotto da ittero ostruttivo e idrogeno molecolare, danno epatico indotto da endotossina e idrogeno molecolare, danno epatico indotto da acetaminofene e idrogeno molecolare, danno epatico indotto da tetracloruro di carbonio e idrogeno molecolare, danno epatico indotto da concanavalin A e idrogeno molecolare, cirrosi epatica e idrogeno molecolare, fibrosi epatica e idrogeno molecolare, pancreas e idrogeno molecolare Pancreatite acuta e idrogeno molecolare, peritoneo e idrogeno molecolare Peritonite acuta e idrogeno molecolare, benefici molecolari di idrogeno per lesioni renali I / R e idrogeno molecolare , Renale acuto lesione e idrogeno molecolare, lesione renale ipertensiva e idrogeno molecolare, nefropatia indotta da cisplatino e idrogeno molecolare, nefrotossicità indotta da gentamicina e idrogeno molecolare, inibizione della produzione di AGE e idrogeno molecolare, deposizione di calcio renale e idrogeno molecolare, benefici dell’idrogeno molecolare per la cistite interstiziale della vescica e idrogeno molecolare, benefici dell’idrogeno molecolare per gli organi riproduttivi Lesione testuale dell’I / R e idrogeno molecolare, disfunzioni erettili e idrogeno molecolare, stress ossidativo testicolare indotto dalla nicotina e idrogeno molecolare, danno testicolare indotto dal fumo di sigaretta, pelle / idrogeno molecolare I / R lesioni e idrogeno molecolare, lesioni cutanee indotte da UV e idrogeno molecolare, malattia della pelle eritematosa acuta e idrogeno molecolare, dermatite atopica e idrogeno molecolare, psoriasi e idrogeno molecolare, ulcera da pressione e idrogeno molecolare, ustioni e idrogeno molecolare, tossicità arsenica e idrogeno molecolare, Ossa e articolazioni e idro molecolare artrite reumatoide genica e idrogeno molecolare, osteoporosi e idrogeno molecolare, perdita ossea indotta da microgravità e idrogeno molecolare, lesione osteoblastica indotta da TNFα e idrogeno molecolare, tossicità della cartilagine indotta da NO e idrogeno molecolare, benefici molecolari dell’idrogeno per i muscoli scheletrici sabbia i tessuti molli I / Lesioni muscolari scheletriche e idrogeno molecolare, miopatie infiammatorie e mitocondriali e idrogeno molecolare, affaticamento muscolare e idrogeno molecolare, lesione dei tessuti molli legata allo sport e idrogeno molecolare, benefici dell’idrogeno molecolare per aterosclerosi e idrogeno molecolare dei vasi sanguigni, danni ai vasi sanguigni indotti da AGE e idrogeno molecolare, iperplasia neointimale e idrogeno molecolare, iperplasia nell’innesto venoso arterioso e idrogeno molecolare, disfunzione vascolare e idrogeno molecolare, funzione endoteliale vascolare e idrogeno molecolare, midollo osseo e del sangue e idrogeno molecolare Anemia aplastica e idrogeno molecolare, mantenimento dello stroma / mesenchima multipotenziale cellule staminali mal e idrogeno molecolare, funzione dei neutrofili e idrogeno molecolare, inibizione dell’aggregazione piastrinica indotta dal collagene e idrogeno molecolare, miglioramento della fluidità del sangue e dell’idrogeno molecolare, metabolismo e idrogeno molecolare, diabete mellito e idrogeno molecolare, iperlipidemia e idrogeno molecolare, sindrome metabolica e idrogeno molecolare, espressione genica correlata al processo metabolico e idrogeno molecolare, tossicità cellulare ossidata a bassa densità indotta da lipoproteine e idrogeno molecolare, alcalinizzazione sierica e idrogeno molecolare, acidosi metabolica indotta dall’esercizio e idrogeno molecolare, infiammazione / allergia e idrogeno molecolare sepsi e idrogeno molecolare , Produzione di NO indotta da LPS / IFNγ e idrogeno molecolare, risposta infiammatoria indotta da LPS e idrogeno molecolare, permeabilità vascolare indotta da LPS e idrogeno molecolare, infiammazione indotta da Zymosan e idrogeno molecolare, edema della zampa indotto da Carrageenan e idrogeno molecolare, risposta infiammatoria del cardiopolmonare bypass e molecolare h ydrogen, allergia di tipo I e idrogeno molecolare, asma e idrogeno molecolare, disturbi perinatali e idrogeno molecolare, ipossia cerebrale neonatale e idrogeno molecolare, lesione polmonare fetale indotta da LPS e idrogeno molecolare, preeclampsia e idrogeno molecolare, cancro e idrogeno molecolare, crescita del carcinoma della lingua cellule e idrogeno molecolare, nefrotossicità indotta da Fe-NTA e progressione tumorale e idrogeno molecolare, linfoma timico indotto da radiazioni e idrogeno molecolare, angiogenesi tumorale e idrogeno molecolare, potenziamento dell’efficacia antitumorale 5-FU e idrogeno molecolare, radiazione e idrogeno molecolare idrogeno molecolare, danno polmonare e idrogeno molecolare, danno testicolare e idrogeno molecolare, danno cutaneo e idrogeno molecolare, germe ematopoietiche e altri danni cellulari e idrogeno molecolare, effetti avversi indotti da radiazioni e idrogeno molecolare, disfunzione immunitaria indotta da radiazioni e idrogeno molecolare, intossicazione & idrogeno molecolare Monossido di carbonio INTOSSICAZIONE e talpa idrogeno colare, intossicazione da sevoflurano e idrogeno molecolare, insufficienza cardiaca indotta dalla doxorubicina e idrogeno molecolare, calcoli urinari indotti dalla melamina e idrogeno molecolare, neurotossicità indotta da clorpifrifos e idrogeno molecolare, idrogeno molecolare per trapianto di cuore e idrogeno molecolare, trapianto polmonare e idrogeno molecolare Trapianto renale e idrogeno molecolare, trapianto di intestino e idrogeno molecolare, trapianto di pancreas e idrogeno molecolare, innesti osteocondrali e idrogeno molecolare, GVHD acuto e idrogeno molecolare, rianimazione e idrogeno molecolare, arresto cardiaco e idrogeno molecolare, shock emorragico e idrogeno molecolare, dialisi e molecolare idrogeno Emodialisi e idrogeno molecolare, dialisi peritoneale e idrogeno molecolare, altre condizioni di salute e idrogeno molecolare, estensione della durata della vita e idrogeno molecolare, motilità degli spermatozoi e idrogeno molecolare, malattia da decompressione e idrogeno molecolare, genotossicità e mutagenicità e idrogeno molecolare rogen, Piante e idrogeno molecolare, Organogenesi di radici e idrogeno molecolare, Tolleranza salina e idrogeno molecolare, Maturazione post-raccolta e idrogeno molecolare, Chiusura stomatica e idrogeno molecolare, Tolleranza ai germogli di ravanello a UVA e idrogeno molecolare, Stress ad alta luce e idrogeno molecolare, Segnalazione di fitormoni e risposte allo stress e idrogeno molecolare, tolleranza allo stress ossidativo indotto dal paraquat e idrogeno molecolare, tossicità da cadmio e idrogeno molecolare, tossicità da mercurio e idrogeno molecolare	Cervello e idrogeno molecolare
	Malattie cerebrovascolari (CVD) e idrogeno molecolare
	Lesione cerebrale I / R e idrogeno molecolare	[ 1 , 10 , 56 , 83 , 94 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ]
	Ictus ipertensivo e idrogeno molecolare	[ 110 ]
	Lesione cerebrale secondaria a emorragia intracerebrale e idrogeno molecolare	[ 28 ]
	Emorragia subaracnoidea e idrogeno molecolare	[ 48 , 61 , 66 , 73 , 111 , 112 , 113 ]
	Lesioni cerebrali diverse da CVD e idrogeno molecolare
	Lesione cerebrale traumatica e idrogeno molecolare	[ 114 , 115 , 116 , 117 , 118 ]
	Danno cerebrale indotto da arresto circolatorio ipotermico profondo e idrogeno molecolare	[ 57 ]
	Malattie neurodegenerative e idrogeno molecolare
	Morbo di Parkinson e idrogeno molecolare	[ 11 , 95 , 96 , 97 , 119 ]
	Morbo di Alzheimer e idrogeno molecolare	[ 43 , 120 ]
	Altre condizioni di salute del cervello e idrogeno molecolare
	Demenza indotta da ritenuta e idrogeno molecolare	[ 121 ]
	Demenza senile in topi con accelerazione di senescenza e idrogeno molecolare	[ 122 ]
	Neuroinfiammazione indotta da LPS e idrogeno molecolare	[ 81 , 123 ]
	Danno cellulare neuronale indotto da stress ossidativo e idrogeno molecolare	[ 124 , 125 ]
	Midollo spinale e nervo periferico e idrogeno molecolare
	Lesioni I / R del midollo spinale e idrogeno molecolare	[ 126 , 127 ]
	Lesione del midollo spinale e idrogeno molecolare	[ 77 , 128 ]
	Dolore neuropatico e idrogeno molecolare	[ 39 , 92 , 129 , 130 ]
	Iperalgesia e idrogeno molecolare	[ 79 , 131 , 132 ]
	Occhi e idrogeno molecolare
	Lesioni della I / R della retina e idrogeno molecolare	[ 133 , 134 ]
	Retinopatia diabetica e idrogeno molecolare	[ 135 , 136 ]
	Retinopatia indotta da iperossia e idrogeno molecolare	[ 137 ]
	Retinopatia indotta dalla luce e idrogeno molecolare	[ 138 , 139 ]
	Retinopatia indotta da glutammina e idrogeno molecolare	[ 50 ]
	Retinopatia indotta da S-nitroso-N-acetilpenicillamina e idrogeno molecolare	[ 140 ]
	Schiacciamento del nervo ottico e idrogeno molecolare	[ 141 ]
	Cataratta indotta da selenite e idrogeno molecolare	[ 142 ]
	Brucia alcali corneale e idrogeno molecolare	[ 55 ]
	Effetti anti-infiammatori sulle cellule della microglia retinica attivate da LPS e sull’idrogeno molecolare	[ 64 ]
	Orecchie e idrogeno molecolare
	Perdita dell’udito e idrogeno molecolare	[ 143 , 144 , 145 , 146 , 147 , 148 ]
	Ototossicità indotta da cisplatino e idrogeno molecolare	[ 149 , 150 ]
	Ototossicità indotta da Ouabain e idrogeno molecolare	[ 151 ]
	Cavità orale e idrogeno molecolare
	Parodontite e idrogeno molecolare	[ 32 ]
	r Danno ossidativo parodontale e idrogeno molecolare	[ 152 ]
	Polmoni e idrogeno molecolare
	Lesioni polmonari I / R e idrogeno molecolare	[ 153 , 154 ]
	Lesione polmonare indotta da ossigeno e idrogeno molecolare	[ 82 , 155 , 156 ]
	Lesione polmonare indotta dalla ventilazione e idrogeno molecolare	[ 53 , 157 ]
	Lesione polmonare acuta indotta da LPS e idrogeno molecolare	[ 13 , 14 , 16 , 158 ]
	Lesione polmonare indotta da I / R intestinale e idrogeno molecolare	[ 159 ]
	Lesione polmonare indotta da ustioni e idrogeno molecolare	[ 160 ]
	Lesioni polmonari indotte dal paraquat e idrogeno molecolare	[ 161 , 162 ]
	lesioni polmonari da fumo di sigaretta e idrogeno molecolare	[ 163 ]
	Danno polmonare da inalazione di fumo e idrogeno molecolare	[ 74 ]
	Ipertensione polmonare e idrogeno molecolare	[ 78 , 164 ]
	Cuore e idrogeno molecolare
	Infarto miocardico e lesioni I / R e idrogeno molecolare	[ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 84 ]
	Cardiomiopatia diabetica e idrogeno molecolare	[ 40 ]
	Rimodellamento ventricolare sinistro indotto dall’apnea notturna e idrogeno molecolare	[ 165 , 166 ]
	Ipertrofia ventricolare e idrogeno molecolare	[ 167 ]
	Stomaco e idrogeno molecolare
	Ulcerazione gastrica indotta da stress e idrogeno molecolare	[ 38 ]
	Ulcerazione gastrica indotta dall’aspirina e idrogeno molecolare	[ 168 , 169 ]
	Intestino e idrogeno molecolare
	Lesioni intestinali I / R e idrogeno molecolare	[ 170 , 171 ]
	Colite ulcerosa e idrogeno molecolare	[ 172 , 173 ]
	Infiammazione del colon e idrogeno molecolare	[ 174 ]
	Lesioni intestinali indotte da sepsi e idrogeno molecolare	[ 87 ]
Enterocolite necrotizzante e idrogeno molecolare	[ 175 ]
Fegato e idrogeno molecolare
Lesione del fegato I / R e idrogeno molecolare	[ 71 , 98 , 176 , 177 , 178 ]
Epatite cronica B e idrogeno molecolare	[ 179 ]
Steatoepatite non alcolica e idrogeno molecolare	[ 180 ]
Lesione epatica indotta da epatectomia massiccia e idrogeno molecolare	[ 67 , 93 , 181 ]
Lesione epatica indotta da ittero ostruttivo e idrogeno molecolare	[ 31 ]
Lesione epatica indotta da endotossina e idrogeno molecolare	[ 35 ]
Lesione epatica indotta da paracetamolo e idrogeno molecolare	[ 47 ]
Lesione epatica indotta da tetracloruro di carbonio e idrogeno molecolare	[ 42 ]
Lesione epatica indotta da concanavalin A e idrogeno molecolare	[ 182 ]
Cirrosi epatica e idrogeno molecolare	[ 183 ]
Fibrosi epatica e idrogeno molecolare	[ 184 ]
Pancreas e idrogeno molecolare
Pancreatite acuta e idrogeno molecolare	[ 76 , 185 , 186 , 187 ]
Peritoneo e idrogeno molecolare
Peritonite acuta e idrogeno molecolare	[ 68 ]
benefici dell’idrogeno molecolare per i reni
Lesione I / R renale e idrogeno molecolare	[ 188 , 189 , 190 ]
Lesioni renali acute e idrogeno molecolare	[ 37 , 72 , 191 , 192 , 193 , 194 ]
Lesione renale ipertensiva e idrogeno molecolare	[ 69 ]
Nefropatia indotta da cisplatino e idrogeno molecolare	[ 195 , 196 , 197 ]
Nefrotossicità indotta dalla gentamicina e idrogeno molecolare	[ 198 ]
Inibizione della produzione di AGE e idrogeno molecolare	[ 199 ]
Deposizione renale di calcio e idrogeno molecolare	[ 200 ]
benefici dell’idrogeno molecolare per la vescica
Cistite interstiziale e idrogeno molecolare	[ 201 ]
benefici dell’idrogeno molecolare per gli organi riproduttivi
Lesione testicolare dell’I / R e idrogeno molecolare	[ 202 , 203 ]
Disfunzioni erettili e idrogeno molecolare	[ 204 ]
Stress ossidativo testicolare indotto dalla nicotina e idrogeno molecolare	[ 205 ]
Danno testicolare indotto dal fumo di sigaretta	[ 206 ]
Pelle e idrogeno molecolare
lesioni I / R della pelle e idrogeno molecolare	[ 46 , 207 ]
Lesioni cutanee indotte da raggi UV e idrogeno molecolare	[ 45 , 208 , 209 , 210 , 211 ]
] Malattia della pelle eritematosa acuta e idrogeno molecolare	[ 212 ]
Dermatite atopica e idrogeno molecolare	[ 213 , 214 ]
Psoriasi e idrogeno molecolare	[ 215 ]
Ulcera da pressione e idrogeno molecolare	[ 216 ]
Ustioni e idrogeno molecolare	[ 49 , 70 ]
Tossicità da arsenico e idrogeno molecolare	[ 217 ]
Ossa e articolazioni e idrogeno molecolare
Artrite reumatoide e idrogeno molecolare	[ 218 , 219 ]
Osteoporosi e idrogeno molecolare	[ 36 , 62 ]
Perdita ossea indotta da microgravità e idrogeno molecolare	[ 34 ]
Lesione da osteoblasti indotta da TNFα e idrogeno molecolare	[ 220 ]
Tossicità per cartilagine indotta da NO e idrogeno molecolare	[ 221 ]
benefici dell’idrogeno molecolare per i muscoli molli della sabbia dei muscoli scheletrici
Lesione I / R nel muscolo scheletrico e idrogeno molecolare	[ 222 ]
Miopatie infiammatorie e mitocondriali e idrogeno molecolare	[ 223 ]
Affaticamento muscolare e idrogeno molecolare	[ 224 ]
Lesioni dei tessuti molli legate allo sport e idrogeno molecolare	[ 225 ]
benefici dell’idrogeno molecolare per i vasi sanguigni
Aterosclerosi e idrogeno molecolare	[ 58 , 59 , 85 , 226 , 227 ]
Danni ai vasi sanguigni indotti dagli AGE e idrogeno molecolare	[ 228 ]
Iperplasia neointimale e idrogeno molecolare	[ 29 ]
Iperplasia nell’innesto venoso arterioso e idrogeno molecolare	[ 229 ]
Disfunzione vascolare e idrogeno molecolare	[ 60 ]
Funzione endoteliale vascolare e idrogeno molecolare	[ 230 ]
Midollo osseo e del sangue e idrogeno molecolare
Anemia aplastica e idrogeno molecolare	[ 231 ]
Mantenimento di stroma multipotenziale / cellule staminali mesenchimali e idrogeno molecolare	[ 232 ]
Funzione neutrofila e idrogeno molecolare	[ 233 ]
Inibizione dell’aggregazione piastrinica indotta dal collagene e idrogeno molecolare	[ 234 ]
Miglioramento della fluidità del sangue e dell’idrogeno molecolare	[ 235 ]
Metabolismo e idrogeno molecolare
Diabete mellito e idrogeno molecolare	[ 236 , 237 , 238 , 239 , 240 , 241 ]
Iperlipidemia e idrogeno molecolare	[ 44 , 242 , 243 , 244 ]
Sindrome metabolica e idrogeno molecolare	[ 245 , 246 , 247 ]
Espressione genica correlata al processo metabolico e idrogeno molecolare	[ 248 ]
Tossicità cellulare ossidata a bassa densità indotta da lipoproteine e idrogeno molecolare	[ 54 ]
Alcalinizzazione sierica e idrogeno molecolare	[ 249 ]
Acidosi metabolica indotta dall’esercizio fisico e idrogeno molecolare	[ 250 ]
Infiammazione / allergia e idrogeno molecolare
Sepsi e idrogeno molecolare	[ 41 , 86 , 251 , 252 , 253 , 254 , 255 ]
Produzione di NO indotta da LPS / IFNγ e idrogeno molecolare	[ 27 ]
Risposta infiammatoria indotta da LPS e idrogeno molecolare	[ 90 ]
Permeabilità vascolare indotta da LPS e idrogeno molecolare	[ 80 , 256 ]
Infiammazione indotta da zymosan e idrogeno molecolare	[ 257 ]
Edema della zampa indotto da carragenina e idrogeno molecolare	[ 258 ]
Risposta infiammatoria di bypass cardiopolmonare e idrogeno molecolare	[ 259 ]
Allergia di tipo I e idrogeno molecolare	[ 26 ]
Asma e idrogeno molecolare	[ 63 ]
Disturbi perinatali e idrogeno molecolare
Ipossia cerebrale neonatale e idrogeno molecolare	[ 260 , 261 , 262 , 263 ]
Lesione polmonare fetale indotta da LPS e idrogeno molecolare	[ 15 ]
Preeclampsia e idrogeno molecolare	[ 264 , 265 ]
Cancro e idrogeno molecolare
Crescita delle cellule di carcinoma della lingua e idrogeno molecolare	[ 266 ]
Nefrotossicità indotta da Fe-NTA e progressione del tumore e idrogeno molecolare	[ 65 ]
Linfoma timico indotto da radiazioni e idrogeno molecolare	[ 267 ]
Angiogenesi tumorale e idrogeno molecolare	[ 268 ]
Potenziamento dell’efficacia antitumorale 5-FU e idrogeno molecolare	[ 269 ]
Radiazioni e idrogeno molecolare
Danno cardiaco e idrogeno molecolare	[ 270 ]
Danno polmonare e idrogeno molecolare	[ 271 ]
Danno ai testicoli e idrogeno molecolare	[ 272 ]
Danno cutaneo e idrogeno molecolare	[ 273 , 274 ]
Germe, ematopoietici e altri danni cellulari e idrogeno molecolare	[ 275 , 276 , 277 , 278 , 279 , 280 ]
Effetti collaterali indotti dalle radiazioni e idrogeno molecolare	[ 281 ]
Disfunzione immunitaria indotta da radiazioni e idrogeno molecolare	[ 282 ]
Intossicazione e idrogeno molecolare
INTOSSICAZIONE di monossido di carbonio e idrogeno molecolare	[ 283 , 284 , 285 , 286 ]
Intossicazione da sevoflurano e idrogeno molecolare	[ 287 , 288 ]
Insufficienza cardiaca indotta da doxorubicina e idrogeno molecolare	[ 289 ]
Pietra urinaria indotta dalla melamina e idrogeno molecolare	[ 290 ]
Neurotossicità indotta da clorpifrifos e idrogeno molecolare	[ 291 ]
idrogeno molecolare per trapianti
Trapianto cardiaco e idrogeno molecolare	[ 52 , 292 , 293 , 294 ]
Trapianto polmonare e idrogeno molecolare	[ 33 , 88 , 295 , 296 , 297 , 298 , 299 ]
Trapianto renale e idrogeno molecolare	[ 30 , 51 ]
Trapianto intestinale e idrogeno molecolare	[ 89 , 300 , 301 ]
Trapianto di pancreas e idrogeno molecolare	[ 302 ]
Innesti osteocondrali e idrogeno molecolare	[ 303 ]
GVHD acuto e idrogeno molecolare	[ 304 , 305 ]
Rianimazione e idrogeno molecolare
Arresto cardiaco e idrogeno molecolare	[ 306 , 307 ]
Shock emorragico e idrogeno molecolare	[ 75 , 308 , 309 ]
Dialisi e idrogeno molecolare
Emodialisi e idrogeno molecolare	[ 310 , 311 , 312 , 313 ]
Dialisi peritoneale e idrogeno molecolare	[ 314 , 315 ]
Altre condizioni di salute e idrogeno molecolare
Estensione della durata della vita e idrogeno molecolare	[ 316 ]
Motilità spermatica e idrogeno molecolare	[ 317 ]
Malattia da decompressione e idrogeno molecolare	[ 318 ]
Genotossicità e mutagenicità e idrogeno molecolare	[ 319 ]
Piante e idrogeno molecolare
Organogenesi di radice e idrogeno molecolare	[ 91 , 320 ]
Tolleranza al sale e idrogeno molecolare	[ 321 , 322 ]
Maturazione post-raccolta e idrogeno molecolare	[ 323 ]
Chiusura stomatica e idrogeno molecolare	[ 324 ]
Tolleranza ai germogli di ravanello ai raggi UVA e idrogeno molecolare	[ 325 ]
Elevato stress luminoso e idrogeno molecolare	[ 326 ]
Segnalazione di fitoormoni e risposte allo stress e idrogeno molecolare	[ 327 ]
Tolleranza allo stress ossidativo indotto dal paraquat e all’idrogeno molecolare	[ 328 ]
Tossicità per cadmio e idrogeno molecolare	[ 329 , 330 ]
Tossicità per mercurio e idrogeno molecolare	[ 331 ]

Ancora una volta si può trarre beneficio dall’idrogeno molecolare H ₂ indipendentemente dal metodo di somministrazione, compreso il consumo di acqua molecolare di idrogeno che si è rivelata di gran lunga superiore rispetto all’inalazione di gas idrogeno, ad esempio – leggi di più sulle modalità di somministrazione dell’idrogeno molecolare (in acqua, gas o salino) per animali, esseri umani e piante Si prevede che l’acqua molecolare ricca di idrogeno possa essere facilmente utilizzata al posto dell’acqua normale quotidiana e curerà efficacemente malattie croniche come le malattie legate allo stile di vita. Inoltre, l’acqua di idrogeno molecolare è sicura e facile da bere a casa ( pensiamo che sia più facile bere acqua di idrogeno molecolare che iniettare soluzione salina ricca di idrogeno molecolare o inalare gas idrogeno molecolare)

idrogeno molecolare biatomico H _2- Prodotti per l’acqua idrogenata

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13(6):688–94. doi:https://doi.org/10.1038/nm1577.PubMedView ArticleGoogle Scholar
Dole M, Wilson FR, Fife WP. Hyperbaric hydrogen therapy: a possible treatment for cancer. Science. 1975;190(4210):152–4.PubMedView ArticleGoogle Scholar
Roberts BJ, Fife WP, Corbett TH, Schabel Jr FM. Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen. Cancer Treat Rep. 1978;62(7):1077–9.PubMedGoogle Scholar
Abraini JH, Gardette-Chauffour MC, Martinez E, Rostain JC, Lemaire C. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol. 1994;76(3):1113–8.PubMedGoogle Scholar
Gharib B, Hanna S, Abdallahi OM, Lepidi H, Gardette B, De Reggi M. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III. 2001;324(8):719–24.PubMedView ArticleGoogle Scholar
Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, et al. Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochem Biophys Res Commun. 1997;234(1):269–74. doi:https://doi.org/10.1006/bbrc.1997.6622.PubMedView ArticleGoogle Scholar
Li Y, Nishimura T, Teruya K, Maki T, Komatsu T, Hamasaki T, et al. Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology. 2002;40(1–3):139–49. doi:https://doi.org/10.1023/A%3A1023936421448.PubMed CentralPubMedView ArticleGoogle Scholar
Huang KC, Yang CC, Lee KT, Chien CT. Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int. 2003;64(2):704–14. doi:https://doi.org/10.1046/j.1523-1755.2003.00118.x.PubMedView ArticleGoogle Scholar
Yanagihara T, Arai K, Miyamae K, Sato B, Shudo T, Yamada M, et al. Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats. Biosci Biotechnol Biochem. 2005;69(10):1985–7.PubMedView ArticleGoogle Scholar
Huang G, Zhou J, Zhan W, Xiong Y, Hu C, Li X, et al. The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation. 2013;84(5):690–5. doi:https://doi.org/10.1016/j.resuscitation.2012.10.018.PubMedView ArticleGoogle Scholar
Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, et al. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res. 2012;2(1):15. doi:https://doi.org/10.1186/2045-9912-2-15.PubMed CentralPubMedView ArticleGoogle Scholar
Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, et al. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem. 2015;403(1–2):231–41. doi:https://doi.org/10.1007/s11010-015-2353-y.PubMedView ArticleGoogle Scholar
Qiu X, Li H, Tang H, Jin Y, Li W, Sun Y, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2011;11(12):2130–7. doi:https://doi.org/10.1016/j.intimp.2011.09.007.PubMedView ArticleGoogle Scholar
Xie K, Yu Y, Huang Y, Zheng L, Li J, Chen H, et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock. 2012;37(5):548–55. doi:https://doi.org/10.1097/SHK.0b013e31824ddc81.PubMedGoogle Scholar
Hattori Y, Kotani T, Tsuda H, Mano Y, Tu L, Li H, et al. Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. Free Radic Res. 2015;49:1026–37. doi:https://doi.org/10.3109/10715762.2015.1038257.PubMedView ArticleGoogle Scholar
Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res. 2015;198:41–9. doi:https://doi.org/10.1016/j.jss.2015.04.055.PubMedView ArticleGoogle Scholar
Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008;373(1):30–5. doi:https://doi.org/10.1016/j.bbrc.2008.05.165.PubMedView ArticleGoogle Scholar
Sakai K, Cho S, Shibata I, Yoshitomi O, Maekawa T, Sumikawa K. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scand Cardiovasc J. 2012;46(3):183–9. doi:https://doi.org/10.3109/14017431.2012.659676.PubMedView ArticleGoogle Scholar
Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, et al. H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs. Cardiovasc Drugs Ther. 2012;26(3):217–26. doi:https://doi.org/10.1007/s10557-012-6381-5.PubMedView ArticleGoogle Scholar
Shinbo T, Kokubo K, Sato Y, Hagiri S, Hataishi R, Hirose M, et al. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol. 2013;305(4):H542–50. doi:https://doi.org/10.1152/ajpheart.00844.2012.PubMedView ArticleGoogle Scholar
Sun Q, Kang Z, Cai J, Liu W, Liu Y, Zhang JH, et al. Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med (Maywood). 2009;234(10):1212–9. doi:https://doi.org/10.3181/0812-RM-349.View ArticleGoogle Scholar
Zhang Y, Sun Q, He B, Xiao J, Wang Z, Sun X. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 2011;148(1):91–5. doi:https://doi.org/10.1016/j.ijcard.2010.08.058.PubMedView ArticleGoogle Scholar
Jing L, Wang Y, Zhao XM, Zhao B, Han JJ, Qin SC, et al. Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart Lung Circ. 2015;24(6):602–10. doi:https://doi.org/10.1016/j.hlc.2014.11.018.PubMedView ArticleGoogle Scholar
Zhang G, Gao S, Li X, Zhang L, Tan H, Xu L, et al. Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci Rep. 2015;5:9858. doi:https://doi.org/10.1038/srep09858.PubMed CentralPubMedView ArticleGoogle Scholar
Ohno K, Ito M, Ichihara M, Ito M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev. 2012;2012:353152. doi:https://doi.org/10.1155/2012/353152.PubMed CentralPubMedView ArticleGoogle Scholar
Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651–6. doi:https://doi.org/10.1016/j.bbrc.2009.09.047.PubMedView ArticleGoogle Scholar
Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, et al. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun. 2011;411(1):143–9. doi:https://doi.org/10.1016/j.bbrc.2011.06.116.PubMedView ArticleGoogle Scholar
Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J. Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Crit Care Med. 2013;41(5):1266–75. doi:https://doi.org/10.1097/CCM.0b013e31827711c9.PubMed CentralPubMedView ArticleGoogle Scholar
Chen Y, Jiang J, Miao H, Chen X, Sun X, Li Y. Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. Int J Mol Med. 2013;31(3):597–606. doi:https://doi.org/10.3892/ijmm.2013.1256.PubMedGoogle Scholar
Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, et al. Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010;77(2):101–9. doi:https://doi.org/10.1038/ki.2009.421.PubMedView ArticleGoogle Scholar
Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, et al. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver Int. 2010;30(7):958–68. doi:https://doi.org/10.1111/j.1478-3231.2010.02254.x.PubMedView ArticleGoogle Scholar
Kasuyama K, Tomofuji T, Ekuni D, Tamaki N, Azuma T, Irie K, et al. Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol. 2011;38(12):1085–90. doi:https://doi.org/10.1111/j.1600-051X.2011.01801.x.PubMedView ArticleGoogle Scholar
Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, et al. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun. 2012;425(4):873–9. doi:https://doi.org/10.1016/j.bbrc.2012.08.005.PubMed CentralPubMedView ArticleGoogle Scholar
Sun Y, Shuang F, Chen DM, Zhou RB. Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int. 2013;24(3):969–78. doi:https://doi.org/10.1007/s00198-012-2028-4.PubMedView ArticleGoogle Scholar
Xu XF, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res. 2013;62(4):395–403.PubMedGoogle Scholar
Li DZ, Zhang QX, Dong XX, Li HD, Ma X. Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab. 2014;32(5):494–504. doi:https://doi.org/10.1007/s00774-013-0530-1.PubMedView ArticleGoogle Scholar
Guo SX, Fang Q, You CG, Jin YY, Wang XG, Hu XL, et al. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Transl Med. 2015;13:183. doi:https://doi.org/10.1186/s12967-015-0548-3.PubMed CentralPubMedView ArticleGoogle Scholar
Liu X, Chen Z, Mao N, Xie Y. The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol. 2012;13(2):197–203. doi:https://doi.org/10.1016/j.intimp.2012.04.004.PubMedView ArticleGoogle Scholar
Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013;40(6):857–63.PubMedView ArticleGoogle Scholar
Wu F, Qiu Y, Ye G, Luo H, Jiang J, Yu F, et al. Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice. Cardiovasc Pathol. 2015;24:294–303. doi:https://doi.org/10.1016/j.carpath.2015.04.008.PubMedView ArticleGoogle Scholar
Zhai Y, Zhou X, Dai Q, Fan Y, Huang X. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol. 2015;98(2):268–76. doi:https://doi.org/10.1016/j.yexmp.2015.03.005.PubMedView ArticleGoogle Scholar
Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, et al. The protective role of hydrogen-rich saline in experimental liver injury in mice. J Hepatol. 2011;54(3):471–80. doi:https://doi.org/10.1016/j.jhep.2010.08.011.PubMedView ArticleGoogle Scholar
Wang C, Li J, Liu Q, Yang R, Zhang JH, Cao YP, et al. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neurosci Lett. 2011;491(2):127–32. doi:https://doi.org/10.1016/j.neulet.2011.01.022.PubMedView ArticleGoogle Scholar
Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, et al. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Med Gas Res. 2013;3(1):6. doi:https://doi.org/10.1186/2045-9912-3-6.PubMed CentralPubMedView ArticleGoogle Scholar
Shin MH, Park R, Nojima H, Kim HC, Kim YK, Chung JH. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLoS One. 2013;8(4):e61696. doi:https://doi.org/10.1371/journal.pone.0061696.PubMed CentralPubMedView ArticleGoogle Scholar
Liu YQ, Liu YF, Ma XM, Xiao YD, Wang YB, Zhang MZ, et al. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. J Plast Reconstr Aesthet Surg. 2015;68(7):e147–56. doi:https://doi.org/10.1016/j.bjps.2015.03.001.PubMedView ArticleGoogle Scholar
Zhang JY, Song SD, Pang Q, Zhang RY, Wan Y, Yuan DW, et al. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol. 2015;21(14):4195–209. doi:https://doi.org/10.3748/wjg.v21.i14.4195.PubMed CentralPubMedView ArticleGoogle Scholar
Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, et al. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One. 2014;9(4):e96212. doi:https://doi.org/10.1371/journal.pone.0096212.PubMed CentralPubMedView ArticleGoogle Scholar
Guo SX, Jin YY, Fang Q, You CG, Wang XG, Hu XL, et al. Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One. 2015;10(4):e0124897. doi:https://doi.org/10.1371/journal.pone.0124897.PubMed CentralPubMedView ArticleGoogle Scholar
Wei L, Ge L, Qin S, Shi Y, Du C, Du H, et al. Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Exp Eye Res. 2012;94(1):117–27. doi:https://doi.org/10.1016/j.exer.2011.11.016.PubMedView ArticleGoogle Scholar
Abe T, Li XK, Yazawa K, Hatayama N, Xie L, Sato B, et al. Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation. 2012;94(1):14–21. doi:https://doi.org/10.1097/TP.0b013e318255f8be.PubMedView ArticleGoogle Scholar
Noda K, Shigemura N, Tanaka Y, Kawamura T, Hyun Lim S, Kokubo K, et al. A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Heart Lung Transplant. 2013;32(2):241–50. doi:https://doi.org/10.1016/j.healun.2012.11.004.PubMedView ArticleGoogle Scholar
Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun. 2011;408(2):253–8. doi:https://doi.org/10.1016/j.bbrc.2011.04.008.PubMedView ArticleGoogle Scholar
Song G, Tian H, Liu J, Zhang H, Sun X, Qin S. H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnol Lett. 2011;33(9):1715–22. doi:https://doi.org/10.1007/s10529-011-0630-8.PubMedView ArticleGoogle Scholar
Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, et al. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011;52(1):427–33. doi:https://doi.org/10.1167/iovs.10-6167.PubMedView ArticleGoogle Scholar
Ji Q, Hui K, Zhang L, Sun X, Li W, Duan M. The effect of hydrogen-rich saline on the brain of rats with transient ischemia. J Surg Res. 2011;168(1):e95–101. doi:https://doi.org/10.1016/j.jss.2011.01.057.PubMedView ArticleGoogle Scholar
Shen L, Wang J, Liu K, Wang C, Wang C, Wu H, et al. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochem Res. 2011;36(8):1501–11. doi:https://doi.org/10.1007/s11064-011-0476-4.PubMedView ArticleGoogle Scholar
Qin ZX, Yu P, Qian DH, Song MB, Tan H, Yu Y, et al. Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway. Atherosclerosis. 2012;220(2):343–50. doi:https://doi.org/10.1016/j.atherosclerosis.2011.11.002.PubMedView ArticleGoogle Scholar
Song G, Tian H, Qin S, Sun X, Yao S, Zong C, et al. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis. 2012;221(1):55–65. doi:https://doi.org/10.1016/j.atherosclerosis.2011.11.043.PubMedView ArticleGoogle Scholar
Zheng H, Yu YS. Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochem Pharmacol. 2012;83(9):1269–77. doi:https://doi.org/10.1016/j.bcp.2012.01.031.PubMedView ArticleGoogle Scholar
Hong Y, Guo S, Chen S, Sun C, Zhang J, Sun X. Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res. 2012;90(8):1670–80. doi:https://doi.org/10.1002/jnr.22739.PubMedView ArticleGoogle Scholar
Guo JD, Li L, Shi YM, Wang HD, Hou SX. Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol. 2013;168(6):1412–20. doi:https://doi.org/10.1111/bph.12036.PubMed CentralPubMedView ArticleGoogle Scholar
Xiao M, Zhu T, Wang T, Wen FQ. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci. 2013;17(8):1033–43.PubMedGoogle Scholar
Liu GD, Zhang H, Wang L, Han Q, Zhou SF, Liu P. Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol. 2013;6(3):280–5. doi:https://doi.org/10.3980/j.issn.2222-3959.2013.03.05.PubMed CentralPubMedGoogle Scholar
Li FY, Zhu SX, Wang ZP, Wang H, Zhao Y, Chen GP. Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. Food Chem Toxicol. 2013;61:248–54. doi:https://doi.org/10.1016/j.fct.2013.10.004.PubMedView ArticleGoogle Scholar
Zhuang Z, Sun XJ, Zhang X, Liu HD, You WC, Ma CY, et al. Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res. 2013;91(12):1599–608. doi:https://doi.org/10.1002/jnr.23281.PubMedView ArticleGoogle Scholar
Tan YC, Xie F, Zhang HL, Zhu YL, Chen K, Tan HM, et al. Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol. 2014;38(3):337–45. doi:https://doi.org/10.1016/j.clinre.2013.11.007.PubMedView ArticleGoogle Scholar
Zhang J, Wu Q, Song S, Wan Y, Zhang R, Tai M, et al. Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol. 2014;21(1):94–101. doi:https://doi.org/10.1016/j.intimp.2014.04.011.PubMedView ArticleGoogle Scholar
Xin HG, Zhang BB, Wu ZQ, Hang XF, Xu WS, Ni W, et al. Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem. 2014;392(1–2):117–24. doi:https://doi.org/10.1007/s11010-014-2024-4.PubMedView ArticleGoogle Scholar
Wang X, Yu P, Yong Y, Liu X, Jiang J, Liu D, et al. Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns. 2015;41(2):379–85. doi:https://doi.org/10.1016/j.burns.2014.07.012.PubMedView ArticleGoogle Scholar
Zhang CB, Tang YC, Xu XJ, Guo SX, Wang HZ. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappaB signaling pathway. Exp Ther Med. 2015;9(6):2114–20. doi:https://doi.org/10.3892/etm.2015.2385.PubMed CentralPubMedGoogle Scholar
Shi Q, Liao KS, Zhao KL, Wang WX, Zuo T, Deng WH, et al. Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-kappaB pathway. Mediators Inflamm. 2015;2015:685043. doi:https://doi.org/10.1155/2015/685043.PubMed CentralPubMedGoogle Scholar
Shao A, Wu H, Hong Y, Tu S, Sun X, Wu Q et al. Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol. 2015. doi:https://doi.org/10.1007/s12035-015-9242-y.
Chen X, Liu Q, Wang D, Feng S, Zhao Y, Shi Y, et al. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev. 2015;2015:106836. doi:https://doi.org/10.1155/2015/106836.PubMed CentralPubMedGoogle Scholar
Kohama K, Yamashita H, Aoyama-Ishikawa M, Takahashi T, Billiar TR, Nishimura T, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery. 2015;158(2):399–407. doi:https://doi.org/10.1016/j.surg.2015.03.038.PubMedView ArticleGoogle Scholar
Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, et al. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm. 2014;2014:930894. doi:https://doi.org/10.1155/2014/930894.PubMed CentralPubMedGoogle Scholar
Liu FT, Xu SM, Xiang ZH, Li XN, Li J, Yuan HB, et al. Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats. CNS Neurosci Ther. 2014;20(8):778–86. doi:https://doi.org/10.1111/cns.12258.PubMedView ArticleGoogle Scholar
Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y, Ohno K, et al. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. J Thorac Cardiovasc Surg. 2015;150:645–54. doi:https://doi.org/10.1016/j.jtcvs.2015.05.052.PubMedView ArticleGoogle Scholar
Zhang L, Shu R, Wang C, Wang H, Li N, Wang G. Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull. 2014;106:47–55. doi:https://doi.org/10.1016/j.brainresbull.2014.05.005.PubMedView ArticleGoogle Scholar
Xie K, Wang W, Chen H, Han H, Liu D, Wang G, et al. Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase. Shock. 2015;44(1):58–64. doi:https://doi.org/10.1097/SHK.0000000000000365.PubMedView ArticleGoogle Scholar
Spulber S, Edoff K, Hong L, Morisawa S, Shirahata S, Ceccatelli S. Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One. 2012;7(7):e42078. doi:https://doi.org/10.1371/journal.pone.0042078.PubMed CentralPubMedView ArticleGoogle Scholar
Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol. 2013;304(10):L646–56. doi:https://doi.org/10.1152/ajplung.00164.2012.PubMed CentralPubMedView ArticleGoogle Scholar
Zhai X, Chen X, Shi J, Shi D, Ye Z, Liu W, et al. Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. Free Radic Biol Med. 2013;65:731–41. doi:https://doi.org/10.1016/j.freeradbiomed.2013.08.004.PubMedView ArticleGoogle Scholar
Xie Q, Li XX, Zhang P, Li JC, Cheng Y, Feng YL, et al. Hydrogen gas protects against serum and glucose deprivationinduced myocardial injury in H9c2 cells through activation of the NFE2related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep. 2014;10(2):1143–9. doi:https://doi.org/10.3892/mmr.2014.2283.PubMedGoogle Scholar
Song G, Zong C, Zhang Z, Yu Y, Yao S, Jiao P, et al. Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice. Free Radic Biol Med. 2015;87:58–68. doi:https://doi.org/10.1016/j.freeradbiomed.2015.06.018.PubMedView ArticleGoogle Scholar
Li Y, Xie K, Chen H, Wang G, Yu Y. Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. J Surg Res. 2015;196(1):136–48. doi:https://doi.org/10.1016/j.jss.2015.02.042.PubMedView ArticleGoogle Scholar
Li Y, Li Q, Chen H, Wang T, Liu L, Wang G, et al. Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1. Shock. 2015;44(1):90–8. doi:https://doi.org/10.1097/SHK.0000000000000382.PubMedView ArticleGoogle Scholar
Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N, Billiar TR, et al. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery. 2011;150(2):240–9. doi:https://doi.org/10.1016/j.surg.2011.05.019.PubMedView ArticleGoogle Scholar
Buchholz BM, Masutani K, Kawamura T, Peng X, Toyoda Y, Billiar TR, et al. Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation. 2011;92(9):985–92. doi:https://doi.org/10.1097/TP.0b013e318230159d.PubMedGoogle Scholar
Chen HG, Xie KL, Han HZ, Wang WN, Liu DQ, Wang GL, et al. Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg. 2013;11(10):1060–6. doi:https://doi.org/10.1016/j.ijsu.2013.10.007.PubMedView ArticleGoogle Scholar
Lin Y, Zhang W, Qi F, Cui W, Xie Y, Shen W. Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner. J Plant Physiol. 2014;171(2):1–8. doi:https://doi.org/10.1016/j.jplph.2013.08.009.PubMedView ArticleGoogle Scholar
Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, et al. H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015;38:1835–46. doi:https://doi.org/10.1007/s10753-015-0161-x.PubMedView ArticleGoogle Scholar
Yu J, Zhang W, Zhang R, Ruan X, Ren P, Lu B. Lactulose accelerates liver regeneration in rats by inducing hydrogen. J Surg Res. 2015;195(1):128–35. doi:https://doi.org/10.1016/j.jss.2015.01.034.PubMedView ArticleGoogle Scholar
Wei R, Zhang R, Xie Y, Shen L, Chen F. Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress. Cell Physiol Biochem. 2015;36(2):585–98. doi:https://doi.org/10.1159/000430122.PubMedView ArticleGoogle Scholar
Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep. 2013;3:3273. doi:https://doi.org/10.1038/srep03273.PubMed CentralPubMedView ArticleGoogle Scholar
Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N. Pilot study of H(2) therapy in Parkinson’s disease: a randomized double-blind placebo-controlled trial. Mov Disord. 2013;28(6):836–9. doi:https://doi.org/10.1002/mds.25375.PubMedView ArticleGoogle Scholar
Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, et al. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One. 2009;4(9):e7247. doi:https://doi.org/10.1371/journal.pone.0007247.PubMed CentralPubMedView ArticleGoogle Scholar
Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 2007;361(3):670–4. doi:https://doi.org/10.1016/j.bbrc.2007.07.088.PubMedView ArticleGoogle Scholar
Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, et al. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 2010;169(1):402–14. doi:https://doi.org/10.1016/j.neuroscience.2010.04.043.PubMed CentralPubMedView ArticleGoogle Scholar
Hugyecz M, Mracsko E, Hertelendy P, Farkas E, Domoki F, Bari F. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Res. 2011;1404:31–8. doi:https://doi.org/10.1016/j.brainres.2011.05.068.PubMedView ArticleGoogle Scholar
Ono H, Nishijima Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, et al. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Med Gas Res. 2011;1(1):12. doi:https://doi.org/10.1186/2045-9912-1-12.PubMed CentralPubMedView ArticleGoogle Scholar
Liu Y, Liu W, Sun X, Li R, Sun Q, Cai J, et al. Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Med Gas Res. 2011;1(1):15. doi:https://doi.org/10.1186/2045-9912-1-15.PubMed CentralPubMedView ArticleGoogle Scholar
Li J, Dong Y, Chen H, Han H, Yu Y, Wang G, et al. Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Res. 2012;1486:103–11. doi:https://doi.org/10.1016/j.brainres.2012.09.031.PubMedView ArticleGoogle Scholar
Nagatani K, Wada K, Takeuchi S, Kobayashi H, Uozumi Y, Otani N, et al. Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. Shock. 2012;37(6):645–52. doi:https://doi.org/10.1097/SHK.0b013e31824ed57c.PubMedView ArticleGoogle Scholar
Ge P, Zhao J, Li S, Ding Y, Yang F, Luo Y. Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurol Res. 2012;34(2):187–94. doi:https://doi.org/10.1179/1743132812Y.0000000002.PubMedGoogle Scholar
Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, et al. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res. 2013;3(1):13. doi:https://doi.org/10.1186/2045-9912-3-13.PubMed CentralPubMedView ArticleGoogle Scholar
Olah O, Toth-Szuki V, Temesvari P, Bari F, Domoki F. Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology. 2013;104(2):79–86. doi:https://doi.org/10.1159/000348445.PubMedView ArticleGoogle Scholar
Cui Y, Zhang H, Ji M, Jia M, Chen H, Yang J, et al. Hydrogen-rich saline attenuates neuronal ischemia–reperfusion injury by protecting mitochondrial function in rats. J Surg Res. 2014;192(2):564–72. doi:https://doi.org/10.1016/j.jss.2014.05.060.PubMedView ArticleGoogle Scholar
Han L, Tian R, Yan H, Pei L, Hou Z, Hao S, et al. Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res. 2015;1615:129–38. doi:https://doi.org/10.1016/j.brainres.2015.04.038.PubMedView ArticleGoogle Scholar
Takeuchi S, Nagatani K, Otani N, Nawashiro H, Sugawara T, Wada K, et al. Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci. 2015;16(1):22. doi:https://doi.org/10.1186/s12868-015-0165-3.PubMed CentralPubMedView ArticleGoogle Scholar
Zhuang Z, Zhou ML, You WC, Zhu L, Ma CY, Sun XJ, et al. Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci. 2012;13:47. doi:https://doi.org/10.1186/1471-2202-13-47.PubMed CentralPubMedView ArticleGoogle Scholar
Zhan Y, Chen C, Suzuki H, Hu Q, Zhi X, Zhang JH. Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med. 2012;40(4):1291–6. doi:https://doi.org/10.1097/CCM.0b013e31823da96d.PubMed CentralPubMedView ArticleGoogle Scholar
Takeuchi S, Mori K, Arimoto H, Fujii K, Nagatani K, Tomura S, et al. Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. BMC Neurol. 2014;14:176. doi:https://doi.org/10.1186/s12883-014-0176-1.PubMed CentralPubMedView ArticleGoogle Scholar
Ji X, Liu W, Xie K, Liu W, Qu Y, Chao X, et al. Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Res. 2010;1354:196–205. doi:https://doi.org/10.1016/j.brainres.2010.07.038.PubMedView ArticleGoogle Scholar
Eckermann JM, Chen W, Jadhav V, Hsu FP, Colohan AR, Tang J, et al. Hydrogen is neuroprotective against surgically induced brain injury. Med Gas Res. 2011;1(1):7. doi:https://doi.org/10.1186/2045-9912-1-7.PubMed CentralPubMedView ArticleGoogle Scholar
Hou Z, Luo W, Sun X, Hao S, Zhang Y, Xu F, et al. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull. 2012;88(6):560–5. doi:https://doi.org/10.1016/j.brainresbull.2012.06.006.PubMedView ArticleGoogle Scholar
Ji X, Tian Y, Xie K, Liu W, Qu Y, Fei Z. Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. J Surg Res. 2012;178(1):e9–16. doi:https://doi.org/10.1016/j.jss.2011.12.038.PubMedView ArticleGoogle Scholar
Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, et al. Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury. PLoS One. 2014;9(9):e108034. doi:https://doi.org/10.1371/journal.pone.0108034.PubMed CentralPubMedView ArticleGoogle Scholar
Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci Lett. 2009;453(2):81–5. doi:https://doi.org/10.1016/j.neulet.2009.02.016.PubMedView ArticleGoogle Scholar
Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res. 2010;1328:152–61. doi:https://doi.org/10.1016/j.brainres.2010.02.046.PubMedView ArticleGoogle Scholar
Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology. 2009;34(2):501–8. doi:https://doi.org/10.1038/npp.2008.95.PubMedView ArticleGoogle Scholar
Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, et al. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr. 2010;46(3):269–76. doi:https://doi.org/10.3164/jcbn.10-19.PubMed CentralPubMedView ArticleGoogle Scholar
Liu L, Xie K, Chen H, Dong X, Li Y, Yu Y, et al. Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res. 2014;1589:78–92. doi:https://doi.org/10.1016/j.brainres.2014.09.030.PubMedView ArticleGoogle Scholar
Ueda Y, Nakajima A, Oikawa T. Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride. Neurochem Res. 2010;35(10):1510–5. doi:https://doi.org/10.1007/s11064-010-0204-5.PubMedView ArticleGoogle Scholar
Kashiwagi T, Yan H, Hamasaki T, Kinjo T, Nakamichi N, Teruya K, et al. Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev. 2014;2014:869121. doi:https://doi.org/10.1155/2014/869121.PubMed CentralPubMedView ArticleGoogle Scholar
Huang Y, Xie K, Li J, Xu N, Gong G, Wang G, et al. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Res. 2011;1378:125–36. doi:https://doi.org/10.1016/j.brainres.2010.12.071.PubMedView ArticleGoogle Scholar
Zhou L, Wang X, Xue W, Xie K, Huang Y, Chen H, et al. Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Res. 2013;1517:150–60. doi:https://doi.org/10.1016/j.brainres.2013.04.007.PubMedView ArticleGoogle Scholar
Chen C, Chen Q, Mao Y, Xu S, Xia C, Shi X, et al. Hydrogen-rich saline protects against spinal cord injury in rats. Neurochem Res. 2010;35(7):1111–8. doi:https://doi.org/10.1007/s11064-010-0162-y.PubMedView ArticleGoogle Scholar
Ge Y, Wu F, Sun X, Xiang Z, Yang L, Huang S, et al. Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLoS One. 2014;9(5):e97436. doi:https://doi.org/10.1371/journal.pone.0097436.PubMed CentralPubMedView ArticleGoogle Scholar
Kawaguchi M, Satoh Y, Otsubo Y, Kazama T. Molecular hydrogen attenuates neuropathic pain in mice. PLoS One. 2014;9(6):e100352. doi:https://doi.org/10.1371/journal.pone.0100352.PubMed CentralPubMedView ArticleGoogle Scholar
Zhang L, Shu R, Wang H, Yu Y, Wang C, Yang M, et al. Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats. Neuroscience. 2014;280:171–80. doi:https://doi.org/10.1016/j.neuroscience.2014.09.024.PubMedView ArticleGoogle Scholar
Shu RC, Zhang LL, Wang CY, Li N, Wang HY, Xie KL, et al. Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats. Anesthesiology. 2015;122(4):908–20. doi:https://doi.org/10.1097/ALN.0000000000000562.PubMedView ArticleGoogle Scholar
Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, et al. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2010;51(1):487–92. doi:https://doi.org/10.1167/iovs.09-4089.PubMedView ArticleGoogle Scholar
Liu H, Hua N, Xie K, Zhao T, Yu Y. Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury. Mol Med Rep. 2015;12(2):2495–502. doi:https://doi.org/10.3892/mmr.2015.3731.PubMed CentralPubMedGoogle Scholar
Xiao X, Cai J, Xu J, Wang R, Cai J, Liu Y, et al. Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. J Ocul Pharmacol Ther. 2012;28(1):76–82. doi:https://doi.org/10.1089/jop.2010.0129.PubMedView ArticleGoogle Scholar
Feng Y, Wang R, Xu J, Sun J, Xu T, Gu Q, et al. Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res. 2013;38(3):396–404. doi:https://doi.org/10.3109/02713683.2012.748919.PubMedView ArticleGoogle Scholar
Huang L, Zhao S, Zhang JH, Sun X. Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res. 2012;47(3):122–7. doi:https://doi.org/10.1159/000329600.PubMedView ArticleGoogle Scholar
Feng M, Wang XH, Yang XB, Xiao Q, Jiang FG. Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol. 2012;5(2):151–7. doi:https://doi.org/10.3980/j.issn.2222-3959.2012.02.07.PubMed CentralPubMedGoogle Scholar
Tian L, Zhang L, Xia F, An J, Sugita Y, Zhang Z. Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. Med Gas Res. 2013;3(1):19. doi:https://doi.org/10.1186/2045-9912-3-19.PubMed CentralPubMedView ArticleGoogle Scholar
Yokota T, Kamimura N, Igarashi T, Takahashi H, Ohta S, Oharazawa H. Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experiment Ophthalmol. 2015;43:568–77. doi:https://doi.org/10.1111/ceo.12525.PubMedView ArticleGoogle Scholar
Sun JC, Xu T, Zuo Q, Wang RB, Qi AQ, Cao WL, et al. Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One. 2014;9(6):e99299. doi:https://doi.org/10.1371/journal.pone.0099299.PubMed CentralPubMedView ArticleGoogle Scholar
Yang CX, Yan H, Ding TB. Hydrogen saline prevents selenite-induced cataract in rats. Mol Vis. 2013;19:1684–93.PubMed CentralPubMedGoogle Scholar
Kikkawa YS, Nakagawa T, Horie RT, Ito J. Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009;20(7):689–94. doi:https://doi.org/10.1097/WNR.0b013e32832a5c68.PubMedView ArticleGoogle Scholar
Taura A, Kikkawa YS, Nakagawa T, Ito J. Hydrogen protects vestibular hair cells from free radicals. Acta Otolaryngol Suppl. 2010;130(563):95–100. doi:https://doi.org/10.3109/00016489.2010.486799.View ArticleGoogle Scholar
Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2011;487(1):12–6. doi:https://doi.org/10.1016/j.neulet.2010.09.064.PubMedView ArticleGoogle Scholar
Zhou Y, Zheng H, Ruan F, Chen X, Zheng G, Kang M, et al. Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neuroscience. 2012;209:47–53. doi:https://doi.org/10.1016/j.neuroscience.2012.02.028.PubMedView ArticleGoogle Scholar
Chen L, Yu N, Lu Y, Wu L, Chen D, Guo W, et al. Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect. PLoS One. 2014;9(6):e100774. doi:https://doi.org/10.1371/journal.pone.0100774.PubMed CentralPubMedView ArticleGoogle Scholar
Kurioka T, Matsunobu T, Satoh Y, Niwa K, Shiotani A. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res. 2014;89:69–74. doi:https://doi.org/10.1016/j.neures.2014.08.009.PubMedView ArticleGoogle Scholar
Qu J, Li X, Wang J, Mi W, Xie K, Qiu J. Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol. 2012;76(1):111–5. doi:https://doi.org/10.1016/j.ijporl.2011.10.014.PubMedView ArticleGoogle Scholar
Kikkawa YS, Nakagawa T, Taniguchi M, Ito J. Hydrogen protects auditory hair cells from cisplatin-induced free radicals. Neurosci Lett. 2014;579:125–9. doi:https://doi.org/10.1016/j.neulet.2014.07.025.PubMedView ArticleGoogle Scholar
Qu J, Gan YN, Xie KL, Liu WB, Wang YF, Hei RY, et al. Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacol Sin. 2012;33(4):445–51. doi:https://doi.org/10.1038/aps.2011.190.PubMed CentralPubMedView ArticleGoogle Scholar
Tomofuji T, Kawabata Y, Kasuyama K, Endo Y, Yoneda T, Yamane M, et al. Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep. 2014;4:5534. doi:https://doi.org/10.1038/srep05534.PubMed CentralPubMedView ArticleGoogle Scholar
Shi J, Yao F, Zhong C, Pan X, Yang Y, Lin Q. Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ. 2012;21(9):556–63. doi:https://doi.org/10.1016/j.hlc.2012.05.782.PubMedView ArticleGoogle Scholar
Li H, Zhou R, Liu J, Li Q, Zhang J, Mu J, et al. Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res. 2012;174(1):e11–6. doi:https://doi.org/10.1016/j.jss.2011.10.001.PubMedView ArticleGoogle Scholar
Zheng J, Liu K, Kang Z, Cai J, Liu W, Xu W, et al. Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med. 2010;37(3):185–92.PubMedGoogle Scholar
Sun Q, Cai J, Liu S, Liu Y, Xu W, Tao H, et al. Hydrogen-rich saline provides protection against hyperoxic lung injury. J Surg Res. 2011;165(1):e43–9. doi:https://doi.org/10.1016/j.jss.2010.09.024.PubMedView ArticleGoogle Scholar
Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, et al. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care. 2010;14(6):R234. doi:https://doi.org/10.1186/cc9389.PubMed CentralPubMedView ArticleGoogle Scholar
Liu H, Liang X, Wang D, Zhang H, Liu L, Chen H, et al. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock. 2015;43(5):504–11. doi:https://doi.org/10.1097/SHK.0000000000000316.PubMedView ArticleGoogle Scholar
Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2009;381(4):602–5. doi:https://doi.org/10.1016/j.bbrc.2009.02.105.PubMedView ArticleGoogle Scholar
Fang Y, Fu XJ, Gu C, Xu P, Wang Y, Yu WR, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res. 2011;32(3):e82–91. doi:https://doi.org/10.1097/BCR.0b013e318217f84f.PubMedView ArticleGoogle Scholar
Liu S, Liu K, Sun Q, Liu W, Xu W, Denoble P, et al. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol. 2011;2011:305086. doi:https://doi.org/10.1155/2011/305086.PubMed CentralPubMedGoogle Scholar
Sato C, Kamijo Y, Yoshimura K, Nagaki T, Yamaya T, Asakuma S, et al. Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. Kitasato Med J. 2015;45(1):9–16.Google Scholar
Ning Y, Shang Y, Huang H, Zhang J, Dong Y, Xu W, et al. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One. 2013;8(12):e83429. doi:https://doi.org/10.1371/journal.pone.0083429.PubMed CentralPubMedView ArticleGoogle Scholar
He B, Zhang Y, Kang B, Xiao J, Xie B, Wang Z. Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep. 2013;40(9):5513–21. doi:https://doi.org/10.1007/s11033-013-2653-9.PubMed CentralPubMedView ArticleGoogle Scholar
Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, et al. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. Am J Physiol Heart Circ Physiol. 2011;301(3):H1062–9. doi:https://doi.org/10.1152/ajpheart.00150.2011.PubMedView ArticleGoogle Scholar
Kato R, Nomura A, Sakamoto A, Yasuda Y, Amatani K, Nagai S, et al. Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol. 2014;307(11):H1626–33. doi:https://doi.org/10.1152/ajpheart.00228.2014.PubMedView ArticleGoogle Scholar
Yu YS, Zheng H. Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem. 2012;365(1–2):233–42. doi:https://doi.org/10.1007/s11010-012-1264-4.PubMedView ArticleGoogle Scholar
Zhang JY, Wu QF, Wan Y, Song SD, Xu J, Xu XS, et al. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol. 2014;20(6):1614–22. doi:https://doi.org/10.3748/wjg.v20.i6.1614.PubMed CentralPubMedView ArticleGoogle Scholar
Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, et al. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complement Altern Med. 2014;14:81. doi:https://doi.org/10.1186/1472-6882-14-81.PubMed CentralPubMedView ArticleGoogle Scholar
Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P, et al. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res. 2009;43(5):478–84. doi:https://doi.org/10.1080/10715760902870603.PubMedView ArticleGoogle Scholar
Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, et al. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res. 2011;167(2):316–22. doi:https://doi.org/10.1016/j.jss.2009.07.045.PubMedView ArticleGoogle Scholar
Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009;386(1):11–5. doi:https://doi.org/10.1016/j.bbrc.2009.05.117.PubMedView ArticleGoogle Scholar
He J, Xiong S, Zhang J, Wang J, Sun A, Mei X, et al. Protective effects of hydrogen-rich saline on ulcerative colitis rat model. J Surg Res. 2013;185(1):174–81. doi:https://doi.org/10.1016/j.jss.2013.05.047.PubMedView ArticleGoogle Scholar
Chen X, Zhai X, Shi J, Liu WW, Tao H, Sun X, et al. Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production. Dig Dis Sci. 2013;58(6):1560–8. doi:https://doi.org/10.1007/s10620-013-2563-7.PubMedView ArticleGoogle Scholar
Sheng Q, Lv Z, Cai W, Song H, Qian L, Wang X. Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg. 2013;48(8):1697–706. doi:https://doi.org/10.1016/j.jpedsurg.2012.11.038.PubMedView ArticleGoogle Scholar
Nishimura N, Tanabe H, Sasaki Y, Makita Y, Ohata M, Yokoyama S, et al. Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr. 2012;107(4):485–92. doi:https://doi.org/10.1017/S0007114511003229.PubMedView ArticleGoogle Scholar
Liu Y, Yang L, Tao K, Vizcaychipi MP, Lloyd DM, Sun X, et al. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol. 2014;14:12. doi:https://doi.org/10.1186/1471-230X-14-12.PubMed CentralPubMedView ArticleGoogle Scholar
Matsuno N, Watanabe R, Kimura M, Iwata S, Fujiyama M, Kono S, et al. Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc. 2014;46(4):1104–6. doi:https://doi.org/10.1016/j.transproceed.2013.11.134.PubMedView ArticleGoogle Scholar
Xia C, Liu W, Zeng D, Zhu L, Sun X, Sun X. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci. 2013;6(5):372–5. doi:https://doi.org/10.1111/cts.12076.PubMedView ArticleGoogle Scholar
Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, et al. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology. 2012;56(3):912–21. doi:https://doi.org/10.1002/hep.25782.PubMedView ArticleGoogle Scholar
Xiang L, Tan JW, Huang LJ, Jia L, Liu YQ, Zhao YQ, et al. Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World J Gastroenterol. 2012;18(37):5197–204. doi:https://doi.org/10.3748/wjg.v18.i37.5197.PubMed CentralPubMedGoogle Scholar
Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, et al. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009;386(2):316–21. doi:https://doi.org/10.1016/j.bbrc.2009.06.024.PubMedView ArticleGoogle Scholar
Lee PC, Yang YY, Huang CS, Hsieh SL, Lee KC, Hsieh YC, et al. Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res. 2015;45(5):578–88. doi:https://doi.org/10.1111/hepr.12379.PubMedView ArticleGoogle Scholar
Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, et al. Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res. 2014;44(6):663–77. doi:https://doi.org/10.1111/hepr.12165.PubMedView ArticleGoogle Scholar
Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, et al. Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun. 2010;393(2):308–13. doi:https://doi.org/10.1016/j.bbrc.2010.02.005.PubMedView ArticleGoogle Scholar
Ren J, Luo Z, Tian F, Wang Q, Li K, Wang C. Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg. 2012;72(6):1555–61. doi:https://doi.org/10.1097/TA.0b013e31824a7913.PubMedView ArticleGoogle Scholar
Zhang DQ, Feng H, Chen WC. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med. 2013;2013:731932. doi:https://doi.org/10.1155/2013/731932.PubMed CentralPubMedGoogle Scholar
Zhu WJ, Nakayama M, Mori T, Nakayama K, Katoh J, Murata Y, et al. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrol Dial Transplant. 2011;26(7):2112–8. doi:https://doi.org/10.1093/ndt/gfq727.PubMedView ArticleGoogle Scholar
Shingu C, Koga H, Hagiwara S, Matsumoto S, Goto K, Yokoi I, et al. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. J Anesth. 2010;24(4):569–74. doi:https://doi.org/10.1007/s00540-010-0942-1.PubMedView ArticleGoogle Scholar
Wang F, Yu G, Liu SY, Li JB, Wang JF, Bo LL, et al. Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. J Surg Res. 2011;167(2):e339–44. doi:https://doi.org/10.1016/j.jss.2010.11.005.PubMedView ArticleGoogle Scholar
Xu B, Zhang YB, Li ZZ, Yang MW, Wang S, Jiang DP. Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats. Int Immunopharmacol. 2013;17(2):447–52. doi:https://doi.org/10.1016/j.intimp.2013.06.033.PubMedView ArticleGoogle Scholar
Gu H, Yang M, Zhao X, Zhao B, Sun X, Gao X. Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res. 2014;188(1):243–9. doi:https://doi.org/10.1016/j.jss.2013.12.007.PubMedView ArticleGoogle Scholar
Liu W, Dong XS, Sun YQ, Liu Z. A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med. 2014;7(4):919–26.PubMed CentralPubMedGoogle Scholar
Homma K, Yoshida T, Yamashita M, Hayashida K, Hayashi M, Hori S. Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol. 2015. doi:https://doi.org/10.1159/000369068.
Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009;64(4):753–61. doi:https://doi.org/10.1007/s00280-008-0924-2.PubMedView ArticleGoogle Scholar
Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010;83(990):509–14. doi:https://doi.org/10.1259/bjr/25604811.PubMed CentralPubMedView ArticleGoogle Scholar
Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K. Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Jpn J Radiol. 2011;29(7):503–12. doi:https://doi.org/10.1007/s11604-011-0588-4.PubMedView ArticleGoogle Scholar
Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K. Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci. 2011;10(3):169–76.PubMedView ArticleGoogle Scholar
Katakura M, Hashimoto M, Tanabe Y, Shido O. Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Med Gas Res. 2012;2(1):18. doi:https://doi.org/10.1186/2045-9912-2-18.PubMed CentralPubMedView ArticleGoogle Scholar
Peng Z, Chen W, Wang L, Ye Z, Gao S, Sun X, et al. Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. Int J Clin Exp Pathol. 2015;8(3):2680–9.PubMed CentralPubMedGoogle Scholar
Matsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013;81(2):226–30. doi:https://doi.org/10.1016/j.urology.2012.10.026.PubMedView ArticleGoogle Scholar
Lee JW, Kim JI, Lee YA, Lee DH, Song CS, Cho YJ, et al. Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. J Pediatr Surg. 2012;47(4):736–42. doi:https://doi.org/10.1016/j.jpedsurg.2011.09.035.PubMedView ArticleGoogle Scholar
Jiang D, Wu D, Zhang Y, Xu B, Sun X, Li Z. Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol. 2012;187(6):2249–53. doi:https://doi.org/10.1016/j.juro.2012.01.029.PubMedView ArticleGoogle Scholar
Fan M, Xu X, He X, Chen L, Qian L, Liu J, et al. Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. J Urol. 2013;190(1):350–6. doi:https://doi.org/10.1016/j.juro.2012.12.001.PubMedView ArticleGoogle Scholar
Li S, Lu D, Zhang Y, Zhang Y. Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet. 2014;31(1):109–14. doi:https://doi.org/10.1007/s10815-013-0102-2.PubMed CentralPubMedView ArticleGoogle Scholar
Chen S, Jiang W. Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. Int J Clin Exp Med. 2015;8(4):5565–70.PubMed CentralPubMedGoogle Scholar
Zhao L, Wang YB, Qin SR, Ma XM, Sun XJ, Wang ML, et al. Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B. 2013;14(5):382–91. doi:https://doi.org/10.1631/jzus.B1200317.PubMed CentralPubMedView ArticleGoogle Scholar
Yoon KS, Huang XZ, Yoon YS, Kim SK, Song SB, Chang BS, et al. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biol Pharm Bull. 2011;34(11):1671–7.PubMedView ArticleGoogle Scholar
Guo Z, Zhou B, Li W, Sun X, Luo D. Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. J Biomed Res. 2012;26(5):365–71. doi:https://doi.org/10.7555/JBR.26.20110037.PubMed CentralPubMedView ArticleGoogle Scholar
Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 2012;106:24–33. doi:https://doi.org/10.1016/j.jphotobiol.2011.09.006.PubMedView ArticleGoogle Scholar
Ignacio RM, Yoon Y-S, Sajo MEJ, Kim C-S, Kim D-H, Kim S-K, et al. The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Mol Cell Toxicol. 2013;9(1):15–21. doi:https://doi.org/10.1007/s13273-013-0003-6.View ArticleGoogle Scholar
Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Nakazawa J, et al. Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Med Gas Res. 2012;2(1):14. doi:https://doi.org/10.1186/2045-9912-2-14.PubMed CentralPubMedView ArticleGoogle Scholar
Ignacio RM, Kwak HS, Yun YU, Sajo ME, Yoon YS, Kim CS, et al. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med. 2013;2013:538673. doi:https://doi.org/10.1155/2013/538673.PubMed CentralPubMedView ArticleGoogle Scholar
Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS, Lee KJ. Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull. 2014;37(9):1480–5.PubMedView ArticleGoogle Scholar
Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, Naritomi Y, et al. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep. 2015;12(2):2757–64. doi:https://doi.org/10.3892/mmr.2015.3707.PubMedGoogle Scholar
Li Q, Kato S, Matsuoka D, Tanaka H, Miwa N. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res. 2013;3(1):20. doi:https://doi.org/10.1186/2045-9912-3-20.PubMed CentralPubMedView ArticleGoogle Scholar
Yu W, Chiu Y, Lee C, Yoshioka T, Yu H. Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. J Asian Earth Sci. 2013;77:342–8. doi:https://doi.org/10.1016/j.jseaes.2013.07.007.View ArticleGoogle Scholar
Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27. doi:https://doi.org/10.1186/2045-9912-2-27.PubMed CentralPubMedView ArticleGoogle Scholar
Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, et al. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2014;21(2):468–73. doi:https://doi.org/10.1016/j.intimp.2014.06.001.PubMedView ArticleGoogle Scholar
Cai WW, Zhang MH, Yu YS, Cai JH. Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem. 2013;373(1–2):1–9. doi:https://doi.org/10.1007/s11010-012-1450-4.PubMedView ArticleGoogle Scholar
Hanaoka T, Kamimura N, Yokota T, Takai S, Ohta S. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Med Gas Res. 2011;1(1):18. doi:https://doi.org/10.1186/2045-9912-1-18.PubMed CentralPubMedView ArticleGoogle Scholar
Huang T, Wang W, Tu C, Yang Z, Bramwell D, Sun X. Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res. 2015;194(2):471–80. doi:https://doi.org/10.1016/j.jss.2014.12.016.PubMedView ArticleGoogle Scholar
Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res. 2011;1(1):24. doi:https://doi.org/10.1186/2045-9912-1-24.PubMed CentralPubMedView ArticleGoogle Scholar
Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012;2(1):12. doi:https://doi.org/10.1186/2045-9912-2-12.PubMed CentralPubMedView ArticleGoogle Scholar
Ostojic SM, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med. 2014;126(5):187–95. doi:https://doi.org/10.3810/pgm.2014.09.2813.PubMedView ArticleGoogle Scholar
Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun. 2008;377(4):1195–8. doi:https://doi.org/10.1016/j.bbrc.2008.10.156.PubMedView ArticleGoogle Scholar
Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Irie K, Azuma T, et al. Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol. 2012;57(12):1615–22. doi:https://doi.org/10.1016/j.archoralbio.2012.04.013.PubMedView ArticleGoogle Scholar
Jiang H, Yu P, Qian DH, Qin ZX, Sun XJ, Yu J, et al. Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med. 2013;31(6):1381–7. doi:https://doi.org/10.3892/ijmm.2013.1334.PubMedGoogle Scholar
Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, et al. Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res. 2012;94(1):144–53. doi:https://doi.org/10.1093/cvr/cvs024.PubMed CentralPubMedView ArticleGoogle Scholar
Sakai T, Sato B, Hara K, Hara Y, Naritomi Y, Koyanagi S, et al. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag. 2014;10:591–7. doi:https://doi.org/10.2147/VHRM.S68844.PubMed CentralPubMedGoogle Scholar
Zhao S, Mei K, Qian L, Yang Y, Liu W, Huang Y, et al. Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol Biochem. 2013;32(3):549–60. doi:https://doi.org/10.1159/000354459.PubMedView ArticleGoogle Scholar
Kawasaki H, Guan J, Tamama K. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochem Biophys Res Commun. 2010;397(3):608–13. doi:https://doi.org/10.1016/j.bbrc.2010.06.009.PubMedView ArticleGoogle Scholar
Tanikawa R, Takahashi I, Okubo N, Ono M, Okumura T, Ishibashi G, et al. Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population. Hirosaki Medical Journal. 2015;65:138–46.Google Scholar
Takeuchi S, Wada K, Nagatani K, Osada H, Otani N, Nawashiro H. Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Intern Med. 2012;51(11):1309–13.PubMedView ArticleGoogle Scholar
Kato S, Hokama R, Okayasu H, Saitoh Y, Iwai K, Miwa N. Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol. 2012;12(5):4019–27.PubMedView ArticleGoogle Scholar
Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28(3):137–43. doi:https://doi.org/10.1016/j.nutres.2008.01.008.PubMedView ArticleGoogle Scholar
Kamimura N, Nishimaki K, Ohsawa I, Ohta S. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity. 2011;19(7):1396–403. doi:https://doi.org/10.1038/oby.2011.6.PubMedView ArticleGoogle Scholar
Li Y, Hamasaki T, Nakamichi N, Kashiwagi T, Komatsu T, Ye J, et al. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology. 2011;63(2):119–31. doi:https://doi.org/10.1007/s10616-010-9317-6.PubMed CentralPubMedView ArticleGoogle Scholar
Yu P, Wang Z, Sun X, Chen X, Zeng S, Chen L, et al. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochem Biophys Res Commun. 2011;409(2):350–5. doi:https://doi.org/10.1016/j.bbrc.2011.05.024.PubMedView ArticleGoogle Scholar
Wang QJ, Zha XJ, Kang ZM, Xu MJ, Huang Q, Zou DJ. Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl). 2012;125(9):1633–7. doi:https://doi.org/10.3760/cma.j.issn.0366-6999.2012.09.020.Google Scholar
Amitani H, Asakawa A, Cheng K, Amitani M, Kaimoto K, Nakano M, et al. Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. PLoS One. 2013;8(1):e53913. doi:https://doi.org/10.1371/journal.pone.0053913.PubMed CentralPubMedView ArticleGoogle Scholar
Zong C, Song G, Yao S, Li L, Yu Y, Feng L, et al. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism. 2012;61(6):794–800. doi:https://doi.org/10.1016/j.metabol.2011.10.014.PubMedView ArticleGoogle Scholar
Song G, Li M, Sang H, Zhang L, Li X, Yao S, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013;54(7):1884–93. doi:https://doi.org/10.1194/jlr.M036640.PubMed CentralPubMedView ArticleGoogle Scholar
Song G, Lin Q, Zhao H, Liu M, Ye F, Sun Y, et al. Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized and placebo-controlled trial. J Clin Endocrinol Metab. 2015;100:2724–33. doi:https://doi.org/10.1210/jc.2015-1321.PubMedView ArticleGoogle Scholar
Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46(2):140–9. doi:https://doi.org/10.3164/jcbn.09-100.PubMed CentralPubMedView ArticleGoogle Scholar
Hashimoto M, Katakura M, Nabika T, Tanabe Y, Hossain S, Tsuchikura S, et al. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Med Gas Res. 2011;1(1):26. doi:https://doi.org/10.1186/2045-9912-1-26.PubMed CentralPubMedView ArticleGoogle Scholar
Nishimura N, Tanabe H, Adachi M, Yamamoto T, Fukushima M. Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats. J Nutr. 2013;143(12):1943–9. doi:https://doi.org/10.3945/jn.113.183004.PubMedView ArticleGoogle Scholar
Nakai Y, Sato B, Ushiama S, Okada S, Abe K, Arai S. Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Biosci Biotechnol Biochem. 2011;75(4):774–6. doi:https://doi.org/10.1271/bbb.100819.PubMedView ArticleGoogle Scholar
Ostojic SM. Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clin Proc. 2012;87(5):501–2. doi:https://doi.org/10.1016/j.mayocp.2012.02.008.PubMed CentralPubMedView ArticleGoogle Scholar
Ostojic SM, Stojanovic MD. Hydrogen-rich water affected blood alkalinity in physically active men. Res Sports Med. 2014;22(1):49–60. doi:https://doi.org/10.1080/15438627.2013.852092.PubMedView ArticleGoogle Scholar
Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, et al. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock. 2010;34(1):90–7. doi:https://doi.org/10.1097/SHK.0b013e3181cdc4ae.PubMedView ArticleGoogle Scholar
Zhou J, Chen Y, Huang GQ, Li J, Wu GM, Liu L, et al. Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. J Surg Res. 2012;178(1):390–400. doi:https://doi.org/10.1016/j.jss.2012.01.041.PubMedView ArticleGoogle Scholar
Xie K, Fu W, Xing W, Li A, Chen H, Han H, et al. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock. 2012;38(6):656–63. doi:https://doi.org/10.1097/SHK.0b013e3182758646.PubMedGoogle Scholar
Li GM, Ji MH, Sun XJ, Zeng QT, Tian M, Fan YX, et al. Effects of hydrogen-rich saline treatment on polymicrobial sepsis. J Surg Res. 2013;181(2):279–86. doi:https://doi.org/10.1016/j.jss.2012.06.058.PubMedView ArticleGoogle Scholar
Liu W, Shan LP, Dong XS, Liu XW, Ma T, Liu Z. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol. 2013;19(4):492–502. doi:https://doi.org/10.3748/wjg.v19.i4.492.PubMed CentralPubMedView ArticleGoogle Scholar
Yu Y, Wang WN, Han HZ, Xie KL, Wang GL, Yu YH. Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin. Genet Mol Res. 2015;14(2):6202–12. doi:https://doi.org/10.4238/2015.June.9.6.PubMedView ArticleGoogle Scholar
Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, et al. Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model. Shock. 2010;34(5):495–501. doi:https://doi.org/10.1097/SHK.0b013e3181def9aa.PubMedView ArticleGoogle Scholar
Xu Z, Zhou J, Cai J, Zhu Z, Sun X, Jiang C. Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond). 2012;9:2. doi:https://doi.org/10.1186/1476-9255-9-2.View ArticleGoogle Scholar
Fujii Y, Shirai M, Inamori S, Shimouchi A, Sonobe T, Tsuchimochi H, et al. Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artif Organs. 2013;37(2):136–41. doi:https://doi.org/10.1111/j.1525-1594.2012.01535.x.PubMedView ArticleGoogle Scholar
Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 2008;441(2):167–72. doi:https://doi.org/10.1016/j.neulet.2008.05.077.PubMedView ArticleGoogle Scholar
Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009;1256:129–37. doi:https://doi.org/10.1016/j.brainres.2008.11.048.PubMedView ArticleGoogle Scholar
Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, et al. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatr Res. 2010;68(5):387–92. doi:https://doi.org/10.1203/PDR.0b013e3181f2e81c.PubMedGoogle Scholar
Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, et al. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med. 2014;69:324–30. doi:https://doi.org/10.1016/j.freeradbiomed.2014.01.037.PubMedView ArticleGoogle Scholar
Yang X, Guo L, Sun X, Chen X, Tong X. Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta. 2011;32(9):681–6. doi:https://doi.org/10.1016/j.placenta.2011.06.020.PubMedView ArticleGoogle Scholar
Guan Z, Li HF, Guo LL, Yang X. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet. 2015;292(2):337–42. doi:https://doi.org/10.1007/s00404-015-3647-8.PubMedView ArticleGoogle Scholar
Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N. Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res. 2008;17(6):247–55.PubMedView ArticleGoogle Scholar
Zhao L, Zhou C, Zhang J, Gao F, Li B, Chuai Y, et al. Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. Int J Biol Sci. 2011;7(3):297–300.PubMed CentralPubMedView ArticleGoogle Scholar
Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, et al. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biol Pharm Bull. 2008;31(1):19–26.PubMedView ArticleGoogle Scholar
Runtuwene J, Amitani H, Amitani M, Asakawa A, Cheng KC, Inui A. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ. 2015;3:e859. doi:https://doi.org/10.7717/peerj.859.PubMed CentralPubMedView ArticleGoogle Scholar
Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, et al. The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res. 2010;51(6):741–7. doi:https://doi.org/10.1269/jrr.10093.PubMedView ArticleGoogle Scholar
Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2011;301(4):L415–26. doi:https://doi.org/10.1152/ajplung.00008.2011.PubMedView ArticleGoogle Scholar
Jiang Z, Xu B, Yang M, Li Z, Zhang Y, Jiang D. Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 2013;112(3):186–91. doi:https://doi.org/10.1111/bcpt.12016.PubMedView ArticleGoogle Scholar
Mei K, Zhao S, Qian L, Li B, Ni J, Cai J. Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat. 2014;25(2):182–8. doi:https://doi.org/10.3109/09546634.2012.762639.PubMedView ArticleGoogle Scholar
Watanabe S, Fujita M, Ishihara M, Tachibana S, Yamamoto Y, Kaji T, et al. Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats. J Radiat Res. 2014;55(6):1107–13. doi:https://doi.org/10.1093/jrr/rru067.PubMed CentralPubMedView ArticleGoogle Scholar
Qian L, Cao F, Cui J, Huang Y, Zhou X, Liu S, et al. Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res. 2010;44(3):275–82. doi:https://doi.org/10.3109/10715760903468758.PubMedView ArticleGoogle Scholar
Qian L, Li B, Cao F, Huang Y, Liu S, Cai J, et al. Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nucl Technol Radiat Prot. 2010;25(1):23–9. doi:https://doi.org/10.2298/ntrp1001023q.View ArticleGoogle Scholar
Chuai Y, Gao F, Li B, Zhao L, Qian L, Cao F, et al. Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochem J. 2012;442(1):49–56. doi:https://doi.org/10.1042/BJ20111786.PubMedView ArticleGoogle Scholar
Yang Y, Li B, Liu C, Chuai Y, Lei J, Gao F, et al. Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit. 2012;18(4):BR144–8.PubMed CentralPubMedView ArticleGoogle Scholar
Chuai Y, Shen J, Qian L, Wang Y, Huang Y, Gao F, et al. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit. 2012;18(3):BR89–94.PubMed CentralPubMedView ArticleGoogle Scholar
Yang Y, Gao F, Zhang H, Hunag Y, Zhang P, Liu C, et al. Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation. Int J Radiat Biol. 2013;89(12):1003–8. doi:https://doi.org/10.3109/09553002.2013.817704.PubMedView ArticleGoogle Scholar
Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, et al. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011;1(1):11. doi:https://doi.org/10.1186/2045-9912-1-11.PubMed CentralPubMedView ArticleGoogle Scholar
Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, et al. Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med. 2014;18(5):938–46. doi:https://doi.org/10.1111/jcmm.12245.PubMed CentralPubMedView ArticleGoogle Scholar
Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, et al. Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Crit Care Med. 2011;39(4):765–9. doi:https://doi.org/10.1097/CCM.0b013e318206bf44.PubMedView ArticleGoogle Scholar
Wang W, Li Y, Ren J, Xia F, Li J, Zhang Z. Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurol Res. 2012;34(10):1007–15. doi:https://doi.org/10.1179/1743132812Y.0000000106.PubMedView ArticleGoogle Scholar
Shen MH, Cai JM, Sun Q, Zhang DW, Huo ZL, He J, et al. Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther. 2013;19(5):361–3. doi:https://doi.org/10.1111/cns.12094.PubMedView ArticleGoogle Scholar
Wang W, Tian L, Li Y, Wang X, Xia F, Li L, et al. Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. J Emerg Med. 2013;44(1):107–15. doi:https://doi.org/10.1016/j.jemermed.2012.01.065.PubMedView ArticleGoogle Scholar
Yonamine R, Satoh Y, Kodama M, Araki Y, Kazama T. Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology. 2013;118(1):105–13. doi:https://doi.org/10.1097/ALN.0b013e318275146d.PubMedView ArticleGoogle Scholar
Takaenoki Y, Satoh Y, Araki Y, Kodama M, Yonamine R, Yufune S, et al. Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood. Anesthesiology. 2014;120(2):403–15. doi:https://doi.org/10.1097/ALN.0000435846.28299.e7.PubMedView ArticleGoogle Scholar
Wu S, Zhu L, Yang J, Fan Z, Dong Y, Luan R, et al. Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie. 2014;69(8):633–6.PubMedGoogle Scholar
Yoon YS, Kim DH, Kim SK, Song SB, Uh Y, Jin D, et al. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. Food Chem Toxicol. 2011;49(8):1814–9. doi:https://doi.org/10.1016/j.fct.2011.04.033.PubMedView ArticleGoogle Scholar
Wang T, Zhao L, Liu M, Xie F, Ma X, Zhao P, et al. Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol. 2014;280(1):169–76. doi:https://doi.org/10.1016/j.taap.2014.06.011.PubMedView ArticleGoogle Scholar
Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM, Sugimoto R, et al. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010;29(5):544–53. doi:https://doi.org/10.1016/j.healun.2009.10.011.PubMedView ArticleGoogle Scholar
Tan M, Sun X, Guo L, Su C, Sun X, Xu Z. Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. Int J Cardiol. 2013;167(2):383–90. doi:https://doi.org/10.1016/j.ijcard.2011.12.109.PubMedView ArticleGoogle Scholar
Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, Masutani K, et al. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int. 2012;25(12):1213–22. doi:https://doi.org/10.1111/j.1432-2277.2012.01542.x.PubMedView ArticleGoogle Scholar
Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation. 2010;90(12):1344–51. doi:https://doi.org/10.1097/TP.0b013e3181fe1357.PubMedView ArticleGoogle Scholar
Zhou H, Fu Z, Wei Y, Liu J, Cui X, Yang W, et al. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant. 2013;32(2):251–8. doi:https://doi.org/10.1016/j.healun.2012.11.007.PubMedView ArticleGoogle Scholar
Noda K, Shigemura N, Tanaka Y, Bhama J, D’Cunha J, Kobayashi H, et al. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. Transplantation. 2014;98(5):499–506. doi:https://doi.org/10.1097/TP.0000000000000254.PubMedView ArticleGoogle Scholar
Haam S, Lee S, Paik HC, Park MS, Song JH, Lim BJ, et al. The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger. Eur J Cardiothorac Surg. 2015;48:542–7. doi:https://doi.org/10.1093/ejcts/ezv057.PubMedView ArticleGoogle Scholar
Liu R, Fang X, Meng C, Xing J, Liu J, Yang W, et al. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood). 2015;240:1214–22. doi:https://doi.org/10.1177/1535370214563895.View ArticleGoogle Scholar
Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008;8(10):2015–24. doi:https://doi.org/10.1111/j.1600-6143.2008.02359.x.PubMedView ArticleGoogle Scholar
Shigeta T, Sakamoto S, Li XK, Cai S, Liu C, Kurokawa R, et al. Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation. 2015;99(3):500–7. doi:https://doi.org/10.1097/TP.0000000000000510.PubMedView ArticleGoogle Scholar
Luo ZL, Cheng L, Ren JD, Fang C, Xiang K, Xu HT, et al. Hydrogen-rich saline protects against ischemia/reperfusion injury in grafts after pancreas transplantations by reducing oxidative stress in rats. Mediators Inflamm. 2015;2015:281985. doi:https://doi.org/10.1155/2015/281985.PubMed CentralPubMedGoogle Scholar
Yamada T, Uchida K, Onuma K, Kuzuno J, Ujihira M, Inoue G, et al. Hydrogen supplementation of preservation solution improves viability of osteochondral grafts. ScientificWorldJournal. 2014;2014:109876. doi:https://doi.org/10.1155/2014/109876.PubMed CentralPubMedView ArticleGoogle Scholar
Qian L, Mei K, Shen J, Cai J. Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). Transplantation. 2013;95(5):658–62. doi:https://doi.org/10.1097/TP.0b013e31827e6b23.PubMedView ArticleGoogle Scholar
Yuan L, Chen X, Qian L, Shen J, Cai J. Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation. Med Sci Monit. 2015;21:749–54. doi:https://doi.org/10.12659/MSM.891338.PubMed CentralPubMedView ArticleGoogle Scholar
Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, et al. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation. 2014;130(24):2173–80. doi:https://doi.org/10.1161/CIRCULATIONAHA.114.011848.PubMedView ArticleGoogle Scholar
Huo TT, Zeng Y, Liu XN, Sun L, Han HZ, Chen HG, et al. Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. Anesth Analg. 2014;119(2):368–80. doi:https://doi.org/10.1213/ANE.0000000000000303.PubMedView ArticleGoogle Scholar
Du Z, Jia H, Liu J, Zhao X, Wang Y, Sun X. Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Exp Ther Med. 2014;7(5):1253–8. doi:https://doi.org/10.3892/etm.2014.1572.PubMed CentralPubMedGoogle Scholar
Du Z, Jia H, Liu J, Zhao X, Xu W. Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res. 2015;193(1):377–82. doi:https://doi.org/10.1016/j.jss.2014.06.051.PubMedView ArticleGoogle Scholar
Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, et al. Biological effects of electrolyzed water in hemodialysis. Nephron Clin Pract. 2009;112(1):c9–15. doi:https://doi.org/10.1159/000210569.PubMedView ArticleGoogle Scholar
Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010;25(9):3026–33. doi:https://doi.org/10.1093/ndt/gfq196.PubMedView ArticleGoogle Scholar
Terawaki H, Zhu WJ, Matsuyama Y, Terada T, Takahashi Y, Sakurai K, et al. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int. 2014;18(2):459–66. doi:https://doi.org/10.1111/hdi.12112.PubMedView ArticleGoogle Scholar
Tange Y, Takesawa S, Yoshitake S. Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon. 2015;7(2):e26847. doi:https://doi.org/10.5812/numonthly.26847.PubMed CentralPubMedGoogle Scholar
Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, et al. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res. 2013;3(1):14. doi:https://doi.org/10.1186/2045-9912-3-14.PubMed CentralPubMedView ArticleGoogle Scholar
Terawaki H, Nakano H, Zhu WJ, Nakayama M. Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int. 2015;35(1):107–12. doi:https://doi.org/10.3747/pdi.2013.00255.PubMedPubMed CentralView ArticleGoogle Scholar
Yan H, Tian H, Kinjo T, Hamasaki T, Tomimatsu K, Nakamichi N, et al. Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water. Biosci Biotechnol Biochem. 2010;74(10):2011–5. doi:https://doi.org/10.1271/bbb.100250.PubMedView ArticleGoogle Scholar
Nakata K, Yamashita N, Noda Y, Ohsawa I. Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res. 2015;5(1):2. doi:https://doi.org/10.1186/s13618-014-0023-x.PubMed CentralPubMedView ArticleGoogle Scholar
Ni XX, Cai ZY, Fan DF, Liu Y, Zhang RJ, Liu SL, et al. Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviat Space Environ Med. 2011;82(6):604–9. doi:https://doi.org/10.3357/asem.2964.2011.PubMedView ArticleGoogle Scholar
Saitoh Y, Harata Y, Mizuhashi F, Nakajima M, Miwa N. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicol Ind Health. 2010;26(4):203–16. doi:https://doi.org/10.1177/0748233710362989.PubMedView ArticleGoogle Scholar
Chen M, Cui W, Zhu K, Xie Y, Zhang C, Shen W. Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production. J Hazard Mater. 2014;267:40–7. doi:https://doi.org/10.1016/j.jhazmat.2013.12.029.PubMedView ArticleGoogle Scholar
Xie Y, Mao Y, Lai D, Zhang W, Shen W. H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion. PLoS One. 2012;7(11):e49800. doi:https://doi.org/10.1371/journal.pone.0049800.PubMed CentralPubMedView ArticleGoogle Scholar
Xu S, Zhu S, Jiang Y, Wang N, Wang R, Shen W, et al. Hydrogen-rich water alleviates salt stress in rice during seed germination. Plant Soil. 2013;370(1–2):47–57. doi:https://doi.org/10.1007/s11104-013-1614-3.View ArticleGoogle Scholar
Hu H, Li P, Wang Y, Gu R. Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit. Food Chem. 2014;156:100–9. doi:https://doi.org/10.1016/j.foodchem.2014.01.067.PubMedView ArticleGoogle Scholar
Xie Y, Mao Y, Zhang W, Lai D, Wang Q, Shen W. Reactive Oxygen Species-Dependent Nitric Oxide Production Contributes to Hydrogen-Promoted Stomatal Closure in Arabidopsis. Plant Physiol. 2014;165(2):759–73. doi:https://doi.org/10.1104/pp.%20114.237925.PubMed CentralPubMedView ArticleGoogle Scholar
Su N, Wu Q, Liu Y, Cai J, Shen W, Xia K, et al. Hydrogen-rich water reestablishes ROS homeostasis but exerts differential effects on anthocyanin synthesis in two varieties of radish sprouts under UV-A irradiation. J Agric Food Chem. 2014;62(27):6454–62. doi:https://doi.org/10.1021/jf5019593.PubMedView ArticleGoogle Scholar
Zhang X, Zhao X, Wang Z, Shen W, Xu X. Protective effects of hydrogen-rich water on the photosynthetic apparatus of maize seedlings (Zea mays L.) as a result of an increase in antioxidant enzyme activities under high light stress. Plant Growth Regul. 2015;77:43–56.View ArticleGoogle Scholar
Zeng J, Zhang M, Sun X. Molecular hydrogen is involved in phytohormone signaling and stress responses in plants. PLoS One. 2013;8(8):e71038. doi:https://doi.org/10.1371/journal.pone.0071038.PubMed CentralPubMedView ArticleGoogle Scholar
Jin Q, Zhu K, Cui W, Xie Y, Han B, Shen W. Hydrogen gas acts as a novel bioactive molecule in enhancing plant tolerance to paraquat-induced oxidative stress via the modulation of heme oxygenase-1 signalling system. Plant Cell Environ. 2013;36(5):956–69. doi:https://doi.org/10.1111/pce.12029.PubMedView ArticleGoogle Scholar
Cui W, Gao C, Fang P, Lin G, Shen W. Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water. J Hazard Mater. 2013;260:715–24. doi:https://doi.org/10.1016/j.jhazmat.2013.06.032.PubMedView ArticleGoogle Scholar
Wu Q, Su N, Cai J, Shen Z, Cui J. Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities. J Plant Physiol. 2015;175:174–82. doi:https://doi.org/10.1016/j.jplph.2014.09.017.PubMedView ArticleGoogle Scholar
Cui W, Fang P, Zhu K, Mao Y, Gao C, Xie Y, et al. Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings. Ecotoxicol Environ Saf. 2014;105:103–11. doi:https://doi.org/10.1016/j.ecoenv.2014.04.009.PubMedView ArticleGoogle Scholar
Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun. 2008;375(3):346–50. doi:https://doi.org/10.1016/j.bbrc.2008.08.020.PubMedView ArticleGoogle Scholar
Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, et al. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Med Gas Res. 2012;2(1):21. doi:https://doi.org/10.1186/2045-9912-2-21.PubMed CentralPubMedView ArticleGoogle Scholar
Seo T, Kurokawa R, Sato B. A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum. Med Gas Res. 2012;2:1. doi:https://doi.org/10.1186/2045-9912-2-1.PubMed CentralPubMedView ArticleGoogle Scholar
Shimouchi A, Nose K, Shirai M, Kondo T. Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water. Adv Exp Med Biol. 2012;737:245–50. doi:https://doi.org/10.1007/978-1-4614-1566-4_36.PubMedView ArticleGoogle Scholar
Shimouchi A, Nose K, Mizukami T, Che DC, Shirai M. Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas. Adv Exp Med Biol. 2013;789:315–21. doi:https://doi.org/10.1007/978-1-4614-7411-1_42.PubMedView ArticleGoogle Scholar
Liu C, Kurokawa R, Fujino M, Hirano S, Sato B, Li XK. Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. Sci Rep. 2014;4:5485. doi:https://doi.org/10.1038/srep05485.PubMed CentralPubMedGoogle Scholar
Penders J, Kissner R, Koppenol WH. ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite. Free Radic Biol Med. 2014;75:191–4. doi:https://doi.org/10.1016/j.freeradbiomed.2014.07.025.PubMedView ArticleGoogle Scholar
Kato S, Matsuoka D, Miwa N. Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2′-bipyridyl methods. Mater Sci Eng C Mater Biol Appl. 2015;53:7–10. doi:https://doi.org/10.1016/j.msec.2015.03.064.PubMedView ArticleGoogle Scholar

acqua ionizzata alcalina con idrogeno molecolare e le migliori purificatori filtri ionizzatori d'acqua

Archivi tag: stomac și hidrogen molecular

idrogeno molecolare biatomico H _2- Prodotti per l’acqua idrogenata

Le migliori ionizzatori e filtri d'acqua, prezzi decenti

Benefici / effetti dell’idrogeno molecolare (acqua) in modelli patologici, malattie umane, patologie associate al trattamento e condizioni patofisiologiche delle piante

idrogeno molecolare biatomico H 2- Prodotti per l’acqua idrogenata

(Română) Spune si altora-click aici

Le migliori ionizzatori e filtri d'acqua, prezzi decenti

idrogeno molecolare biatomico H _2- Prodotti per l’acqua idrogenata